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Bio-functions of Marine Carotenoids
Masashi Hosokawa,Tomoko Okada,Nana Mikami,Izumi Konishi,Kazuo Miyashita 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.1
Carotenoids being most important pigments among those occurring in nature, have received increased interest owing to their beneficial effects on human health. An effort is made to review marine carotenoids as important bioactive compounds with reference to their presence, chemical, and biofunctional benefits they afford. The potential beneficial effects of marine carotenoids were particularly focused on astaxanthin and fucoxanthin, major marine carotenoids found in marine animals and aquatic plants, respectively. Both carotenoids show strong antioxidant activity which is attributed to quenching singlet oxygen and scavenging free radicals. The potential role of the carotenoids as dietary antioxidants has been suggested as being one of the main mechanism by which they afford their beneficial health effects such as anticancer activity and antiinflammatory effect. Only recently, antiobesity effect and antidiabetic effect have been noted as specific and novel biofunctions of fucoxanthin. Nutrigenomic study reveals that fucoxanthin induces uncoupling protein 1 (UCP1) expression in white adipose tissue (WAT) mitochondria to lead to oxidation of fatty acids and heat production in WAT. Fucoxanthin improves insulin resistance and decreases blood glucose level, at least in part, through the down-regulation of tumor necrosis factor α (TNFα) in WAT of animals.
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( Kunihiro Hayakawa ),( Keigo Ikeda ),( Maki Fujishiro ),( Yuko Yoshida ),( Takuya Hirai ),( Hiroshi Tsushima ),( Tomoko Miyashita ),( Shinji Morimoto ),( Yasushi Suga ),( Kenji Takamori ),( Hideoki O 대한피부과학회 2018 Annals of Dermatology Vol.30 No.1
Background: Connective tissue growth factor (CTGF) is a multifunctional cellular protein and playing a role as a central mediator in tissue remodeling and fibrosis. The physiological function of CTGF in psoriasis is unknown. Objective: The purpose of this study was to investigate the function of CTGF in psoriasis using the established imiquimod (IMQ)- induced psoriasis murine model and psoriasis patients. Methods: Anti-CTGF monoclonal antibody was applied to IMQ induced psoriasis mice and those skin were clinically, pathologically and immunologically analyzed. Additionally, CTGF expression was analyzes using skin samples and plasma from psoriasis patients. Results: CTGF expression was observed in the dermis from both IMQ-induced psoriatic mice and psoriasis patients. CTGF inhibition using an anti-CTGF antibody slightly worsened IMQ-induced dermatitis. In addition, the increase of CTGF showed tendency to suppress the psoriatic dermatitis through inhibition of suprabasal cells proliferation and macrophage infiltration in the skin. CTGF was also detected significantly higher in plasma from psoriasis patients comparing with healthy control. Conclusion: Our findings suggest that CTGF could contribute to the healing rather than the worsening of psoriasis skin lesions. (Ann Dermatol 30(1) 47∼53, 2018)
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