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RISS 인기검색어
- 검색키워드
- 저자 : ( Yasuko Obata ) (검색결과 3 건)
- 무료
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( Yasuko Obata ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Lipid lamellar structure in intercellular space of stratum corneum is recognized as main physical barriers against dehydration and invasion of foreign substances. For development of effective transdermal drug delivery, it is necessary to decreasethosebarrierstemporally and reversibly. Co-administration of components which has drug absorption enhancing effect is one of the essential methodologies to increase absorption of drugs via skin. We have determined the change in lipid lamellar structure by synchrotron X-ray diffraction. Lipids in stratum corneum are only 10% in weight and possibleamount of stratum corneum utilize in experiments is very small. Thus, long exposure is necessary and obtained data might be noisy in X-ray diffraction equipment in laboratory. When the stratum corneum was pretreated by l-menthol, lipid lateral packing became liquid crystal. It was considered that disorder of lamellar structure brought about increasing in drug permeation. It means that the lipid lamellar structure is one of the key parameters to evaluate physical barrier function of the skin. Lamellar structure in lipid model prepared by typical lipids in stratum corneum was also determined using synchrotron X-ray diffraction. In case of skin disease model, lateral packing was looser than that of normal skin model. It was agreed well with known data which showed greater TEWL value in disease skin. The structure analysis of lipid lamellar structure employing synchrotron X-ray diffraction is thought to be ameaningful technique possibly applied for promoting mechanism study of transdermal absorption enhancer and evaluation of barrier function of the skin.
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( Yasuko Obata ) 한국피부장벽학회 2018 한국피부장벽학회지 Vol.20 No.2
Lamellar structure of intercellular lipids in stratum corneum is considered to be the essential physical barrier to protect living body from dehydration, invasion of hazards and permeation of compounds. The intercellular lipid of the human stratum corneum form a long period lamellar of about 13 nm and a short period lamellar of about 6 nm, and hexagonal and orthorhombic are known as a packing structure. To observe those structure, synchrotron X-ray diffraction is considered to be powerful tool. There observed phase transition of liquidation of orthorhombic packing (~40 ℃), solubilization of long lamellar and high-temperature hexagonal (~50 ℃), liquidation of short lamellar (~70 ℃) and solubilization of high-temperature hexagonal (~80 ℃). These structural changes are thought to be closely related to the barrier function of the skin. When menthol was administered to skin surface, the nanostructure of the intercellular lipids became liquid crystal. That is, the permeability of the substance was related to the rigidness of the lamellar structure. Furthermore, in experiments with lipid models using typical intercellular lipids, the mode of action could be different depending on the stereo activity of menthol. Liquid crystallization of the lamellar structure is one way to alleviate the barrier function of the skin. Therefore, by devising the components and mixing ratio of the transdermal/cosmetic formulation, it becomes possible for development of effective formulation.
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Synchrotron X-ray Diffraction Study of Lipid Lamellar Structure in Stratum Corneum
( Yasuko Obata ),( Yoshinori Onuki ),( Kozo Takayama ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Lipid lamellar structure in intercellular space of stratum corneum is recognized as main physical barriers against dehydration and invasion of foreign substances. For development of effective transdermal drug delivery, it is necessary to decrease those barriers temporally and reversibly. Co-administration of components which has drug absorption enhancing effect is one of the essential methodologies to increase absorption of drugs via skin. We have determined the change in lipid lamellar structure by synchrotron X-ray diffraction. Lipids in stratum corneum are only 10% in weight and possible amount of stratum corneum utilize in experiments is very small. Thus, long exposure is necessary and obtained data might be noisy in X-ray diffraction equipment in laboratory. When the stratum corneum was pretreated by l-menthol, lipid lateral packing became liquid crystal. It was considered that disorder of lamellar structure brought about increasing in drug permeation. It means that the lipid lamellar structure is one of the key parameters to evaluate physical barrier function of the skin. Lamellar structure in lipid model prepared by typical lipids in stratum corneum was also determined using synchrotron X-ray diffraction. In case of skin disease model, lateral packing was looser than that of normal skin model. It was agreed well with known data which showed greater TEWL value in disease skin. The structure analysis of lipid lamellar structure employing synchrotron X-ray diffraction is thought to be a meaningful technique possibly applied for promoting mechanism study of transdermal absorption enhancer and evaluation of barrier function of the skin.
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