피로수명예측을 위한 잔류강도 저하모델의 파라미터 결정법 제안(II)

김상태,장성수,Kim, Sang-Tae,Jang, Seong-Su 대한기계학회 2001 大韓機械學會論文集A Vol.25 No.9

A new method of parameter determination in the fatigue residual strength degradation model is proposed. The new method and minimization technique is compared experimentally to account for the effect of tension-compression fatigue loading of spheroidal graphite cast iron and graphite/epoxy laminate. It is shown that the correlation between the experimental results and the theoretical prediction on the fatigue life and residual strength distribution using the proposed method is very reasonable. Therefore, the proposed method is more adjustable in the determination of the parameter than minimization technique for the prediction of the fatigue characteristics.

의학상식-스트레스와 정신건강

김상태,Kim, Sang-Tae 한국건강관리협회 1985 건강소식 Vol.9 No.12

의학상식-아픔'만성통증'의 정체

김상태,Kim, Sang-Tae 한국건강관리협회 1985 건강소식 Vol.9 No.11

흰쥐 정소세포에서의 Cadmium 독성 작용과 Selenium 전처리의 영향

김상태,부문종,최임순 ( Sang Tae Kim,Moon Jong Boo,Rim Soon Choe ) 한국환경생물학회 1990 환경생물 : 환경생물학회지 Vol.8 No.1

To investigate the cadmium toxicity to testis and the effect of selenium pretreatment, male rats were subcutaneously injected with Cd and/or Se prior to Cd. In doing so, the respiration rates of mitochondria, the lysosomal activities of acid phosphatase and the cellular levels of GSH were measured. Also, the testicular ultrastructures were observed. Cd only-treated group showed that the respiration rates of mitochondria, the lysosomal activities of acid phosphatase and the level of GSH were reduced on the whole. In contrast to above group, Se-pretreated group appeared to be recovered: the respiration rate was restored more than that of control group and the enzyme activity was restored somewhat, however less than that of the control group. The level of GSH was recovered to the level of control group in Se-pretreated group. According to ultrastructural studies, Cd-treated group showed the swelling and destruction of mitochondria and the production of lipid droplets. In contrast, Se-pretreated group appeared not to be different from control group. So, all of these results would indicate that Se has a protective function against Cd toxicity in the rat testis.

Arbutin , Glycolic Acid , Kojic Acid 및 Pentadecenoic Acid가 in vitro 및 in vivo에서 UVB 조사에 의한 색소형성에 미치는 영향

김상태,서기석,채영수,엄상철 ( Sang Tae Kim,Kee Suck Suh,Young Soo Chae,Sang Cheul Eom ) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.6

