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- 저자 : ( Sergio Parra ) (검색결과 3 건)
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A novel excisional wound pain model for evaluation of analgesics in rats
( Sergio Parra ),( Vaidehi J. Thanawala ),( Ajay Rege ),( Heather Giles ) 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.2
Background: Management of pain from open wounds is a growing unmet healthcare need. However, the models available to study pain from wounds or to develop analgesics for the patients suffering from them have primarily relied on incisional models. Here, we present the first characterized and validated model of open wound pain. Methods: Unilateral full-skin excisional punch biopsy wounds on rat hind paws were evaluated for evoked pain using withdrawal responses to mechanical and thermal stimulation, and spontaneous pain was measured using hind paw weight distribution and guarding behavior. Evaluations were done before wounding (baseline) and 2-96 hours post-wounding. The model was validated by testing the effects of buprenorphine and carprofen. Results: Pain responses to all tests increased within 2 hours post-wounding and were sustained for at least 4 days. Buprenorphine caused a reversal of all four pain responses at 1 and 4 hours post-treatment compared to 0.9% saline (P < 0.001). Carprofen decreased the pain response to thermal stimulation at 1 (P ≤ 0.049) and 4 hours (P < 0.011) post-treatment compared to 0.9% saline, but not to mechanical stimulation. Conclusions: This is the first well-characterized and validated model of pain from open wounds and will allow study of the pathophysiology of pain in open wounds and the development of wound-specific analgesics.
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Clinical and biological analysis in graftless maxillary sinus lift
Marcelo Parra,Sergio Olate,Mario Cantín 대한구강악안면외과학회 2017 대한구강악안면외과학회지 Vol.43 No.4
Maxillary sinus lift for dental implant installation is a well-known and versatile technique; new techniques are presented based on the physiology of intrasinus bone repair. The aim of this review was to determine the status of graftless maxillary sinus lift and analyze its foundations and results. A search was conducted of the literature between 1995 and 2015 in the Medline, ScienceDirect, and SciELO databases using the keywords “maxillary sinus lift,” “blood clot,” “graftless maxillary sinus augmentation,” and “dental implant placement.” Ten articles were selected for our analysis of this technique and its results. Despite the limited information, cases that were followed for at least six months and up to four years had a 90% success rate. Published techniques included a lateral window, elevation of the sinus membrane, drilling and dental implant installation, descent of the membrane with variations in the installation of the lateral wall access and suturing. The physiology behind this new bone formation response and the results of the present research were also discussed. We concluded that this is a promising and viable technique under certain inclusion criteria.
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Methodology for Computer Security Incident Response Teams into IoT Strategy
( Alejandro Enciso Bernal ),( Sergio Mauricio Martínez Monterrubio ),( Javier Parra Fuente ),( Rubén González Crespo ),( Elena Verdú ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.5
At present, the Colombian government shares information on threats or vulnerabilities in the area of cybersecurity and cyberdefense, from other government agencies or departments, on an ad-hoc basis but not in real time, with the surveillance entities of the Government of the Republic of Colombia such as the Joint Command of Cybernetic Operations (CCOCI) and the Cybernetic Emergencies Response Team of Colombia (ColCERT). This research presents the MS-CSIRT (Management System Computer Security Incident Response Teams) methodology, that is used to unify the guidelines of a CSIRT towards a joint communication command in cybersecurity for the surveillance of Information Technology (IT), Technological Operations (TO), Internet Connection Sharing (ICS) or Internet of Things (IoT) infrastructures. This methodology evaluates the level of maturity, by means of a roadmap, to establish a CSIRT as a reference framework for government entities and as a guide for the areas of information security, IT and TO to strengthen the growth of the industry 4.0. This allows the organizations to draw a line of cybersecurity policy with scope, objectives, controls, metrics, procedures and use cases for the correct coordination between ColCERT and CCOCI, as support entities in cybersecurity, and the different companies (ICS, IoT, gas and energy, mining, maritime, agro-industrial, among others) or government agencies that use this methodology.
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