Closed Walk Ferry Route Design for Wireless Sensor Networks

( Qiang Dou ),( Yong Wang ),( Wei Peng ),( Zhenghu Gong ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.10

Message ferry is a controllable mobile node with large capacity and rechargeable energy to collect information from the sensors to the sink in wireless sensor networks. In the existing works, route of the message ferry is often designed from the solutions of the Traveling Salesman Problem (TSP) and its variants. In such solutions, the ferry route is often a simple cycle, which starts from the sink, access all the sensors exactly once and moves back to the sink. In this paper, we consider a different case, where the ferry route is a closed walk that contains more than one simple cycle. This problem is defined as the Closed Walk Ferry Route Design (CWFRD) problem in this paper, which is an optimization problem aiming to minimize the average weighted delay. The CWFRD problem is proved to be NP-hard, and the Integer Linear Programming (ILP) formulation is given. Furthermore, a heuristic scheme, namely the Initialization-Split-Optimization (ISO) scheme is proposed to construct closed walk routes for the ferry. The experimental results show that the ISO algorithm proposed in this paper can effectively reduce the average weighted delay compared to the existing simple cycle based scheme.

CircZNF609 Aggravated Myocardial Ischemia Reperfusion Injury via Mediation of miR-214-3p/PTGS2 Axis

Wen-Qiang Tang,Feng-Rui Yang,Ke-Min Chen,Huan Yang,Yu Liu,Bo Dou 대한심장학회 2022 Korean Circulation Journal Vol.52 No.9

Background and Objectives: Circular RNAs were known to play vital role in myocardial ischemia reperfusion injury (MIRI), while the role of CircZNF609 in MIRI remains unclear. This study was aimed to investigate the function of CircZNF609 in MIRI. Methods: Hypoxia/reoxygenation (H/R) model was established to mimic MIRI in vitro. Quantitative polymerase chain reaction was performed to evaluate gene transcripts. Cellular localization of CircZNF609 and miR-214-3p were visualized by fluorescence in situ hybridization. Cell proliferation was determined by CCK-8. TUNEL assay and flow cytometry were applied to detect apoptosis. Lactate dehydrogenase was determined by commercial kit. ROS was detected by DCFH-DA probe. Direct interaction of indicated molecules was determined by RIP and dual luciferase assays. Western blot was used to quantify protein levels. In vivo model was established to further test the function of CircZNF609 in MIRI. Results: CircZNF609 was upregulated in H/R model. Inhibition of CircZNF609 alleviated H/R induced apoptosis, ROS generation, restored cell proliferation in cardiomyocytes and human umbilical vein endothelial cells. Mechanically, CircZNF609 directly sponged miR-214-3p to release PTGS2 expression. Functional rescue experiments showed that miR-214-3p/PTGS2 axis was involved in the function of circZNG609 in H/R model. Furthermore, data in mouse model revealed that knockdown of CircZNF609 significantly reduced the area of myocardial infarction and decreased myocardial cell apoptosis. Conclusions: CircZNF609 aggravated the progression of MIRI via targeting miR-214-3p/PTGS2 axis, which suggested CircZNF609 might act as a vital modulator in MIRI.

Stationary Distribution for the Mobilities in Catastrophe Rescue Scenario

( Yong Wang ),( Wei Peng ),( Qiang Dou ),( Zhenghu Gong ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.2

Mobility Model has drawn more and more attentions since its critical role in Mobile Wireless Networks performance evaluation. This paper analyzes the mobility patterns in the catastrophe rescue scenario, and proposes the Random Waypoint with Base Point mobility model to model these characteristics. We mathematically analyze the speed and spatial stationary distributions of the nodes and derive explicit expressions for the one dimensional case. In order to keep the stationary distribution through the entire simulation procedure, we provide strategies to initialize the speed, location and destination of the nodes at the beginning of the simulation. The simulation results verify the derivations and the proposed methods in this paper. This work gives a deep understanding of the properties of the Random Waypoint with Base Point mobility model and such understanding is necessary to avoid misinterpretation of the simulation results. The conclusions are of practical value for performance analysis of mobile wireless networks, especially for the catastrophe rescue scenario.

Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway

( Zhen Cao ),( Ce Dou ),( Jianmei Li ),( Xiangyu Tang ),( Junyu Xiang ),( Chunrong Zhao ),( Lingyu Zhu ),( Yun Bai ),( Qiang Xiang ),( Shiwu Dong ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.10

Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear. Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage. [BMB Reports 2016; 49(10): 548-553]

Synthesis of Uniform Polyaniline Nanosheets and Nanotubes: Dependence of Morphology on the pH

Yumei Zhang,Chengfu Dou,Wenping Wang,Qiang Wang,Ningchuan Feng 한국고분자학회 2016 Macromolecular Research Vol.24 No.8

Polyaniline (PANI) nanomaterials were synthesized by simplified template-free method with ammonium persulfate (APS) as an oxidant. The strong dependence of morphology of polyaniline on the initial pH of the reaction solution has been found. PANI morphology transformed from nanosheets to nanotubes with the decreasing initial pH from 6.70~6.50 to 5.30~5.00, and nanotubes changed further to irregular granules with the decreasing pH lower than 2.26. Polyaniline nanosheets were highly crystalline (2θ=6.2°) but poor in conductivity (5.7×10-5 S/cm) and electroactivity due to low doping level. Though polyaniline nanotubes were poorly crystalline, it had a relative high conductivity (3.4×10-2 S/cm) and maintained the electroactivity in acidic and neutral media which had potential applications in biomedical fields such as tissue engineering and biosensor.