멜라닌 색소의 합성을 조절하는 정확한 기전은 확실치 않지만 유전적 요인 이외에 자외선이나 호르몬과 같은 여러 물리적, 화학적, 생리적 요인이 멜라닌 합성을 조절한다고 알려져 있다. 자외선 조사 후 멜라닌 색소의 증가는 주로 색소세포내 tyrosinase의 활성화와 활동성 멜라닌 세포 수의 증가에 기인한다. 한편 멜라닌 세포의 증식을 감소시키고 멜라닌 합성을 억제하는 화합물로는 hydroquinone, monobenzylether of hydroquinone과 같은 catechol과 phenol화합물이 알려져 있으며 vitamin A 유도체인 trans-retinoic acid와 포화 dicarboxylic acid인 azelaic acid 등도 멜라닌 세포의 증식과 멜라닌 합성을 억제한다고 보고된 바 있다. 최근 arbution(hydroquinone-β-D-glucopyranoside), glycolic acid(GA), kojic acid(KA) 및 pentadecenoic acid(PDA) 등의 색소형성 억제 작용이 제시되고 있다. 이 중 hydroquinone 유도체인 arbutin은 세포 독성이 약하나 색소 형성을 상당히 억제하여 악성 흑생종 세포에서 멜라닌 색소 형성을 저하시킨다는 것이 알려졌으며, 탈피술(chemical peeling)에 사용되고 있는 GA는 eumelanin 합성을 억제하는 vitamin C와 화학적 구조가 유사하므로 GA가 멜라닌 세포와 피부 색조에 영향을 미칠수 있을 것으로 생각되나 확실히 규명된 바 없다. KA[5-hydroxy-2(hydroxymethyl)-4-pyrone]는 구리 이온과 결합하여 tyrosinase의 활성도를 억제하고 dihydroxy indol caboxylic acid로의 전환을 억제함으로서 색소 형성을 저하시킨다고 하며, PDA는 다중부포화 지방산으로 premelanosome의 구조를 변화시키고 멜라닌 색소 중합체의 형성과 peroxidase 활성도를 억제하는 등의 기전으로 색소 형성을 저하시킨다고 추정되고 있다. Arbutine, KA 및 PDA가 흑색종 세포 배양에서 멜라닌 색소 형성을 저하시킨다는 것이 알려졌으나 이들 약물이 배양된 정상 인체 멜라닌 세포에 미치는 영향과 in vivo에서의 멜라닌 세포 수와 형태학적 변화에 미치는 영향은 아직 확실치 않다. 이에 저자들은 배양된 정상 인체 멜라닌 세포와 B-16 흑색종 세포 및 C57EL 흑색 생쥐 피부에 이들 약물을 투여하거나 도포하여 배양된 멜라닌 세포와 B-16 흑색종 세포에서는 세포 수와 멜라닌 양을 측정하고 C57BL 흑색 생쥐에서는 DOPA 염색을 시행하여 멜라닌 세포의 수적, 형태학적 변화를 관찰함으로서 UVB를 조사하지 않은 상태에서의 색소형성 억제 효과를 알아 보고자 하였다. 그리고 배양된 멜라닌 세포와 B-16 흑색종 세포 C57BL 흑색 생쥐 피부 및 인체 피부에 각각 UVB를 조사한 후 이들 약물을 투여하여 UVB 조사에 의한 색소형성에 미치는 영향을 알아보기 위해 본 연구를 시행하였다. Background:Melanin pigmentation palys a major role in normal skin color. The rates of melanin synthesis by melanocytes appear to be regulated by ultraviolet-B UVB) rediation and chemicals, though the precise mechanisms modulating human epidermal pigmentation are unknown. Several chemicals including arbutin, kojic acid(KA), pentadecen?ic acid(PDA) and glycolic acid(GA) have been suggested as a melanogenesis inhibitory compounds because of their chemical or biological similarities with hydroquinone or their tyrosinase inhibitory effcet. Objective:The purpose of this study was to evaluate the inhibitory effect of arbutin, GA, KA and PDA on UV-induced melanogenesis in the in vitro and in vivo pigmentary system. Methods:Cultured normal melanocytes and B-16 melanoma cells, and C57BL mice and human volunteers were used for in vitro and in vivo studies respectively. They were administered to UVB irradiated or nonirradiated cultured normal human melanocytes, and B-16 melanoma cells. For the in vivo study, these chemicals were topically applied to C57BL mice and human ?olunteer skin after UVB irradiation. Numeric and morphologic changes and melanin content were measured in cultured normal human melanocytes and B-16 melanoma cells. In the C57BL mice, numeric and morphologic changes of split-DOPA stained melanocytes were assessed. In the human volunt?rs, gross pigementary changes wre evaluated. Results 1. The number and melanin content of cultured melanocytes initially decreased after UVB-irradiation, but the melanin content increased 5 days after irradiation. 2. Cell numbers of irradiated or nonirradiated cultured human melanocytes decreased in arbutin(10^-3M), KA(10^-3M, 10^-5M), PDA(10^-3M) groups. Those of the cultured B-16 mealnoma cells decreased only in the arbutin(10^-3M) group after UVB irradiation. 3. Melanin contents of cultured human melanocytes decreased in crbutin(10^-3M, 10^-5M), KA(10^-3M, 10^-5M) and PDA(10^-3M) groups. Those of cultured B-16 melanon a cells decreased in arbutin(10^-3M, 10^-5M) groups after UVB-irradiation or nonirradiation. 4. The number of split-DOPA(+) melanocytes decreased in the groups ?reated with KA 1% for 3,5 and 7 weeks, KA 0.1%, arbutin 3%, arbutin 5% for 5and 7 qwwks and PDA 5.0% for 7 weeks in the C57BL mice. 5. The number of split-DOPA(+) melanocytes decreased in the groups ?reated with KA 1.0%, PDA 5.0%, arbutin 3% and arbutin 5% for 5 and 7 weeks and KA 0.1% for 7 weeks in UVB irradiated C57BL mice. 6. Visible inhibition of UVB-induced hyperpigmentation was observed in arbutin applied sites in 4 of the 6 volunteers 3 weeks after the application. GA did not show an inhibitory effect on UVB-induced hyperpigmentation in all subjects. Conclusion:Arbutin, KA, PDA had a suppressive effect on ? of nonirradiated melanocytes and melanoma cells as well as UVB-induced hyperpigmentation. It is suggested that these drugs might be candidates as compounds that may control hyperpigmentary disorders.(Kor J Dermatol 1994;32(6):977~989)

