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In vivo Trial of a Micro-angiographic PIV Technique for Hemodynamic Studies
Sang Joon Lee(이상준),Guk Bae Kim(김국배),Jin Pyung Lee(이진평) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5
The synchrotron X-ray PIV technique using a coherent synchrotron X-ray as a light source for PIV velocity field measurements has been utilized to investigate blood flows without any contrast materials or tracer particles. For applying this X-ray PIV method for in-vivo tests, bio-compatible hollow microcapsules were developed. The hollow inner space of the tracer, filled with air, plays a key role to induce epoch-making contrast enhancement based on X-ray refraction mechanism. Using the fabricated hollow microcapsules, we tried to apply the X-ray PIV method to the in-vivo visualization of blood flows in a rat. The hollow microcapsules used exclusively would make the synchrotron X-ray PIV method be more powerful and generally used in various flow imaging researches as a new-concept micro-angiographic PIV diagnosis method.
Kim, Sun-Young,Kim, Jae-Sung,Park, Hee-Sun,Cho, Moon-June,Kim, Ju-Ock,Kim, Jin-Whan,Song, Chang-Jun,Lim, Seung-Pyung,Jung, Sung-Soo 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.
The purpose of this prospective study was to determine whether using magnetic resonance imaging (MRI) for early screening for brain metastases (BM) can improve quality of life, survival in patients with non-small cell lung cancer (NSCLC). The study group comprised 183 patients newly diagnosed with NSCLC. All patients underwent limited brain MRI and routine workups. The control group comprised 131 patients with NSCLC who underwent limited brain MRI only if they had neurologic symptoms. The incidence of BM was 20.8% (38/183) in the study group and 4.6% (6/131) in the control group. The rate of upstaging based on the MRI data was 13.5% (15/111) overall and 15.9% (11/69) in patients that had been considered initially to be resectable surgically. There was no significant difference in survival outcome between the groups. Patients who had BM alone had a greater overall survival time (49 weeks) than those who had multiple systemic metastases (27 weeks; p=0.0307). In conclusions, limited brain MRI appears to be a useful, cost-effective method to screen for BM at the time of initial staging. And it may facilitate timely treatment of patients with NSCLC and improve their survival and quality of life.
CORRELATION BETWEEN THE TENSILE STRENGTH AND CORROSION BEHAVIOR OF HEAT TREATED ZR-1.0NB ALLOY
Kim, Tae-Kyu,Choi, Pyung-Sik,Yang, Sung-Ki,Lee, Chong-Tak,Sohn, Dong-Seong Korean Nuclear Society 2008 Nuclear Engineering and Technology Vol.40 No.6
The correlation between the tensile strength and corrosion behavior of Zr-1.0wt%Nb alloy heat treated at $480^{\circ}C$ for up to 32 hours was evaluated. The tensile strength at $400^{\circ}C$ was continuously reduced with an increasing heat treatment time, mainly due to a grain growth and a decreased area fraction of the precipitates. However, the corrosion resistance in an aqueous ammonia solution at $360^{\circ}C$ was enhanced, mainly due to the formation of $\beta$-Nb precipitates. It is thus concluded that a longer heat treatment time provides a better corrosion resistance while degrading the tensile strength.
