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Anti-Melanogenic Effect from Submerged Mycelial Cultures of Ganoderma weberianum
( Ying-jang Lai ),( Kai-di Hsu ),( Tzu-jung Huang ),( Chang-wei Hsieh ),( Yu-hin Chan ),( Kuan-chen Cheng ) 한국균학회 2019 Mycobiology Vol.47 No.1
Compounds from Lingzhi has been demonstrated the ability for inhibiting tyrosinase (a key enzyme in melanogenesis) activity. In this study, we investigated the anti-melanogenic activity from the submerged mycelial culture of Ganoderma weberianum and elucidated the skin lightening mechanism by B16-F10 murine melanoma cells. From the cellular context, several fractionated mycelium samples exhibited anti-melanogenic activity by reducing more than 40% extracellular melanin content of B16-F10 melanoma cells. In particular, the fractionated chloroform extract (CF-F3) inhibited both secreted and intracellular melanin with the lowest dosage (25ppm). Further analysis demonstrated that CF-F3 inhibited cellular tyrosinase activity without altering its protein expression. Taken together, our study has demonstrated that the chemical extracts from submerged mycelial culture of G. weberianum have the potential to serve as an alternative anti-melanogenic agent.
Ying-Jang Lai,Shu-Hsien Tsai,Ming-Yi Lee 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.4
Twelve Lactobacillus strains isolated fromsorghum distillery residue (SDR) pickled cabbage werestudied for their in vitro scavenging activity against hydroxylradicals and DPPH free radicals, inhibition of lipidperoxidation, and their resistance to hydrogen peroxide incell lysate or intact cells. Lactobacillus brevis D7, at a doseof 1010 CFU/mL, showed the highest hydroxyl radical andDPPH scavenging activities, as well as total antioxidativeactivity, with inhibition rates of 51.2, 44.9, and 65.2%,respectively in intact cells. On the other hand, the L. brevisD7 strain was the most resistant against hydrogen peroxide. L. brevis D7 isolated from SDR pickled cabbage should beconsidered as a potential antioxidant to be used infunctional foods. Correlation analysis showed that DPPHfree radical scavenging activity is a potential screeningindicator for high exopolysaccharide (EPS) producingLactobacillus species.