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Takashi Yagi,Masaki Mizuno,Hiroto Kageyama,Kotaro Tatebayashi,Toshiki Endo,Yasuhiro Takeshima,Motoyuki Iwasaki,Ryu Kurokawa,Keisuke Takai,Misao Nishikawa,Kazutoshi Hida 대한척추신경외과학회 2023 Neurospine Vol.20 No.3
Objective: This study aimed to analyze the clinical characteristics, treatment strategies, and surgical outcomes of subependymoma patients from the 2022 Neurospinal Society of Japan multicenter intramedullary spinal cord tumor study. Methods: Twenty-six patients with spinal cord subependymoma who were included in the index study of 1,033 patients were retrospectively analyzed. Results: Mean patient age was 49.4 years. Seventeen patients were men and 9 were women. Sensory disturbance was reported in 22 patients and motor weakness in 18. Median duration of symptoms was 24 months. The tumor was eccentrically located in 19 patients (73.1%) and unilateral in 17 (65.4%). Gross total resection was achieved in 6 patients (23.1%). The same rate for ependymoma patients in the index study was significantly higher (74.8%). Median follow-up was 40.5 months (interquartile range, 18–68 months). In 2 patients who underwent only partial resection, reoperation was required owing to progression 68 and 90 months after surgery, respectively. No recurrence occurred in patients who underwent gross total resection. Five patients experienced neurological worsening after surgery. Conclusion: Although spinal cord subependymoma can be difficult to distinguish from other intramedullary spinal cord lesions before surgery, it is characterized by an indolent clinical course and eccentric location. Surgical treatment should prioritize functional preservation because the prognosis is good even after subtotal resection.
일본원숭이의 리보솜 단백질 S4 유전자의 분자적 클로닝 및 진화적 분석
김희수(Heui Soo Kim),(Takashi Kageyama),(Osamu Takenaka) 한국유전학회 2001 Genes & Genomics Vol.23 No.1
N/A We cloned and sequenced the cDNA encoding ribosomal protein S4 (RPS4) from testis cDNA library of the Japanese monkey. The monkey RPS4Y gene encodes a deduced protein of 263 amino acids and share 92.8% and 95.4% amino acid sequence identities with the deduced mouse Rps4 and human RPS4Y. Northern blot analysis of poly (A) mRNA from the Japanese monkey revealed approximately 1.0 kb transcript. Molecular evolutionary rate was 0.2 ∼ 0.3 × 10-9/site/year in the Japanese monkey. This value was at least three fold lower than that of the TSPY and SRY genes of human Y chromosome, suggesting that the RPS4Y gene has been evolved conservatively during primate evolution.
Kang, Kyung-Hwa,Higashino, Atsunori,Kim, Heui-Soo,Lee, Yong-Tae,Kageyama, Takashi Blackwell Publishing Ltd 2009 Journal of medical primatology Vol.38 No.2
<P>Abstract</P><P>Background </P><P>Adiponectin is an adipocyte-derived hormone that affects regulation of metabolic syndrome such as insulin resistance, type-2 diabetes, and obesity. It functions via seven transmembrane domain receptors [i.e., adiponectin receptors 1 (AdipoR1) and 2 (AdipoR2)] that have been scarcely investigated in non-human primates.</P><P>Methods </P><P>Molecular cloning of cDNAs for adiponectin, AdipoR1, and AdipoR2 that included the whole protein-coding region in the Japanese monkey, <I>Macaca fuscata</I>, was carried out. Tissue-specific expression of respective genes was analyzed with Northern blot hybridization.</P><P>Results </P><P>The essential Cys36 and four lysine residues in adiponectin, and transmembrane-spanning domains in AdipoR1 and AdipoR2 appear well conserved. While adiponectin mRNA is expressed only in adipose tissues, AdipoR1 mRNA was found to be expressed in various tissues including the brain.</P><P>Conclusions </P><P>These results significantly add to the understanding of the molecular basis of obesity-related adipokines and their receptors in non-human primates.</P>