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P208 : Protective effect of red ginseng on the chemotherapy induced alopecia
( Long Quan Pi ),( Dong In Kim ),( Xing Hai Jin ),( Sungjoo Tommyhwang ),( Won Soo Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Hair loss is one of the most distressing side effectsof chemotherapy. Ginseng has been widely used as a medicinal herb in Asian countries. Ginseng is not only potent immunosuppressant but also modulate hair growth. Objectives: In this study, we investigated the effects of Korea red ginseng (KRG) on the prevention of chemotherapy- induced alopecia (CIA). Methods: First, we used cyclophosphamide (150mg/kg) to induce hair follicle dystrophy in C57BL/6 mouse as previously described. Then, we examined the effects of KRG on the regulation of cyclophosphamide induced hair follicle dystrophy in C57BL/6 mouse. Results: We confirmed that KRG induces active hair growth (anagen) in the back skin of C57BL/6 mice and showed that KRG also inhibits massive cyclophosphamide-induced premature catagen development in these mice. Conclusion: The results of this study suggest that KRG could be useful as a new alopecia-protectionstrategy, especially in the context of CIA.