Two New α-Pyrones and Other Components from the Cladodes of Opuntia dillenii

Ying Kun Qiu,Yan Yan Zhao,De Qiang Dou,Bi Xia Xu,Ke Liu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6

The aqueous ethanolic extract from the fresh cladodes of Opuntia dillenii HAW. was found to show anti-inflammatory activity. Two new α-pyrones, named opuntioside II (1) and opuntioside III (2), were isolated from the extract together with six known compounds. The structures of the new compounds were determined on the basis of chemical and physicochemical evidence.

Two New ${\alpha}$-Pyrones and Other Components from the Cladodes of Opuntia dillenii

Qiu, Ying-Kun,Zhao, Yan-Yan,Dou, De-Qiang,Xu, Bi-Xia,Liu, Ke 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6

The aqueous ethanolic extract from the fresh cladodes of Opuntia dillenii HAW. was found to show anti-inflammatory activity. Two new ${\alpha}$-pyrones, named opuntioside II (1) and opuntioside III (2), were isolated from the extract together with six known compounds. The structures of the new compounds were determined on the basis of chemical and physicochemical evidence.

Modification of coal tar-based porous carbon and analysis of its structure and electrochemical characteristics

Xu Xinyuan,Wu Peng,Zhou Chunru,Dou Qiang,Lv Yuting 한국탄소학회 2024 Carbon Letters Vol.34 No.1

Oxygen-rich porous carbon is of great interest for energy storage applications due to its improved local electronic structures compared with unmodified porous carbon. However, a tunable method for the preparation of oxygen-rich porous carbon with a special microstructure is still worth developing. Herein, a novel modification of porous carbon with different microstructures is facilely prepared via low-temperature solvothermal and KOH activation methods that employ the coal tar and eight substances, such as cellulose as carbon source and modifier, respectively. By testing the yield, surface group structure, lattice structures, morphology, thermal weight loss, and specific capacitance of carbonaceous mesophase, cellulose–hydrochloric acid is identified as the additive for the preparation of oxygen-rich coal tar-based porous carbon. The obtained porous carbon displays a specific surface area of up to 859.49 m2 g−1 and an average pore diameter of 2.39 nm. More importantly, the material delivers a high capacity of 275.95 F g−1 at 0.3 A g−1 and maintains a high capacitance of 220 F g−1 even at 10 A g−1. When in a neutral electrolyte, it can still retain a reversible capacity of 236.72 F g−1 at 0.3 A g−1 and 136.79 F g−1 at 10 A g−1. This work may provide insight into the design of carbon anode materials with high specific capacity.

Baimantuoluosides D-G, Four New Withanolide Glucosides from the Flower of Datura metel L.

Bing-you Yang,Yong-gang Xia,Qiu-hong Wang,De-qiang Dou,Hai-xue Kuang 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.8

In our search for bioactive anti-psoriasis compounds from the flower of Datura metel L, we isolated four new withanolide glucosides, baimantuoluosides D, E, F and G (1-4). The structures of the new compounds are (5α,6α,7β,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (1), (5α,6β,7α,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (2), (5α,6β,7α,12β,22R)-5,6,7,12,27-pentahydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (3), and (5α,6β,22R)-5,6,27-trihydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (4) on the basis of chemical and physicochemical evidence.

Antioxidant activity of ginseng cultivated under mountainous forest with different growing years

Hong-Yan Pan,Yang Qu,Jian-Kui Zhang,Ting-Guo Kang,De-Qiang Dou 고려인삼학회 2013 Journal of Ginseng Research Vol.37 No.3

Ginseng cultivated and grown naturally under mountainous forest is formally called “Lin-Xia-Shan-Shen” (LXSS) and grown in manual condition is called garden ginseng (GG) according to Chinese pharmacopoeia (2010 edition). Usually the growing condition of LXSS is similar to wild ginseng and mostly used in Chinese folks in ancient times. The antioxidant properties of LXSS with different growing years were evaluated by their inhibitions of thiobarbituric acid-reactive substance (TBA-RS) formation in liver homogenate and 2, 2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging activity comparing with those of GG. The inhibitions of different polar extracts (n-butanol and water) of LXSS and GG on TBA-RS formation were also evaluated. The results showed that the antioxidant effects of LXSS were higher than those of GG and the TBARS formation inhibition of LXSS with longer growing years were stronger than those with shorter growing years, while the DPPH-radical scavenging activity of LXSS did not show significant difference with the change of the growing year. The results indicated that the inhibitory effect of TBA-RS formation and the DPPH-radical scavenging of LXSS were correlated with the contents of ginsenosides. In adddition, the starch contents of LXSS and GG were determined by micro-amount method with spectrophotometer. It showed that the starch content in GG was higher than that of LXSS whose starch decreased gradually with the growing year.