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( Lee K. K ),( Cho J. J ),( Choi J. D ),( Jeongchon-ri ),( Seonggeo-eup ),( Cheonan-si ),( Chungnam ) 대한화장품학회 1997 대한화장품학회지 Vol.23 No.2
Inhibitory effects of 200 medicinal plants on elastase activity were screened. Among the 200 plants, six plant extracts exhibited more than 65% of inhibition on elastase activity by their total methanol extracts at 1, 000㎍/㎖ as a final concentration. For six active plants including Areca catechu(IC<sub>50</sub>:42.4 ㎍/㎖), Cinnamonum cassia(IC<sub>50</sub>:208.7 ㎍/㎖), Myristica frograns(lC<sub>50</sub>:284.1 ㎍/㎖), Curcumma longa(lC<sub>50</sub>:398.4 ㎍/㎖), Alponia katsumadai(lC<sub>50</sub>:465.7 ㎍/㎖), and Dryopteris crassirrhizoma(IC<sub>50</sub>:714.4 ㎍/㎖), the inhibitory effects of their comsituents were examined on the activity of human leukocyte elastase, hyaluronidase and lipid peroxidation. In lipid peroxidation assay using TBA method, three of the 6 plants including Curcumma longa(lC<sub>50</sub>:45.5 ㎍/㎖), Areca Catechu(lC<sub>50</sub>:51.0 ㎍/㎖) and Alponia katsumadai(lC<sub>50</sub>:116.3 ㎍/㎖) exhibited more than 70% of inhibition at the concentration of 1, 000㎍/㎖, but only one plant, Areca Ctechu(lC<sub>50</sub>:563 ㎍/㎖) showed high inhibitory effect on hyaluronidase activity. The results suggest that medicinal plants showing several biological activities may be potent inhibitors of anti-aging process on skin and that might be useful for application in cosmetics.