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Investigation of Bioactivity Mechanism of Flavonoids in Cancer Cells
( Kosei Yamauchi ),( Ayaka Tsuchiya ),( Tohru Mitsunaga ) 한국목재공학회 2021 한국목재공학회 학술발표논문집 Vol.2021 No.1
Quercetin is a flavonoid present as a glycoside in various fruits, vegetables as well as wood. Numerous studies have demonstrated that quercetin exhibits a variety of pharmacological effects including antioxidant, anti-inflammatory, and anti-cancer properties. The melanogenesis stimulatory activity and metastasis inhibitory activity of the quercetin derivatives were elucidated. Nineteen quercetin derivatives have been synthesized in order to investigate structure-activity relationships on the effect of melanogenesis and metastasis in B16 melanoma cells. 3,4’,7-O-trimethylquercetin (TMQ) significantly stimulated the extracellular melanin production. The compound stimulated melanosome transportation as well as the melanin synthesis in the cells. TMQ inhibited the migration in B16 melanoma cells. Additionally, it also inhibited migration and invasion in human ovarian cancer cell lines due to regulating the expression of MMP-2 and uPA that is relating to the metastasis. The target proteins of the methylquercetin were isolated and identified using pull down method in order to elucidate the direct mechanism. The investigation of binding site and energy between quercetin derivatives and the protein were under going.
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