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Potential molecular mechanisms underlying the effect of arsenic on angiogenesis
Juan Zhang,Yue Zhang,Weiyan Wang,Zhiyi Zhang 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.11
Arsenic is a potent chemotherapeutic drug thatis applied as a treatment for cancer; it exerts its functionsthrough multiple pathways, including angiogenesis inhibition. As angiogenesis is a critical component of the progressionof many diseases, arsenic is a feasible treatmentoption for patients with other angiogenic diseases, includingrheumatoid arthritis and psoriasis, among others. However,arsenic is also a well-known carcinogen, demonstrating apro-angiogenesis effect. This review will focus on the dualeffects of arsenic on neovascularization and the relevantmechanisms underlying these effects, aiming to provide arational understanding of arsenic treatment. In particular, weexpect to provide a comprehensive overview of the currentknowledge of the mechanisms by which arsenic influencesangiogenesis.
HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-κB signal pathway
Zhang Juan,Chang Yuhan,Xia Haiyan,Xu Luwei,Wei Xiaowei 한국유전학회 2021 Genes & Genomics Vol.43 No.11
Background The potential role of HIST1H2BN in prostate cancer remains unclear. Objective To evaluate the carcinogenic role of HIST1H2BN in prostate cancer. Methods The expression of HIST1H2BN in prostate cancer was analyzed using TCGA database and clinical samples. The roles and mechanisms of HIST1H2BN were investigated in DU145 and PC3 cells. Results HIST1H2BN was signifcantly upregulated in prostate cancer. HIST1H2BN knockdown inhibited cell proliferation, migration and EMT phenotype in prostate cancer cells. Downregulating HIST1H2BN diminished the expression and binding activity of NF-κB p65, then infuenced the expression of MMP2 and MMP9. Conclusion This is the frst study to elaborate a HIST1H2BN-NF-κB-EMT regulatory axis in oncogenesis, indicating that HIST1H2BN might be potential therapeutic target for prostate cancer.
Juan Zhang,Huihui Kang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1
In this paper, we propose the generalized modified Hermitian and skew-Hermitian splitting (GMHSS)approach for computing the generalized Lyapunov equation. The GMHSS iteration is convergent to the uniquesolution of the generalized Lyapunov equation. Moreover, we discuss the convergence analysis of the GMHSSalgorithm. Further, the inexact version of the GMHSS (IGMHSS) method is formulated to improve the GMHSSmethod. Finally, some numerical experiments are carried out to demonstrate the effectiveness and competitivenessof the derived methods
Juan Xiao,Shuyi Li,Yong Sui,Xiaopeng Li,Qian Wu,Ruifen Zhang,Mingwei Zhang,Bijun Xie,Zhida Sun 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.4
The antioxidant activity of proanthocyanidins extracted from the lotus seedpods (LSPC) in vitro and ameliorative effects on memory impairment induced using scopolamine in mice were studied. 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging ability, oxygen radical absorbance capacity, and cellular antioxidant activity assays revealed a potent LSPC antioxidant activity. Y-maze and step-down avoidance testing showed that LSPC administration at 30, 60, and 90 mg/kg ameliorated memory impairment. LSPC improved glutathione peroxidase and superoxide dismutase activities, inhibited activities of monoamine oxidase-B, total nitric oxide synthase, neuronal nitric oxide synthase, and acetylcholinesterase, and had no influence on inducible nitric oxide synthase and nitric oxide levels in the brain. LSPC ameliorated scopolamineinduced memory impairment based on improvement of the antioxidant system and cholinergic activity, which may be associated with potent antioxidant ability.
Human Embryonic Stem Cells - a Potential Vaccine for Ovarian Cancer
Zhang, Zu-Juan,Chen, Xin-Hua,Chang, Xiao-Hong,Ye, Xue,Li, Yi,Cui, Heng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Objective: To investigate the therapeutic potential of human embryonic stem cells (hESCs) as a vaccine to induce an immune response and provide antitumor protection in a rat model. Methods: Cross-reactivity of antigens between hESCs and tumour cells was screened by immunohistochemistry. Fischer 344 rats were divided into 7 groups, with 6 rats in each, immunized with: Group 1, hESC; Group 2, pre-inactivated mitotic NuTu-19; Group 3 PBS; Group 4, hESC; Group 5, pre-inactivated mitotic NuTu-19; Group 6, PBS; Group 7, hESC only. At 1 (Groups 1-3) or 4 weeks (Groups 4-6) after the last vaccination, each rat was challenged intraperitoneally with NuTu-19. Tumor growth and animal survival were closely monitored. Rats immunized with H9 and NuTu-19 were tested by Western blot analysis of rat orbital venous blood for cytokines produced by Th1 and Th2 cells. Results: hESCs presented tumour antigens, markers, and genes related to tumour growth, metastasis, and signal pathway interactions. The vaccine administered to rats in Group 1 led to significant antitumor responses and enhanced tumor rejection in rats with intraperitoneal inoculation of NuTu-19 cells compared to control groups. In contrast, rats in Group 4 did not display any elevation of antitumour responses. Western blot analysis found cross-reactivity among antibodies generated between H9 and NuTu-19. However, the cytokines did not show significant differences, and no side effects were detected. Conclusion: hESC-based vaccination is a promising modality for immunotherapy of ovarian cancer.
Juan Zhang,Shifeng Li 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.7
In the paper, we apply a structure-preserving doubling algorithm to solve the continuous coupled algebraic Riccati equation (CCARE). Using the existence and uniqueness of the CCARE, we show that the iteration solution of the CCARE are positive semi-definite, symmetric, and unique. Further, we discuss the convergent analysis of the structure-preserving doubling algorithm. Moreover, we present two modified structure-preserving doubling algorithms. Finally, we offer corresponding numerical examples to illustrate the effectiveness of the derived numerical algorithms.
RPSA Gene Mutants Associated with Risk of Colorectal Cancer among the Chinese Population
Zhang, Shan-Chun,Jin, Wen,Liu, Hui,Jin, Ming-Juan,Chen, Ze-Xin,Ding, Zhe-Yuan,Zheng, Shuang-Shuang,Wang, Li-Juan,Yu, Yun-Xian,Chen, Kun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
The primary aim of this study was to evaluate the relationship of single nucleotide polymorphisms (SNPs) in ribosomal protein SA (RPSA) gene with colorectal cancer (CRC). A case-control study including 388 controls and 387 patients with CRC was conducted in a Chinese population. Information about socio-demography and living behavior factors was collected by a structured questionnaire. Three SNPs (rs2133579, rs2269349, rs7641291) in RPSA gene were genotyped by Illumina SnapShot method. Multiple logistic regression models were used for assessing the joint effects between tea consumption and SNPs on CRC. The subjects with rs2269349 CC genotype had a decreased risk for CRC (OR=0.60; 95%CI = 0.37-0.99), compared with TT/CT genotype after adjustment for covariates. A similar association of rs2269349 with rectal cancer was observed (OR=0.49; 95%CI=0.24-1.00). Further analyses indicated that this SNP could modify the protective effect of tea drinking on CRC. Among the subjects with rs2269349 TT/CT or rs2133579 AA/GA, there was a marginal significantly lower risk of CRC (OR and 95%CI: 0.63 and 0.39-1.01 for rs2269349; 0.64 and 0.40-1.02 for rs2133579) in tea-drinking subjects in comparison to non-tea-drinking subjects. Mutants in the RPSA gene might be associated with genetic susceptibility to CRC and influence the protective effect of tea consumption in the Chinese population.