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RISS 인기검색어
- 검색키워드
- 저자 : ( Ta-hui Lin ) (검색결과 5 건)
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Experimental Simulations on Combustion Chamber Deposits of Spray Flames
( Ta Hui Lin ),( Wei Dong Hsieh ) 한국액체미립화학회 2010 한국액체미립화학회 학술강연회 논문집 Vol.2010 No.-
Combustion chamber deposits are usually observed in various internal combustion devices. They result in negative effects on the operation and performance of these devices. Study of deposits formed in the internal combustion devices is not easy and usually time-consuming. Therefore, we proposed an experimental method to simulate the deposit formation on the combustion chamber wall by considering a spray flame impinging onto a stagnation plate. Using this method, deposits can be readily generated on the stagnation plate, and it is easy to extract them for further chemical or physical analysis. In this paper, we first focused on the gasoline deposits, and later on the diesel deposits, generated on the water-cooled stagnation plate. The comparisons of gasoline deposits from the stagnation spray flames and from actual CFR engine tests exhibited good qualitative correlations. Concerning the diesel deposits, they had great difference with the gasoline deposits in the appearance. However, the effect of the cooling water (the wall temperature) and deposit growth history for the diesel deposits were basically similar to those of the gasoline deposits. This method may be used as a preliminary test on understanding deposit formation or for fuel formula developing. However, further studies are needed to justify its applicability to real engine CCD simulation.
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Chih-Ta Chen,Li-Zhu Liao,Ching-Hui Lu,Yung-Hsuan Huang,Yu-Kie Lin,Jung-Hsin Lin,Lu-Ping Chow 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Limited therapeutic options are available for advanced-stage hepatocellular carcinoma owing to its poor diagnosis. Drug resistance to sorafenib, the only available targeted agent, is commonly reported. The comprehensive elucidation of the mechanisms underlying sorafenib resistance may thus aid in the development of more efficacious therapeutic agents. To clarify the signaling changes contributing to resistance, we applied quantitative phosphoproteomics to analyze the differential phosphorylation changes between parental and sorafenib-resistant HuH-7 cells. Consequently, an average of ~1500 differential phosphoproteins were identified and quantified, among which 533 were significantly upregulated in resistant cells. Further bioinformatic integration via functional categorization annotation, pathway enrichment and interaction linkage analysis led to the discovery of alterations in pathways associated with cell adhesion and motility, cell survival and cell growth and the identification of a novel target, EphA2, in resistant HuH-7R cells. In vitro functional analysis indicated that the suppression of EphA2 function impairs cell proliferation and motility and, most importantly, overcomes sorafenib resistance. The attenuation of sorafenib resistance may be achieved prior to its development through the modulation of EphA2 and the subsequent inhibition of Akt activity. Binding analyses and in silico modeling revealed a ligand mimic lead compound, prazosin, that could abate the ligand-independent oncogenic activity of EphA2. Finally, data obtained from in vivo animal models verified that the simultaneous inhibition of EphA2 with sorafenib treatment can effectively overcome sorafenib resistance and extend the projected survival of resistant tumor-bearing mice. Thus our findings regarding the targeting of EphA2 may provide an effective approach for overcoming sorafenib resistance and may contribute to the management of advanced hepatocellular carcinoma.
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Impact of Two Drops on a Dry Surface
( Chun-kuei Chen ),( Sheng-qi Chen ),( Ta-hui Lin ) 한국액체미립화학회 2017 한국액체미립화학회 학술강연회 논문집 Vol.2017 No.-
A group of two streamwise drops could be successfully generated by using the free-falling drops technique incorporated with a drop severance device in this study. Therefore, the impact characteristics of a group of two streamwise drops impinging on a dry surface will be experimentally examined and analyzed in this study. The water was considered as the working fluid, and the velocity of the drop was fixed to 1.9 ± 0.1 m/s. The initial diameter of the drop was fixed to 930 ± 30 ㎛ and 1025 ± 5 ㎛, respectively. This study focused on four cases of two drops impinging on a dry surface which classified by space difference (ㅿt). Conditions respectively being Case 1: single drop impinging, Case 2: ㅿt = 0.5 ms, Case 3: ㅿt = 1 ms and Case 4: ㅿt = 2.5 ms. The results showed two drops impinging on a dry surface for Case 2~4, the maximum spread diameter of drop was 1.3 times compared with the single drop at the same initial drop diameter, but the variation process of two drops impinging on a dry surface was different to the single drop.
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Drop Interaction in a Burning Drops Stream
( Wei Dong Hsieh ),( Chun Kuei Chen ),( Ta Hui Lin ),( Shuhn Shyurng Hou ) 한국액체미립화학회 2010 한국액체미립화학회 학술강연회 논문집 Vol.2010 No.-
In a spray combustion flow field, a burning drop may interact with other drops flowing in parallel streams or along the same flow stream. Many studies on drop interaction in parallel streams were reported. However, upstream/downstream interaction of drops along a burning drops stream has not been well studied literately. To understand such interesting phenomena, we established an experimental system to examine a burning dodecane drops stream with variable drop inter-spaces in a high-temperature oxygen-rich environment. Effects of the drop inter-space (s/di) and the oxygen concentration ΩO2) in the hot environment on the interaction of burning drops were investigated in the study. Drop inter-spaces were chosen to be 2.5, 5, 10, 30 and 100. Oxygen concentrations of 21%, 25% and 30% in the hot environment were considered. The flame propagation and interactions between the burning drops in the stream were performed. Results showed that the diffusion flame enclosing the drops stream is narrowed with the increase of ΩO2 whereas effect of ΩO2 is not obvious when s/di>30. The overall flame length was longer for lower s/di due to flame propagating across the drops. Evaporation rates remains constant when s/di>30 indicating a weak interaction of drops along the same stream.
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The Transition from Dripping to Jetting of a Water Jet Under Rigid Body Rotation
( Chun-chia Chang ),( Chun-kuei Chen ),( Ta-hui Lin ) 한국액체미립화학회 2017 한국액체미립화학회 학술강연회 논문집 Vol.2017 No.-
This research is dedicated to analyzing the characteristic of a liquid jet under various conditions, for example, different flow rate and rotating speed. In this study, we found out that the imposed rotation would shorten the breakup length of a liquid jet due to its extra disturbance. On the other hand, hysteresis behavior occurs when using relatively large nozzle diameter, which represents that the critical flow rate of the transition from dripping to jetting is different to that from jetting to dripping. Consequently, we further analyzed the critical rotating speed (Jetting→Dripping) and critical flow rate (Dripping→ Jetting) in this hysteresis zone. As for the last part of this study, the breakup patterns had been deducted, we can divided the breakup modes into three distinguished patterns basically by how the droplets are formed, which are steady formation, two-drop coalescence, multiple-drop coalescence, respectively. Last but not least, the mutual interaction between these three patterns and how the rotation affected the outcomes of a liquid jet are concluded in this research.
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