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- 저자 : 高光烈 (검색결과 4 건)
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脾臟均質液의 腹腔內注入이 X-線 全身照射 「마우스」의 皮下感染에 미치는 實驗的 硏究
高光烈,金箕洪 우석대학교 의과대학 1969 우석의대잡지 Vol.6 No.1
This study was carried out to evaluate the effects of intraperitoneal injection of spleen homogenate to X-irradiated mice with experimental subcutaneous infection. Four hundred and sixty mice were divided into the following four groups. 1. Control group with 100 mice. 2. X-irradiated group with 120 mice. 3. X-spleen treated group with 120 mice. 4. Cortisone treated group with 120 mice. The X-irradiated group recieved a single whole body irradiation of 400R and the X-spleen treated group was injected intraperitoneally with spleen homogenate of 2 young mice immediately after the same dose of X-irradiation. In the cortisone treated group 0.5 ㎎. was injected daily from days prior to inoculation of bacteria to the end of the experiment. In all groups 0.2 ㎖. (8.4×10^(7)-1×10^(8)) of E. coli (ATCC -0128 strain) suspension was injected into the subcutaneous tissue of the inner aspect of right thigh. At the 4th day after X-irradiation and initial cortisone administration 8 mice in each group were respectively sacrificed 1, 3, and 6 hours and 1, 2, 4, 6, 12 and 15 days after the inoculation of bacteria. Histological study of inoculated site and quantitative culture from blood, liver and spleen were done, and the results were as follows. 1. The number of extracellular non-phagocytized bacteria in the inoculated tissue : In the control group only small number of bacteria was found at the 1st hour. There were only few at the 1st day and practically no bacteria were seen thereafter. In contrast with the control group extremely numerous free bacteria were observed in the X-irradiated group at the 1st hour, few at the 4th day and none from the 6th day. The group with cortisone administration, numerous free bacteria were observed at the 1st hour as seen in the X-irradiated group, few in the 2nd day and none at the 9th day. 2. Inflammatory reaction: Inflammatory reaction was extremely severe at the 1st hour in the control group and this was continued until the 2nd day. Then, gradual decline of inflammatory reaction was continued. In the 15th day, little or no reaction was noted. The group with X-irradiation, practically no inflammatory reaction was observed at the 1st hour. At the 3rd hour reaction was weak. During the period of the 1st through 6th day inflammatory reaction was extremely severe. There were also seen areas of frank necrosis. There was mild infiammatory reaction still present in the 15th day. The cortisone treated group showed very weak reaction at the 1st hour became grdually stronger. Extremely severe reaction was noted only during the 1st and the 2nd day and then became very weak during the 6th to the 15th day. 3. Repair process evaluted by changes on various inflammatory cells: The repair process was markedly delayed in the X-irradiated group comparing to that of the control group. The X-spleen treated group was similar to the latter. In the cortisone treated group, inflammatory reaction was mild, suggesting considerable interruption of repair process. 4. The incidence of positive culture from the blood, liver and spleen: The incidence of positive culture was highest in the cortisone treated group, and decreased the X-irradiated, X-spleen treated and the control group in order. 5. The incidence of positive culture from the organs described above was highest at the 4th day. It would appear that the phagocytic cells of the regional lymph-nodes could not retain the phagocytized bacteria. In summary, this study clearly demonstrated that intraperitoneal injection of spleen homogenate protect definitely against the suppresion of primary natural defense mechanisms
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소비에트-폴란드 전쟁(1919~1921)과 볼셰비키의 세계 혁명관 변화
고광열 ( Kwangyirl Ko ) 한국서양사연구회(구 서울대학교 서양사연구회) 2016 서양사연구 Vol.0 No.54
This study is an inquiry into the impact of the Soviet-Polish War (1919-1921) on the course of revolutionary government during the Civil War period as a “formative experience.” Through the war, the Bolshevik leaders made a first attempt to export the socialist revolution to Poland and other countries on the principle of the international communism. At the Battle of Warsaw in August 1920, however, the Red Army was repulsed by Poland and thus the Bolsheviks’ euphoria of World Socialist Republic completely shattered. Many scholars have examined the war in various aspects, but are not enough to explain its influences on the Soviet leaders, which had finally caused changes of their perception and policy on the world revolution. This study sheds light on such a historical trace and argues that the Bolsheviks acted as Realpolitiker responding to fluctuating circumstances, rather than doctrinaires who persistently pursued the world revolution on the basis of their communist ideology. The Bolsheviks did not call into question those ideological “inconsistencies” which would take place in reality, simply if they could achieve the final goals. The fiasco of the Soviet-Polish War changed the Bolsheviks’ view of world revolution to a great extent. The Bolshevik leaders realized that the spread of socialist revolution to foreign countries should be understood not on the basis of the Marxist dogma, but as a possibility to be put into practice through desperate struggles with imperialist powers. Otherwise the regime would be threatened itself. It was through the defeat of the Soviet-Polish War that the Bolsheviks could recognize the necessity of peaceful coexistence with the capitalist states and the importance of rapid development into a strong state with modern industry and powerful armed forces. The ideal of world revolution was gradually encroached. (Seoul National University/turambar@snu.ac.kr)
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高一香,金箕洪,高光烈,金世煥,許沅,池貞姬 中央醫學社 1968 中央醫學 Vol.15 No.3
This is a case of 27 year old male who had had severe pruritis with marked exfoliative dermatitis of 2 year duration, followed by skin tumor and, finally, visceral involvement. The death was complicated by bilateral bronchopneumonia with asperosilosis. In addition to clinical observation, characteristic histologic finding of cellular multiplicity with atypical histiocytes, immature reticulum cells and Pautrier's microab- scesses in the skin & axillary node serially biopsied made confirmed diagnosis of mycosis fungoides. At autopsy, multiple involvement of lymph node, predominantly periaortic nodes, kidneys, adrenals, stomach and pancreas was disclosed. Histopathologic picture of these, without doubt, was that of reticulum cell sarcoma but neither picture of reticulum cell sarcoma nor mycosis fungoides were observed in the skin lesion at autopsy. As clearly demonstrated in this case, the striking similarities of viseral metastasis in mycosis fungoides to lesions of other lymphomas pose quetion of common etiology, pathogenesis and host response. However, it would appear that mycosis fungoides is distinguishable early in the disease from other malignant lymphoma solely on the basis of its characteristic clinical course and cutaneous histopathology.
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