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강현본(Hyun Bon Kang),최윤식(Yun Sik Choi),박지아(Jia Bak),장영아(Young Ah Jang) 한국문화융합학회 2020 문화와 융합 Vol.42 No.12
화장품의 합성 화학물질들로 인한 부작용 때문에 친환경적이고 적은 독성을 가지는 천연물들에 대한 연구가 증가하고 있다. 피부 미백 또는 항주름 효과를 가지는 화장품 소재에 관한 연구들이 주를 이루었고 최근에는 피부장벽을 보호하는 천연물에 관한 연구가 등장하기 시작했다. 피부장벽의 붕괴는 건피증 뿐만 아니라 염증을 유발하며 이는 아토피와 같은 피부질환을 야기하기도 한다. 금전초는 항염증과 항산화 효과가 있어 이러한 피부질환으로부터 보호하는 효과가 있을 것으로 기대한다. 따라서 본 연구에서는 금전초가 피부장벽을 보호하는 효과에 대해서 평가하였다. 먼저 우리는 금전초 에탄올 추출물의 항산화 효과를 확인하였고 ascorbic acid와 유사한 항산화 효과를 보였다. 또한 금전초는 인간 각질형성세포에서 LDH release를 농도 의존적으로 감소시켰다. 더욱이, 에탄올 추출물은 인간 각질형성세포에서 filaggrin과 HAS2의 발현을 증가시켰다. 종합적으로, 이러한 결과들은 금전초 에탄올 추출물이 피부장벽 보호를 위한 화장품 소재로서 잠재력을 가지고 있음을 시사한다. Because of the adverse effects of synthetic chemical ingredients in various commercial products, natural compounds that are eco-friendly and have a lower toxicity have been recently used in the preparation of cosmetic products. In particular, skin-whitening or anti-wrinkle cosmetic products have been developed from eco-friendly raw materials, and recently, products based on natural compounds for skin barrier protection have been introduced. Disruption of the skin barrier causes xerosis as well as inflammation, resulting in skin disorders such as atopic dermatitis. Lysimachia christinae Hance is known to have anti-inflammatory and antioxidant activities, and is, thus, expected to have beneficial effects on skin disorders. This study was conducted to investigate the beneficial effect of Lysimachia christinae Hance on the protection of the skin barrier. It was observed that the ethanolic extract of Lysimachia christinae Hance exhibited an antioxidant effect, and its anti-oxidant potency was comparable to that of ascorbic acid. In addition, the ethanolic extract dose-dependently reduced the LDH release in cultured human keratinocytes. Furthermore, the ethanolic extract significantly increased the expression of filaggrin and HAS2 in cultured human keratinocytes. The experimental results of this study confirmed that the ethanolic extract of Lysimachia christinae Hance has considerable potential as a cosmetic ingredient for skin barrier protection.
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참당귀 추출물의 청색광 유도 망막색소상피세포(ARPE-19) 손상으로부터의 보호 효과
김현우(Hyeon Woo Kim),이윤제(Youn Je Lee),강현본(Hyun Bon Kang),김형회(Hyeong Hoi Kim),송일대(Il Dae Song),강재선(Jae Seon Kang) 대한약학회 2022 약학회지 Vol.66 No.3
Light pollution such as blue light exposure can damage the visual photoreceptors and lead to cell death and degenerative retinal diseases. Despite the increasing number of patients suffering from retinal disease, the therapeutic agents are still insufficient. Angelica gigas Nakai extract (AGNEX) containing a high proportion of decursin derivatives has effectively protected cells under oxidative stress or high-level blue light. However, it remains unclear whether it protects retinal cells effectively. Here, we investigated the cytoprotective effect of AGNEX on retinal cells damaged using reactive oxygen species (ROS), which decreased the viability of retinal cells by causing oxidative stress. The cell viability with 600 μM hydrogen peroxide treatment was less than 70% of the normal control group. However, the group treated with 40 μM of AGNEX showed recovery as the normal control group. ROS levels were decreased in the AGNEX treated at 10-20 μM compared with the 600 μM hydrogen peroxide group. The AGNEX treated group was reduced by 20% compared with the untreated control group. This study suggests that AGNEX could prevent damage to blue light-induced retinal cells by oxidative stress relief, suggesting its potential as a therapeutic agent similar to eye care functional foods and as medicine against retinal cell damage.
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