Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

A New Sesame Variety, “Kangbaek” with Disease Resistance, Lodging Tolerence and High Yield

Kang-Bo Shim,Churl-Whan Kang,Suk-Bok Pae,Si-Kyu Lim,Yu-Young Lee,Duck-Yong Suh,Jae-Whan Rho,Jin Song,Dong-Whi Kim,Ho-Young Kim 한국육종학회 2005 한국육종학회지 Vol.37 No.5

A new sesame variety Kangbaek was developed from Yeongnam Agricultural Research Institute in 2004. Cros wasmade by lodging resistant SP9003-3 line to the F1with high yielding capacity, folowed by pedigree selection, yield test and RYT by the sesame breeding team at the National Insti-tute of Crop Science up to 2003. The variety showed higher disease resistance, especially phytophothra disease, and lodging resis-respectively. It's 1000 grains weight was about 2.54 g indicating 0.03 g heavier than that of Yangbaekkae, and it's oil content wasabout 52%. Kangbaek also contained total 7.65mg/g of such lignans as sesamin and sesamolin. The average yield of Kang-baek was 82 kg per 10a at the national-wide regional performance.

한국의 에너지와 환경 - 문제점과 장래전망

강석호 嶺南大學校 環境問題硏究所 1992 環境硏究 Vol.12 No.1

한국의 경제는 1970년 이후 급속히 성장하였고, 그 결과로 에너지 소비와 환경오염도 크게 증가하였다. 에너지 사용으로 인한 대기환경오염은 한국의 국내문제일 뿐만 아닐 전세계적인 문제가 되기 때문에, 이 논문에서는 에너지 사용으로 인한 환경오염을 연과시켜서 관찰하였다. 먼저 한국의 에너지 소비추세를 과거의 통계자료로부터 고찰하였고, 에너지공급과 환경오염의 장래상황을 전망하면서 SO₂, TSP 및 CO₂의 국지적 환경보전방안과 국제적 협조방안에 대한 기술적 과제들을 제안하였다. Korean economy has been prospering since 1970, consequently the energy consumption has increased much and the environment has been polluted severely. As its atmospheric environment, which is not of a regional interest but of a global one, has been rapidly polluted, the impacts of energy use on environmental pollution must be thoroughly reconsidered. In this article, the past trends of energy uses in Korea is reviewed with the statistical informations already published and the future prospects of the energy supply and the environmental perspectives are discussed with emphasis of the pollutants including the global warning effects of carbon dioxide gas, about which some international cooperations needed are suggested.

섬유필터에 의한 분진의 집진분리

강석호 嶺南大學校 工業技術硏究所 1988 연구보고 Vol.16 No.1

The commercially available nonwoven fibrous filter mats are used to collect the CaCO₃sample dust from the air stream. The collection efficiency and the grade efficiency in the air filtration are experimentally determined and compared with the analogous results calculated by the theoretical equations proposed by other researchers. The pressure drop measured across the filter mat is also discussed with the theoretically estimated one. The comparison between the two results are in a good agreement with each other. Effects of the fibre diameter and the inlet air velocity on the separation efficiency and on the pressure drop are also discussed.

二次元 畵面解析을 이용한 三次元空間의 固體粒子 濃度 測定範圍

강석호 嶺南大學校 工業技術硏究所 1982 연구보고 Vol.10 No.2

Optical measurements of particle size, its distribution, concentration, and velocity in the particulate handling processes are of great significance in recent years. The 2-dimensional optical images observed provide, with little precision, the particle characteristics in the 3-dimensional space of the volume element, in which the particle concentratioin plays a remarkable role in data acquisition of particle size concerned. Geometrical relationships between the 3-dimensional volume concentration and the 2-dimensional photographic obscuration are mathematically discussed, and the concentration criteria of the possible observation range to be applicable in particle characterization are experimentally determined. Above 5% of particle concentration in volume, the photographic images do not provide any sufficient results in the particle size measurement by the optical method.

