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- 저자 : ( Liang Changyu ) (검색결과 4 건)
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Hongsheng Liang,Xiangtong Zhang,Yibo Yin,Tie Lin,Dong Guan,Bowen Ma,Changyu Li,Yuehua Wang 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.1
The reorganization of brain structures after intracerebral hemorrhage (ICH) insult is crucial to functional outcome. Although the pattern of neuronal rewiring is well-docu-mented after ischemic stroke, the study of brain plasticity after ICH has been focusing on the enhancement of dendritic complexity. Here we hypothesized that functional restoration after ICH involves brain reorganization which may be favorably modulated by stem cell transplantation. In this study, bone marrow stromal cells (BMSCs) were transplanted into the perilesional sites of collagenase-induced ICH in adult rats one day after ICH injury. Forelimb functional recovery was monitored with modified limb placing and vibrissae-elicited forelimb placement tests. Anterograde and retrograde tracing were used to assess the reorganization of bilateral forelimb areas of the sen-sorimotor cortex. We found that in rats transplanted with BMSCs after ICH injury, axonal sprouting occurred in the contralateral caudal forelimb area of the cortex, and was significantly higher than in ICH rat models that received only the vehicle (P < 0.01). The number of positive neurons in the ipsilateral rostral forelimb area of the cortex of the BMSC group was 1.5- to 4.5-fold greater than in the vehicle group (P < 0.05). No difference was found between the BMSC and vehicle groups in hemispheric atrophy or labeled neurons in the ipsilateral caudal forelimb area (P = 0.193). Scores for improved functional behavior in the BMSC group were in accord with the results from histology. Neuronal plasticity of the denervated corticospinal tract at bilateral forelimb areas of the cortex in the collagenase-induced ICH rat models was significantly enhanced by BMSC transplantation. BMSC transplantation may facilitate functional recovery after ICH injury.
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Xu Jiang,Qing-Tian Su,Xu Han,Changyu Shao,Liang Chen 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.3
A new-type of orthotropic steel-concrete composite bridge deck system was developed, by casting the concrete overlay on the top of the orthotropic steel deck ribbed with T-shape steel members. To study its mechanical behavior (in terms of failure mode, load-deflection relationship, concrete crack initiation and propagation, strength, stiffness and so on), two new-type orthotropic steel-concrete composite bridge decks with different section dimensions were experimentally investigated and two reference decks (reinforced concrete deck and orthotropic steel deck) were also involved in the research for comparison. For the two new-type orthotropic steel-concrete composite decks, the average value of ultimate loads per width is 885.7kN, which is 2.35 and 1.61 times of that of the concrete and steel reference decks with almost the same section height. Experimental results proved that the composite deck can effectively control the crack initiation and propagation in the concrete and postpone the yielding of the steel bars and steel plates, due to the composite action between the concrete overlay and the underlying steel plate. Furthermore, the Finite Element (FE) model of the orthotropic steel-concrete composite deck was developed and validated by test results. A parametric study is conducted regarding to the stiffness of shear studs. With the validated FE model, stress distribution in the underlying steel plate and T-shape stiffeners and development of concrete cracking in the concrete overlay were characterized at different load levels.
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Research on the Formation Mechanism of Shear Zone in the Neogene Mudstone Landslide
( Xin Peng ),( Wang Tao ),( Liu Jiamei ),( Liang Changyu ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
The shear zone is the main control factor for the translational and rotational landslides.Different geometric forms of landslides were selected to analyze the process of structural change and the mechanical mechanisms of the bedding-parallel shear zone in Neogen period mudstones. The results show that there are weak layers, with high clay content, in translational landslides and rotational-translational landslides, such as those with bedding-parallel shear zone, while rotational landslides are composed of homogeneous material. The bedding-parallel shear zone can be divided into two parts: the main shear zone and the secondary shear zone. The main shear zone has an S-C fabric, the C plane has a strong scratch, and the S plane develops in high plastic mudstones. The clay contents of the main shear zone in a bedding-parallel sliding zone are greater than 50%, while the absolute content of minerals mixed with illite and montmorillonite exceeds to 20%. Creep and rapid slip are the main forms of structural deformation of the shear zone. Creep deformation mainly develops in the sliding zone with high amounts of clay particles; the microstructural adjustment of the slip zone shows no crack expansion and the clay minerals are a viscous flow. Progressive creep induced by water pressure and gravity will cause the acceleration of the creep and rapid sliding. Rapid sliding deformation, which is due to repeated shear, occurs along the fixed shear fracture-surface.
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