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The Radical Scavenging Effects of Stilbene Glucosides from Polygonum multiflorum
Ryu, Geon-Seek,Ju, Jeung-Hoon,Park, Yong-Ju,Ryu, Shi-Yong,Choi, Byoung-Wook,Lee, Bong-Ho The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.5
The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-Ο-$\beta$-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity ($IC_{50}$, 40 $\mu$M), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity ($IC_{50}$, 0.38 $\mu$M).
A clinicopathological analysis of metastasis in Korean acral melanomas
( Ryu Geon Wook ),( Jee-bum Lee ),( Seung-chul-lee ),( Young Ho Won ),( Sook Jung Yun ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: The prognosis of acral melanomas depends on metastasis. Objectives: The purpose of current study was to investigate the prognostic factors for metastasis of acral melanomas. Methods: We retrospectively reviewed all patients with melanoma located on acral sites from 1996-2016. Only patients who had followed-up for at least 3 years were included. We divided total 189 acral melanoma patients into groups of no metastasis, first lymph node metastasis, and first distant metastasis. Demographic and clinicopathological characteristics were obtained. Results: The median age was 63 years and 51.3% of patients were male. The number of patients who were diagnosed as melanoma in situ was 46 (24.3%), and that of invasive melanoma without metastasis was 29 (15.3%). Among 114 patients with invasive acral melanomas with metastasis, the first metastasis to regional lymph nodes was predominant (99, 86.8%), whereas the first metastasis to distant organs was detected in only 15 patients (13.2%). Acral melanomas deeper than T3 stages, ulceration, and higher mitotic rate more than 7 per square mm are associated with metastasis with statistical significance. However, there was no statistically significant difference in age, sex, site, height, and duration to the first metastasis among patient groups. Conclusion: Breslow thickness, ulceration and mitotic rate are significant prognostic factors for prediction of metastasis in acral melanomas.
A case of infantile bullous pemphigoid
( Geon Wook Ryu ),( Sook Jung Yun ),( Seung-chul Lee ),( Jee-bum Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Bullous pemphigoid(BP) is an autoimmune disease with subepidermal blister formation. It mostly occurs in the elderly and is extremely rare in infants. A male infant presented with tense bulla on trunk, hands, feet at birth. He has no family history and no sign of infections. Transient bullous dermolysis or other hereditary epidermolysis bullosa was considered as a diagnosis at first. Histopathologic examination showed subepidermal blister with many inflammatory cells including eosinophils. Direct immunofluorescence (DIF) revealed linear C3 and C1q deposits along the basement membrane zone. But, the results of immunoblotting and Enzyme-linked immunosorbent assay (ELISA) were negative. He was diagnosed as infantile BP. based on the clinical, histopathological and DIF findings. He has been treated with low dose of methylprednisolone for 1 month. Bullous lesions have disappeared from the trunk and feet but has not yet on hands. Although the common causes of neonatal blistering diseases are infections, clinician should consider possibility of autoimmune blistering disease such as infantile BP. To our knowledge, this is the first case of infantile BP in Korea. Herein we report a rare case of infantile BP with review of the literature.
A case of gingival pemphigus vulgaris
( Geon Wook Ryu ),( Sook Jung Yun ),( Seung-chul Lee ),( Young Ho Won ),( Jee-bum Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Pemphigus vulgaris(PV) is an autoimmune blistering disease affecting the mucous and skin. Typically, oral lesions appear before skin lesions, and in a majority of the cases only oral lesions are present. It is unusual for PV to present over the gingiva as a primary site of involvement. A 25-year-old man presented with multiple tender whitish erosive patches on gingiva for 7 months. In dental hospital, he had been treated with antibiotics and antifungal agents under the diagnosis of micro-organisms induced chronic gingivitis. But lesions were aggravated. Then, he referred to our department. A physical examination failed to reveal any skin lesion except for oral cavity. On the histopathologic examination of gingival erosive lesion, no specific pathologic findings were observed. However, indirect immunofluorescence test revealed deposition of IgG in intercellular space of the epidermal cells, and also immunoblotting assay detected autoantibodies against 130kD compatible to sera of PV. Based on these results, he was diagnosed as gingival PV. He has been treated with low dose of prednisolone (7.5mg/day). Erosive lesions of gingiva have been improved. Although the patient is young and has erosive lesions confined to gingiva, histological and immunological examinations should be undertaken to obtain definitive diagnosis. Herein we report a educational case of a young patient with gingival PV presenting with a 7 months history of painful gingiva.