Pd(0)를 이용한 고리 카보네이트의 친핵성 치환 반응 연구

강석구,박동철,전제호,노호식 성균관대학교 기초과학연구소 1993 論文集 Vol.44 No.2

촉매량의 Pd(0)존재하의 chiral allylic 그리고 dienylic 고리 카보네이트와 여러 가지 친핵성 치환체들의 치환 반응을 연구하였는데 이 치환 반응은 친핵체에 따라서 α-, γ-, 또는 ε-위치에 치환된 높은 위치 및 diastereoselection이 있는 반응임을 알았고 또한 이의 입체화학을 결정하였다. We studied the reactions of chiral allylic and dienylic cyclic carbonates with various nucleophiles in the presence of Pd(0)catalyst and found that substitution occurred at α-, γ-, ε-position with high regio-and diasteroselectirity depending on nucleophiles used.

활성탄(活性炭) 재생용(再生用) 연소로(燃燒爐)에 관한 연구(I) : 수직원형관로(垂直圓形管爐)내의 연소온도추산(燃燒溫度推算) Estimation of the Flue Gas Temperature in the Vertical Tubular Furnace

姜錫浩 嶺南大學校 工業技術硏究所 1976 연구보고 Vol.4 No.1

To regenerate the pelletized active carbon used in the waste water treatment, a vertical tubular furnace of 80cm. in length and of 3.5cm. in core diameter was designed to combust propane gas as heat source. Prior to the operation, it is desired to estimate the attainable temperature of the furnace. By means of a simple computer program with the aid of conventional energy-balance method, the temperature of the flue gas was estimated by varying the propane feed rate and the excess air ratio. Compared with the economic velocity of the gas flow, the propane gas feed rate may be limited under the trasition flow rate of the flue gas produced. The estimation was tried on the assumption that the steady-state heat transfer through the funace wall is kept and the temperatures of both sides of the inlet and the exit are nearly uniform throughout.

유리 纖維 Filter에 의한 粉塵의 分離 效率

姜錫浩,姜善泰 영남대학교 공업기술연구소 1985 연구보고 Vol.13 No.2

The separation efficiency curve of the sand dust in the fibrous air filter was estimated from the particle size data of the sample dust measured by means of the optical microscope. The estimated separation curve was affected by the number of the experimental runs, and by the counted number of the particle images on the microscopic photograghs taken for each experimental run. But, the dust collection and the particle size data measured were not so reproducible that the separation efficiency curves determined were very widely scattered from their mean values.

공기 싸이클론 분리 장치의 분체 분리 효율

姜錫浩,朴永孝,金珠浩,朱星浩 嶺南大學校 工業技術硏究所 1985 연구보고 Vol.13 No.1

The collection efficiency of the Lapple's standard-type cyclone separator was determined in order to investigate the effects of the particle size of the dust samples, the dust loading, and the air inlet velocity to the cyclone under the ambient conditions. The experimental conditions are in the following ranges; the air inlet velocity; 5 to 14.7 m/s, the particle sizes of the mono-dispersed system; 14 to 280 ㎛, the dust loading; 17.8 to 58.6 g/㎥, respectively. The collection efficiencies determined were compared with those predicted by the semi-empirical equations proposed earlier by Strauss (³) and by Licht et al, (⁴) and those are shown to be increased, as the particle size of the sample dusts and the air inlet velocity increase, respectively. However, the effect of the dust loading in the air could not be recognized, but slightly increased. For the poly-dispersed particulate samples, having a wide particle size distribution, the grade or separation efficiency curve was experimentally determined to specify more exactly the cyclone separation performance, and the result was discussed with the statistical analysis previously worked by Herrmann.(??)

(E)-γ-히드록시-α,β-불포화 슬폰과 니트릴의 합성

강석구,전제호 성균관대학교 기초과학연구소 1992 論文集 Vol.43 No.2

β,γ-에폭시슬폰과 β,γ-에폭시느트릴을 -78℃에서 THF를 용매로 LDA를 사용하여 탈 양성자-제거반응을 유도하면 선택적으로(E)-히드록시-α, β-불포화 니트릴을 좋은 수율로 각각 얻을 수 있었다. Deprotection-elimination of β, γ-epoxy sulfone and β, γ-epoxy nitrile with LDA in THF at -78℃ afforded (E)-γ-hydroxy-α, β-unsaturated sulfone and (E)-γ-hydroxy-α, β-unsaturated nitrile in good yields, respectively.