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( Jung Min Bae ),( Sang Ho Oh ),( Hee Young Kang ),( Young Wook Ryoo ),( Cheng-che E. Lan ),( Lei-hong Xiang ),( Ki-ho Kim ),( Tamio Suzuki ),( Ichiro Katayama ),( Seung-chul Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Patients with vitiligo are more likely to have limited involvement than widespread one. Therefore, localized treatment is essential and a reliable instrument for target evaluation is needed. Objectives: To validate the accuracy and reliability of the Vitiligo Extent Score for a Target Area (VESTA) for assessing treatment response in a target lesion. Methods: A validation study was performed for 17 pairs of vitiligo images (pre- and post-treatment) between March and April 2017 by 65 dermatologists in 10 institutes, using both a rough estimate and the VESTA. Accuracy was evaluated by calculating concordance correlation coefficients (CCCs) between the true values and each measurement. Inter- and intra-rater reliabilities were assessed by deriving intraclass correlation coefficients (ICCs). The smallest detectable change (SDC) was calculated with each coefficient. Results: The VESTA (CCC: 0.949, 95% confidence interval [CI] 0.942-0.955) was significantly more accurate than the rough estimate (CCC: 0.896, 95% CI 0.883-0.908). These corresponded to an SDC95 of 1.5% for the VESTA and 4.1% for the rough estimate. Inter-rater reliability showed an ICC of 0.928 (SDC95: 12.8%) for the VESTA and 0.900 (SDC95: 19.6%) for the rough estimate. Intra-rater reliability showed an ICC of 0.944 (SDC95: 1.7%) for the VESTA and 0.943 (SDC95: 1.8%) for the rough estimate. Conclusion: The VESTA afforded accurate and reliable assessments of treatment response in a target area.