7.8세기 동아시아 2탑식가람의 생성과 전개에 관한 연구

김상태,박언곤,Kim, Sang-Tae,Park, Eon-Kon 한국건축역사학회 2003 건축역사연구 Vol.12 No.4

This article works on the development process of the Buddhist Temple with two pagodas in the Eastern Asia. in 7-8th centuries. This study was motivated from the observation that why there are many the Buddhist Temple having two pagodas only around the late 7th century, roughly around 670 A.D.. This period corresponds to the Silla Dynasty(in Korean History) and Hakuho Period(in Japan History) among the Eastern Asia while the composition of the temple being changed as Buddhism spreads out from China. The results of this study are the followings. The appearance of the Buddhist Temple having two pagodas was resulted from the representation of the Ideology in Botabpum(dogma of pagoda security) of the Saddharmapundarika Sutra, that is to say, two Buddhas sit side by side and iconography of Esoteric Buddhism dogma supports the spirit for defending one's country. Buddhist Temple having two pagodas in China had separate tab-won(areas with pagodas outer temple building block). Buddhist Temple having two pagodas in Korea had begun with sacheunwangsa temple in Unified-Silla. But it had two pagodas with inner temple area instead of outer. This was different from the composition of China. It can be related to the layout of the temple haying two pagodas in East-Jin(in China History) and the sculpture of two pagodas in Ungang-stonecave(in China). Thus the layout of the Buddhist Temple having two pagodas in Silla had been originated from that of China, but was developed to the main temple layout on her own accord. As Japanese Temple having two pagodas had been influenced diplomatically, it had two pagodas inner area as like the layout in Shilla. But later under the influence of Tang it was modified to the layout having them in separate area. And this influence can be seen for example Tangchojaesa temple. For the more, We call see that the diplomatic trends according to the policies in East asia affected to Buddhism and then naturally also to the layout of the Buddhist Temple.

2000 산업기반기술개발사업 안내

김상태,Kim Sang-Tae 한국공학기술학회 2000 공학교육과 기술 Vol.7 No.2

직장인의 건강관리-직장인의 스트레스와 정신장애

김상태,Kim, Sang-Tae 한국건강관리협회 1987 건강소식 Vol.11 No.1

직장인의 스트레스와 나아가 이로 인한 정신장애의 극복책은 우선적으로 스트레스의 바른 해소책 개발과 인격적 취약성의 자각 및 인격 성숙을 위한 부단한 노력 이다.

정신병과 건강생활-정신건강이란 무엇인가

김상태,Kim, Sang-Tae 한국건강관리협회 1976 건강소식 Vol.4 No.9

사례기반추론을 이용한 개략비용 예측시스템 개발 - 토양경작법 정화비용사례를 중심으로 적용가능성 검토 -

김상태,심진아,김흥래,Kim, Sang-Tae,Shim, Jin-Ah,Kim, Heung-Rae 한국건설관리학회 2016 한국건설관리학회 논문집 Vol.17 No.1

가중사례기반추론 알고리즘을 이용하여 Excel VBA 기반의 개략비용 예측시스템을 개발하였다. 개발 시스템의 특징은 사례학습과 신규추정시 학습사례건수와 신규추정건수 만큼의 시트를 자동생성하며, 각각의 시트는 셀수식이 자동으로 입력되어 시스템의 활용성을 고려하였으며, 또한 영향인자를 최대 10개까지 선택이 가능하도록 하여 영향인자의 조합을 자유롭게 구성할 수 있도록 하였다. 개발한 비용예측시스템을 토양경작법 정화비용예측에 이용하여 토양정화 예측모델의 적용가능성을 검토하였다. 평균단가 예측모델은 물론 최적다중회귀 예측모델보다 개선된 결과를 확인하였다. 본 연구에서는 토양경작법을 대상으로 검토 하였으나 토양정화기술과 오염물질 종류 등 다양한 시나리오가 나타나는 토양정화사업분야에 사례기반추론을 이용한 비용예측모델은 향후 사례데이터 축적과 더불어 적용가능성이 커질 것으로 기대된다 This study proposes a approximate cost estimation system based on Excel with VBA using weighted CBR(Case Based Reasoning). One characteristic of this system is that it generates the sheet automatically as many as the number of similar case and new estimation when it performs a case learning and a new estimate and cell formula is automatically entered into each sheet. User can be free to compose a combination of attribute factors because they can select up to ten attribute factors. This paper presents an applicability of estimation model for estimating the soil remediation cost when it use a landfarming method. When compared to a estimation model by using average unit cost and optimum multiple regression, this model shows a better result. This study was aimed at landfarming method, but it is expected that a cost estimation model using CBR will be more likely to apply in soil remediation technologies which various remediation technologies and pollutant species exist.