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- 저자 : 全浩秀(Chun, Ho-soo) (검색결과 6 건)
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전호수(Ho Su Chun),조광현(Kwang Hyun Cho),김철우(Chul Woo Kim) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.4
Background : Although actinic keratosis and Bowens disease ar considered as carcinoma in situ, most of them are biologically benign and dont progress to invasive squamous cell carcinoma. It is little known why they take the benign courses and which factors are involved in the tumorigenesis. Keratoacanthoma, self-regresi;ing benign tumor, may be sometimes or fused morphologically with well-differentiated squamous cell carcinoma. So it is necessary to find a useful marker to help us distinguish them. Objectives : We performed this study to gain a better understani ling of biologic behaviour and tumerigenesis of epidermal keiatinocytic neoplasms. Methods : We investigated the expression of p53 protein and priliferating cell nuclear antigen (PCNA) by an immunohistochemical method on the formalin-fixed, araffinembedded tissue specimens of epidermal keratinocytic neoplasms. Results : Fourteen out of 20 cases of squamous cell carcinoma(70.0%), 14 out of 22 cases of actinic keratosis(63.6%), and 13 out of 20 cases of Bowens disease(65.0%) showed p53 protein expression, but keratoacanthoma was negative. All the tumors studied sho ved significantly increased numbers of PCNA-positive eells when compared with normal epidermis and characteristic distribution pattern. of PCNA-positive cells. Most cases of actinic keratosis exhibited the basal dysplastic pattern, but Bo wenoid variants showed diffuse dysplastic pattern. Karatoacanthoma revealed the marginal pattern and Bowens disease showed the diffuse dysplastic pattern. Well-differentiated squamous cell carcinoria showed the basal dysplastic pattern, while poorly differentiated squamous cell carcinoma revealed d ffuse dysplastic pattern. Conclusion : Our results suggest that p53 mutation is a common and early genetic change in the epidermal tumorigenesis and may be used as a good marker for malignan transformation, but it does not seem to correlate with the biollagic behavior or prognosis of epidermal neoplasms. PCNA, which is considered as a proliferation-relaited marker, was expressed with chavaceristic distribution patterns according to the type of tumors, but the frequency of PCNA expression is unlikely to reflct the malignant potential of epidermal neoplasms. (Kor J Dermatol 1994; 32(4) ; 562-573)
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오준규 ( Jun Gyu Oh ),전호수 ( Ho Su Chun ),윤재일 ( Jai Il Youn ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.3
Actinic reticuloid is a rare, chronic photosensitivity dermatosis with clinical and histologic femtures resembling a cutaneous T cell lymphoma. Phototesting in these patients typically reveals extreme sensitivity to UVB, to UVA, and sometimes to visible light. has site of lymphomatoid histologic appearance, actinic reticuloid is now regarded as a histologic arant of chronic actinic dermatitis, which is the spectriam of several photosensitivity dermatosis, delet to its benign course and transition to or from other photosensitivity dermatosis. We present a case of actinic veticuloid in 58-year-old male, who has severely edematous infiltrated lichenified erytherratous patches on sun-exposed skin, lynptmatoid histologic features with selective T cell infiltrat,ion, and selective photosensitivity to UV. (Kor J Dermatol 1995;33(3): 534-539)
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Isoniazid 치료에 반응한 하지의 염증성 결절에 대한 임상 및 병리조직학적 관찰
조광현(Kwang Hyun Cho),전호수(Ho Su Chun),이주흥(Joo Heung Ree),이승철(Seung Chul Lee) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5
We performed a clinicopathological study of nineteen patients with chronic inflammatory nodose lesions of the legs which responded to the treatment with isolniazid. The results were summarized as follows: 1. Seven patients had a personal or family history of tuberculcsis and all patients showed a high tuberculin sensitivity. But, no one showed the evidence of active pulmonary tuberculosis. 2. The inflammatory nodules and swelling of the legs were resolved within 12 months in all cases. Resolution of the nodules was more rapid than that of leg swelling. 3. The clinical characteristics of the patients with chronic inflanimatory nodules were the same as those of the cases with erythema nodosum or erytiema induratum reported previously in Korea. The basic histopathologic process of inflarr matory nodules seemed to be vasculitis. (Kor J Dermatol 1992;30(5):644-650)
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조광현(Kwang Hyun Cho),전호수(Ho Su Chun),김선훈(Seon Hoon Kim),박경찬(Kyung Chan Park),김규한(Kyu Han Kim),이승철(Seung Chul Lee),지제근(Je Geun Chil) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.4
Background : since congenital nevi may not always be identified clirically, it remains a challange for histologists to separate an acquired from a congehital nevus. The camparative histologic feature of congenital and acquired lesions have been described by several authors. Objective : In an attempt to establish reliable microscopic recognition of congenital nevi, the histologic features of 52 congenital melanocytic nevi were studied. Material and methods By reviewing HMB slides, histologic paterns were observed depending on the extent of nevus cell infiltration. An immunohistochemical study wi h anti S-100 protein and HMB-45 antibody was also performed. Results : Diffuse infiltratien of upper and lower dermis with nevu. cells was observed in 21 cases (40.0%). Nevus cell infiltration of appendages and neurovascular structures was observed in 29 cases (55.8%). Indian filing of dermal nevus cells was observed in 33 casesl(64.7%). Epidermis showed elongation of rete ridges in 36 ca.es(69.2%). Immunohistochemical staining with HMB 45 showed a positive raction in 9 cases out of 51 having dermal nevus cells, and epidemal melanocytes showed positive reaction in 20 cases. Conclusion : Congenital melanocytie nevi can be classified by histolcgic appearance into several patterns. Nevus cells had a trend to infiltrate into the deeper dermis as the clinieal size increrased. Nevus cell infiltration of appendages and neurovascular structure was a common finding in congenital melanocytic nevi. (Kor J Dermatol 1993;31(4):523-531)
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김병수 ( Byung Su Kim ),조광현 ( Kwang Hyun Cho ),전호수 ( Ho Su Chun ),이일수 ( Eil Soo Lee ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3
Reactive perforating collagenosis(RPC) is one of the range of essential perforating disorders and is characterized by the transepithelial elimination of altered collagen. Two types have been recognized: the childhood(inherited) form and the adult(acquired) form. The acquired form is non-familial and is associated with various systemic disorders such as diabetes mellitus or nephropathy. We report four cases of acquired RPC. All have diabetic nephropathy and three have liver disease. (Kor J Dermatol 1996;34(3) 463-467)
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