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RISS 인기검색어
- 검색키워드
- 저자 : ( Mitsuhiro Denda ) (검색결과 8 건)
- 무료
- 기관 내 무료
- 유료
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Epidermal keratinocytes as the interface of body and environment
( Mitsuhiro Denda ) 한국피부장벽학회 2008 한국피부장벽학회지 Vol.10 No.2
Recently, a range of sensors that respond to physical or chemical environmental factors has been identified in the peripheral nervous system. In particular, TRP receptors, which respond to mechanical stress, osmotic pressure, temperature and chemical stimuli, are expressed in epidermal keratinocytes. Neurotransmitters and their receptors, which play a crucial role in information processing in the central nervous system, have also been found in keratinocytes. These results suggest that epidermal keratinocytes are equipped with similar sensing and information processing systems to those in the peripheral and central nervous systems. It had been long considered that only nerve C-terminals in the epidermis play a role in skin surface perception. However, we now propose a novel concept of the skin sensory system, i.e., first, keratinocytes recognize various environmental factors, and then the information is transferred to peripheral and whole body systems.
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Possible Role of Epidermal Keratinocytes in the Construction of Acupuncture Meridians
Mitsuhiro Denda,Moe Tsutsumi 사단법인약침학회 2014 Journal of Acupuncture & Meridian Studies Vol.7 No.2
Acupuncture meridians consist of a network of acupuncture points on the skin, stimula- tion of which is well established to have a variety of physiological effects. We have pre- viously demonstrated that epidermal keratinocytes contain multiple sensory systems for temperature, mechanical stimuli, electric potentials and other stimuli. These sensory systems generate changes in the calcium-ion concentration in the epidermis, so epidermal keratinocytes can generate spatially-localized electro-physiological patterns in the skin. We have previously demonstrated signaling between epidermal keratinocytes and peripheral nerve systems. Therefore, stimuli sensed by epidermal keratinocytes might be transferred to the unmyelinated nerve fibers that are known to exist in the epidermis and, thence, to the spinal cord and brain. We propose that epidermal kerati- nocytes form an information-gathering network in the skin and that this network plays a key role in whole-body homeostasis in response to the changing environment. We also hypothesize that this network corresponds to the acupuncture meridians. As supporting examples, we present some striking calcium propagation patterns observed in cultured human keratinocytes after adenosine-triphosphate (ATP) stimulation. These results sup- port the ideas that keratinocytes can generate spatially-restricted signaling patterns af- ter environmental stimulation and that the cultures might be in-vitro models of meridians as an information-gathering network in skin.
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Abstracts : Session 4 ; Homeostasis in Skin Barrier : Sensory Systems of Epidermal Keratinocytes
( Mitsuhiro Denda ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
It is well known that epidermal keratinocytes form a water-impermeable barrier at the skin surface. However, recent studies suggest that keratinocytes also have a variety of sensory systems for a wide range of environmental factors, including humidity, temperature, mechanical stress, electric potential, visible light, and sound. Epidermal keratinocytes express a series of thermo-activated receptors, called the transient receptor potential (TRP) family. The TRP proteins in epidermal keratinocytes may serve as sensors not only of environmental temperature, but also of humidity, mechanical stress and chemical stimuli. Activations of some TRP influence the barrier recovery process. Voltage-gated calcium channel is expressed in the epidermal keratinocytes and external electrical potential and materials that produce an electrical double layer influence barrier homeostasis. Photo-receptor proteins (rhodopsin and opsin) and energy-transfer proteins (transducin and phosphodiesterase 6), which are expressed in retina, are also expressed in keratinocytes and appear to influence epidermal barrier homeostasis. Moreover, epidermal barrier homeostasis is influenced by sound in the 10 to 30 kilohertz range. Interaction between keratinocytes and nerve fibers has also been reported. Moreover, a series of neurotransmitter receptors, which play key roles in information processing in the central nervous system, are expressed in keratinocytes. Thus, epidermal keratinocytes might be have both sensory and information-processing functions at the surface of the body. In this paper, I deal with these new aspects of epidermal keratinocytes and also discuss the hypothesis that epidermal keratinocytes serve as a functional interface between the body and the environment.
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Sensory Systems of Epidermal Keratinocytes
( Mitsuhiro Denda ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
It is well known that epidermal keratinocytes form a water-impermeable barrier at the skin surface. However, recent studies suggest that keratinocytes also have a variety of sensory systems for a wide range of environmental factors, including humidity, temperature, mechanical stress, electric potential, visible light, and sound. Epidermal keratinocytes express a series of thermo-activated receptors, called the transient receptor potential (TRP) family. The TRP proteins in epidermal keratinocytes may serve as sensors not only of environmental temperature, but also of humidity, mechanical stress and chemical stimuli. Activations of some TRP influence the barrier recovery process. Voltage-gated calcium channel is expressed in the epidermal keratinocytes and external electrical potential and materials that produce an electrical double layer influence barrier homeostasis. Photo-receptor proteins (rhodopsin and opsin) and energy-transfer proteins (transducin and phosphodiesterase 6), which are expressed in retina, are also expressed in keratinocytes and appear to influence epidermal barrier homeostasis. Moreover, epidermal barrier homeostasis is influenced by sound in the 10 to 30 kilohertz range. Interaction between keratinocytes and nerve fibers has also been reported. Moreover, a series of neurotransmitter receptors, which play key roles in information processing in the central nervous system, are expressed in keratinocytes. Thus, epidermal keratinocytes might be have both sensory and information-processing functions at the surface of the body. In this paper, I deal with these new aspects of epidermal keratinocytes and also discuss the hypothesis that epidermal keratinocytes serve as a functional interface between the body and the environment.
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