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宋俊榮,鄭泰浩 계명대학교 醫科大學 皮膚科學 1993 仁耕 宋俊榮 敎授 華甲紀念 論文集 Vol.S No.-
Presently, four general procedures have introduced for separating different classes of plasma. lipoprotein, ultracentrifugation, electrophoresis, immunological precipitation, and polyanion precipitation with dextran sulfate. Very recently Sakurabayashi and . Kawai introduced the convenient technique separating for fractional quantitation of serum very .low density and low density lipoprotein by precipitation with heparin in calcium chloride solution. This report was planned to determine the fructuation of serum very low density and low density lipoprotein in lepromatous leprosy patients- 2O leprornato11s patients and 2O normal subjects were selected from the Aeluck Leprosy Hospital. Serum lipoprotein was analized by the method of Sakurabayashi and Kawai, serum transaminase by Sigma method and bilirubin was determined by Van Den Bergh’ s coloration technic with following results; Serum very low density lipoprotein . and low density lipoprotein of leprosy patients were 77.6 7.9mg% and 107.7 17.9mg%, these values were slightly lower than normal subject’s but not significant. Through cellulose acetate.electrophoresis of serum lipoprotein in normal and lepromatous patients no significant differences were noticed. The values of serum transaminase and bilirubin bf lepromatous patients also showed within normal limit
나환자의 혈정 Angiotensin converting enzyme치
송준영,박의수 계명대학교 醫科大學 皮膚科學 1993 仁耕 宋俊榮 敎授 華甲紀念 論文集 Vol.S No.-
Angiotensin-converting enzyme(ACE) is a dipeptidyl carboxypeptidase that is a membrane bound mainly on the luminal surface of pulmonary endothelial capillary cells. It functions to inactivate brady kinin, and also converts angiotensin 1 to angiotensin n. Activity of ACE was first identified in plasma by Skeggs and co-workers in 1956. In 1974 Lieberman discovered that elevated levels of serum ACE were associated with active sarcoidosis and that this assay would be used to assist a diagnosis of sarcoidosis. The association of sarcoidosis and enhanced ACE activity was su뼈equently supported by data from other investigators. Increased serum ACE levels have also been observed in patients with nongranulomatous diseases and granulomatous diseases including leprosy. The author studied the serum ACE levels in leprosy patients(fourty-three with tuberculoid type and eighty-nine with lepromatous type) and twenty nOrIl1al healthy controls by the spectrophotometric method described by Lieberman. Comparative studies of ACE levels in these two types of leprosy with nOrInal healthy controls and relationship among the duration of treatment, age, and sex were also conducted. The results were summarized as follows: Ages of the selected patients were between 30 to 77 years in tuberculoid leprosy (average 54. 1), 23 to 75 years in lepromatous leprosy(average 53.8) and 14 to 49years in the control group(average 28.4). The duration of treatment in tuberculoid leprosy was between 1 and 39 years and average was 20.7 years. Of lepromatous leprosy, duration of treatment was between 2 and 50 years and the average was25.4 years. The mean serum ACE level in normal healthy control group was 6. 39+2. 33 μ/ml,which was significantly lower than that of all leprosy patients, 9. 77+4. 31 μ/ml (p <0.001), and that of both the tuberculoid leprosy, 11. 33+5. 61 μIml(p <0.001) , and the lepromatous leprosy, 9.01±3.25μ/ml(p<O.Ol). There were no significant differences of serum ACE levels between the tuberculoid leprosy group and the lepromatous leprosy group and also no meaningful sex differences of serum ACE levels in leprosy and control group. There was no correlation between age and serum ACE levels in the tuberculoid leprosy, lepromatous leprosy and control groups. There was no relationship between the duration of dapsone treatment and serum ACE level in both the tuberculoid and lepromatous leprosy groups.