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( Ui Hyeon Jo ),( Jung Min Moon ),( Jin Yong Lee ),( Seong-joon Koh ),( Sungchan Kang ),( Hosim Soh ),( Hyun Jung Lee ),( Jong Pil Im ),( Joo Sung Kim ),( Hyunsun Park ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Emerging data suggest that inflammatory bowel disease (IBD) and psoriasis are associated, sharing common genetic predispositions and immunologic mechanisms. Objectives: We aimed to investigate the risk of developing psoriasis in IBD patients compared to controls without IBD. Methods: Using the Korean insurance data, patients diagnosed with Crohn’s disease(CD) or ulcerative colitis(UC) between 2005 and 2008 were age- and sex-matched 1:4 to non-IBD subjects from 2003 to 2018. We investigated newly diagnosed psoriasis from 2009 to 2018. Incidence rates were calculated and risk of psoriasis was assessed with multivariate cox regression models. Results: During nearly a decade of follow-up, 20,152 IBD patients were identified [14,619 UC and 5,533 CD]. Among them, 439 patients were newly diagnosed with psoriasis (incidence rate of 217.68 and 228.62 per 100,000 person-years for UC and CD, respectively). The psoriasis risk was higher in IBD patients than in the matched controls (aHR 2.95, 95% CI 2.60-3.33). Moreover, IBD patients aged <30 years were at a higher risk (aHR 3.35; 95% CI, 2.58-4.35). Sensitivity analysis of tumor necrosis factor inhibitor-naïve patients revealed consistent results. Conclusion: IBD patients were more likely to develop psoriasis compared to non-IBD subjects, with younger patients at a particular risk. Inspection of cutaneous manifestation and dermatological consultation may be helpful in IBD patients at risk.
Combination therapy of CO<sub>2</sub> fractional laser and topical agent on pincer nails
( Ui Hyeon Jo ),( Ye Eun Kim ),( Hyunsun Park ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Pincer nail is the transverse overcurvature of the nail plate. Both conservative and surgical treatments can be used to treat pincer nail. However, there are no reports regarding the non-surgical, laser treatment of pincer nail. Objectives: To evaluate the efficacy and adverse effects of combination of CO<sub>2</sub> fractional laser and topical agent on pincer nail. Methods: Eleven pincer nails (All great toenails) were treated with CO<sub>2</sub> fractional laser. An antifungal agent (in case of co-existing onychomycosis) or 20% urea cream were applied to the toenails. We evaluated the difference of the width index, height index, nail angle, and the level of pain before and after treatment. All adverse events and recurrence were observed until the last follow-up visit. Results: The mean number of laser treatments was 2.27. The mean follow-up period after the last treatment was 18.36 weeks. The width index, height index, and nail angle was significantly changed after the treatment. The width index increased by 0.16 (p-value 0.0016), the height index decreased by 1.89 (p-value 0.008), and the nail angle increased by 29.60° (p-value 0.005). The level of pain was reduced in all cases. There were no serious adverse events. Conclusion: CO<sub>2</sub> fractional laser and topical agent combination therapy can be an effective and tolerable treatment for pincer nail. To confirm this result, larger studies with long-term observation are needed.
( Ui Hyeon Jo ),( Jin Yong Lee ),( Hanjae Lee ),( Do-yeop Kim ),( Sungchan Kang ),( Seong-joon Koh ),( Hyunsun Park ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Inflammatory bowel disease (IBD) presents with various extraintestinal manifestations, especially skin diseases. Objectives: We aimed to identify the epidemiology and risk of developing skin manifestations in patients with IBD. Methods: We used Korean National Health Insurance Claims database and selected patients with IBD and age/sex-matched non-IBD subjects using the diagnosis code and prescription records of IBD-specific medications from 2013 to 2017. The prevalence and risk of concurrent skin diseases were estimated. Results: A total of 64,837 patients with IBD was identified. Among 3 categories of reactive, inflammatory, and autoimmune skin diseases, reactive skin eruptions including pyoderma gangrenosum and erythema nodosum were associated with IBD with highest odds ratios. Inflammatory skin diseases including rosacea, psoriasis, atopic dermatitis, hidradenitis suppurativa, and acne conglobata were significantly associated with IBD. The patients with IBD also had a higher risk of autoimmune skin diseases including vitiligo and alopecia areata than non-IBD subjects. Conclusion: This population-based study suggests that IBD was related to various skin diseases including reactive, inflammatory, and autoimmune skin diseases. Considering these relationships can allow better management of patients with IBD and comorbid skin diseases.
Human papillomavirus infection signs in genital epidermal cysts: a preliminary study
( Ui Hyeon Jo ),( Ye Eun Kim ),( Hyunsun Park ),( Soyun Cho ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Human papillomavirus(HPV) is associated with some cases of palmoplantar epidermal cysts and suggested to the cyst formation. Recently, a case of HPV-associated epidermal cyst in the genitalia was also reported. Objectives: To evaluate and compare HPV infection sign of the plantar and genital epidermal cysts. Methods: We retrospectively reviewed plantar and genital epidermal cyst cases. We evaluated their histopathologic characteristics and HPV positivity using immunohistochemistry. Results: Sixty cases (20 plantar, 40 genital) were included in this study. Parakeratotic nuclei within keratinous substances were present in 17 of 20 plantar cysts versus 9 of 40 genital cysts (P<0.001). Vacuolar structures in keratinous mass were seen in 7 of 20 plantar versus 6 of 40 genital cysts (P=0.076). Intracytoplasmic eosinophilic bodies in cells of cyst wall were present in 8 of 20 plantar versus 2 of 40 genital cysts (P=0.001). Six of 20 (30%) plantar epidermal cysts had all of the aforementioned histopathologic findings and demonstrated HPV positivity, whereas no genital epidermal cyst did. Conclusion: Histopathologic signs indicative of HPV infection were rarely seen in genital epidermal cysts, compared to plantar epidermal cysts. HPV is unlikely to have a general pathogenic role in the genital epidermal cyst.