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Lee, Hae Won,Lim, Mi-sun,Seong, Sook Jin,Lee, Joomi,Park, Jeonghyeon,Seo, Jeong Ju,Yun, Hwi-yeol,Baek, In-hwan,Kwon, Kwang-il,Yoon, Young-Ran Informa UK, Ltd. 2011 Expert opinion on drug metabolism & toxicology Vol.7 No.12
<P><B><I>Objectives:</I></B> An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compare the pharmacokinetics, pharmacodynamics and safety of triflusal EC with triflusal in healthy Korean male subjects to determine bioequivalence and non-inferiority for the purposes of marketing approval.</P><P><B><I>Methods:</I></B> A randomized, open-label, two-period, crossover study was conducted in 38 subjects. Either triflusal EC or triflusal was administered orally as a single 900 mg loading dose (day 1) followed by eight 600 mg/day maintenance doses on days 2 - 9, with a 13-day washout period. The plasma concentrations of 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), the predominant active metabolite of triflusal, were assessed after administration of the loading dose, using HPLC/MS/MS. The platelet aggregation response to arachidonic acid was determined using turbidimetric aggregometry. </P><P><B><I>Results:</I></B> The 90% CIs, for the geometric mean ratios of the log-transformed AUC<SUB>τ</SUB> and C<SUB>max</SUB> of HTB were seen to be within the predetermined range of 0.8 - 1.25. Triflusal EC was also shown to be non-inferior in its anti-aggregatory effect. No serious AEs were reported during this study.</P><P><B><I>Conclusions:</I></B> The pharmacokinetic and pharmacodynamic profiles of the two triflusal formulations met the requirements for bioequivalence and non-inferiority, respectively. Both formulations were well tolerated.</P>
중국조선족 서신에 나타난 ‘화류(花柳)’ 키워드의 함의
이주미(Lee Joomi) 한국문화융합학회 2021 문화와 융합 Vol.43 No.5
“Hwaryu( )”, found among the big data of Korean-Chinese correspondences, is small data but it is a meaningful keyword that can identify social and psychological sentiments of the period. Hwaryu was a word that referred to licensed quarters of the Japanese colonial period and ‘Hwaryu books’ mentioned in Korean Chinese correspondences for product requests are assumed to be gamuak textbooks used in in the past in gisaeng call-offices. Gisaeng call-offices were educational institutions that professionally and systematically taught traditional dance, folk songs, lyrics, and sijo. Before liberation, gisaengs were strongly viewed as prostitutes and harlots and they were often declared the principal offenders of moral corruption. From the early days of its establishment, China abolished the prostitution system along with polygamy, human trafficking, licensed and unlicensed prostitution, and gisaeng businesses. Amidst this, it strived to cultivate upcoming generations through entertainers who were formerly from gisaeng call-offices. Gisaengs became the principal transmitters of Korean traditional cultural art but they were also silenced because of their disreputable pasts. The extremely limitedly appearance of the keyword ‘hwaryu’ in correspondences of the Korean-Chinese is an effect of the socialistic remodeling pursued by the Chinese government and a sign of suppression.
이주미(Joomi Lee),최준섭(Junsub Choi),허환일(Hwanil Huh) 한국추진공학회 2022 한국추진공학회지 Vol.26 No.5
For the design of the shortened ED(Expansion Deflection) nozzle, a numerical study of ED nozzle was performed according to the length reduction methods. The first method is to reduce the extension length of the ED nozzle with 80% bell nozzle length by 10%, 20% and 30%. The second method is to shorten the extension length by increasing the nozzle throat angle. Due to the increase in the curvature of the contour as the length shortened, the decrease in the nozzle exit velocity between the ED nozzle with 80% bell nozzle length and the ED nozzle in the first method was reduced, and the thrust become similar. The ED nozzle of the second method increased the thrust by increasing the nozzle exit velocity compared to the ED nozzle with 80% bell nozzle length.