Clinical Experiences of Transforaminal Balloon Decompression for Patients with Spinal Stenosis
( Sung Hoon Kim ),( Won Uk Koh ),( Soo Jin Park ),( Woo Jong Choi ),( Jeong Hun Suh ),( Jeong Gil Leem ),( Pyung Hwan Park ),( Jin Woo Shin ) 대한통증학회 2012 The Korean Journal of Pain Vol.25 No.1
Lumbar spinal stenosis is a commonly treated with epidural injections of local anesthetics and corticosteroids, however, these therapies may relieve Leg pain for weeks to months but do not influence functional status. Furthermore, the majority of patients report no substantial symptom change over the repeated treatment. Utilizing balloon catheters, we successfully treated with three patients who complained persistent symptoms despite repeated conventional steroid injections. Our results suggest that transforaminal decompression using a balloon catheter may have potential in the nonsurgical treatment of spinal stenosis by modifying the underlying pathophysiology. (Korean J Pain 2012; 25: 55-59)
Kim, Tae-Kyung,Lee, Jung-Eun,Park, Sun-Kyu,Lee, Kang-Woo,Seo, Ji-Seon,Im, Joo-Young,Kim, Sang-Tae,Lee, Joo-Yong,Kim, Yang-Hee,Lee, Ja-Kyeong,Han, Pyung-Lim Korean Society for Biochemistry and Molecular Bion 2012 Experimental and molecular medicine Vol.44 No.8
Adequate assessment of plaque deposition levels in the brain of mouse models of Alzheimer disease (AD) is required in many core issues of studies on AD, including studies on the mechanisms underlying plaque pathogenesis, identification of cellular factors modifying plaque pathology, and developments of anti-AD drugs. The present study was undertaken to quantitatively evaluate plaque deposition patterns in the brains of the two popular AD models, Tg2576 and Tg-APPswe/PS1dE9 mice. Coronally-cut brain sections of Tg2576 and Tg-APPswe/PS1dE9 mice were prepared and plaque depositions were visualized by staining with anti-amyloid ${\beta}$ peptides antibody. Microscopic images of plaque depositions in the prefrontal cortex, parietal cortex, piriform cortex and hippocampus were obtained and the number of plaques in each region was determined by a computer-aided image analysis method. A series of optical images representing a gradual increase of plaque deposition levels were selected in the four different brain regions and were assigned in each with a numerical grade of 1-6, where +1 was lowest and +6, highest, so that plaques per unit in $mm^2$ increased "sigmoidally" over the grading scales. Analyzing plaque depositions using the photographic plaque reference panels and a computer-aid image analysis method, it was demonstrated that the brains of Tg2576 mice started to accumulate predominantly small plaques, while the brains of Tg-APPswe/PS1dE9 mice deposited relatively large plaques.
감자유전자 StACRE의 분리 및 풋마름병 저항성 기능 검정
Sang Ryeol Park(박상렬),Eun-Mi Cha(차은미),Tae Hun Kim(김태훈),Seyoun Han(한세연),Duk-Ju Hwang(황덕주),Il-Pyung Ahn(안일평),Kwang-Soo Cho(조광수),Shin-Chul Bae(배신철) 한국생명과학회 2012 생명과학회지 Vol.22 No.2
Ralstonia solanacearum (Rs)에 의해 유발되는 풋마름병은 감자 재배 시 발병하는 주요 병 중의 하나이다. 감자에서 풋마름병 저항성관련 유전자를 찾기 위해 기존에 기능이 알려진 다른 가지과 작물의 기능 유사 유전체를 이용하여 StACRE (HM749652) 유전자를 분리하고 염기서열을 분석하였다. 분리한 StACRE의 발현양상을 분석하기 위해 병 저항성 유도 신호전달 물질인 SA와 풋마름병원균 Rs (KACC10722)를 처리한 감자에서 RNA를 추출하여 RT-PCR을 실시한 결과 이 유전자는 SA 처리에 의해 3시간 후부터, Rs에 의해서는 12시간 후부터 발현이 현저하게 증가하였다. 따라서, 감자에서 이 유전자의 생물학적인 기능을 분석하기 위해 Gateway System을 이용하여 과발현용 vector를 만든 후 과발현 형질전환 감자를 제작하고 풋마름병균인 Rs를 접종하여 병 저항성 기능을 검정 한 결과 대조구인 수미 감자에 비해 병 저항성이 증대하였다. Bacterial wilt (brown rot) caused by Ralstonia solanacearum (Rs) is one of the most devastating bacterial plant diseases in potatoes. To isolate bacterial wilt disease resistance-related genes from the potato, the StACRE (HM749652) gene was isolated and a sequenced search was performed using functional orthologs of Solanaceae from potatoes. StACRE is homologous to the tobacco NtACRE 132 protein and belongs to the ATL family involved in ubiquitination. To analyze the expression pattern of this gene, RT-PCR was performed with potato treated with salicylic acid (SA) and Rs (KACC 10722). StACRE was strongly induced 3 hours after treatment with SA and 12 hours after infection with Rs. To investigate its biological functions in the potato, we constructed a vector for overexpression in the potato by the Gateway system, and then generated transgenic potato plants. The gene expression of transgenic potato was analyzed by northern blot analysis. In the results of disease resistance assay in relation to bacterial wilt, StACRE overexpressed transgenic potato plants were shown to have more resistance than wild-type potato.