A case of McCune-Albright syndrome
( Geon Wook Ryu ),( Jee Bum Lee ),( Seung Chul Lee ),( Young Ho Won ),( Sook Jung Yun ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
McCune-Albright syndrome (MAS) is a rare congenital disorder characterized by variety of endocrinologic dysfunction, cafe´-au-lait macules (CALM) and osseous fibrous dysplasia. The cause of MAS is GNAS gene mutation during embryogenesis, encoding the stimulatory G-protein alpha subunit and GNAS gene present in many type of tissue and mutation is distributed in mosaic patterns. Symptoms and presenting sign are dependent on the time mutation occurs. A 16-months-old female presented with brownish geographic diffuse patches on back, buttocks, pubic area, legs with irregular border since birth. She had no family history. On the histopathologic examination of brownish patch, CALM was diagnosed. Pelvic and spine X-ray reveals no deformity and polyostotic form of born yet. Ataxia and was not observed. Gene study through blood sampling and paraffin embedded tissue didn’t detect GNAS mutation. MAS should be evaluated to determine the extent of disease and intervened early in childhood to prevent irreversible disorders. Most of reported cases of MAS had CALM which distributes in developmental lines of Blaschko. Therefore dermatologist should consider large irregular cafe´-au-lait macules along Blaschko’s line as a clue to diagnose MAS. Herein, we report a typical case of McCune-Albright syndrome and review genetic mutation in this syndrome.
Clinical analysis of benign and malignant neoplasms of 366 patients in genital skin
( Geon Wook Ryu ),( Jee-bum Lee ),( Seong-jin Kim ),( Seung-chul Lee ),( Sook Jung Yun ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: There is little clinical analysis of benign and malignant neoplasms in genital skin in Korea. Objectives: This study was to investigate clinical features and proportion of neoplasms occurring in genital skin. Methods: We retrospectively reviewed all patients with tumors located on genital skin from 2010-2019. The patients were divided into 19 benign and 9 malignant tumor categories. Results: A total 366 were analyzed, including 178 (48.3%) patients with benign neoplasm and 188 (51.4%) with malignant neoplasm. The mean age was 58.2 years and 56.8% of patients were male. 191 patients (52.2%) showed no symptoms The most common benign neoplasm was bowenoid papulosis (n = 49), followed by seborrheic keratosis (n = 33), epidermal cyst & steatocystoma multiplex (n = 28), melanocytic nevus (n = 18), and angiokeratoma (n = 17). The most common malignant neoplasm was extramammary Paget’s disease (EMPD) (n = 68), followed by squamous cell carcinoma (n = 54), squamous cell carcinoma in situ (n = 28), basal cell carcinoma (n = 12) and malignant melanoma (n = 11). The most common benign and malignant neoplasm was epidermal cyst and squamous cell carcinoma in female, and bowenoid papulosis and EMPD in male, respectively. Each neoplasm showed specific predilection location. Conclusion: This study would be useful evidence and information in dermatological practice.
Ryu, Geon-Seek,Park, Soo-Hee,Kim, Eun-Sook,Choi, Byoung-Wook,Ryu, Shi-Yong,Lee, Bong-Ho The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.10
Two known farnesylacetone derivatives (1 and 2) were isolated from the Korean brown alga Sargassum sagamianum off Jeju Island, Korea. Compounds 1 and 2 were identified as (5E,10Z)-6, 10, 14-trimethylpentadeca-5, 10-dien-2, 12-dione and (5E,9E,13E)-6, 10,4-trimethylpentadeca-5,9,13-trien-2,12-dione, respectively, by comparison with the literature data. Compounds 1 and 2 showed moderate acetylcholinesterase and butyrylcholinesterase inhibitory activities with $IC_{50}$ values of 65.0∼48.0 and 34.0∼23.0 $\muM$, respectively.
류건욱 ( Geon Wook Ryu ),박형건 ( Hyung Keon Park ),이지범 ( Jee-bum Lee ),김성진 ( Seong-jin Kim ),이승철 ( Seung-chul Lee ),원영호 ( Young Ho Won ),윤숙정 ( Sook Jung Yun ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.7
Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a rare autosomal dominant genetic disorder that results in vascular malformation in the skin, mucous membrane, and other internal organs, such as the gastrointestinal tract, lung, liver, and brain. A 49-year-old man presented with purpuric punctate, spider-like telangiectasia on the face, hands, and fingers. He had episodes of recurrent nasal bleeding. The family members of the patient had similar events of recurrent nasal bleeding and cutaneous telangiectasia. Abdominal computed tomography revealed multiple arteriovenous malformations and cysts in the liver. Gastroendoscopy and colonoscopy showed angiodysplasia of the fundus of the stomach and mucous membrane of the colon. Histopathologic examination revealed dilated vessels lined with flat endothelial cells in the dermis. We report herein the case of HTT because it is rare and significant for differential diagnosis. (Korean J Dermatol 2020;58(7):476∼ 479)