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( Woo-il Kim ),( Seong-min Park ),( Hyun-ju Lee ),( Hyun Ju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kiim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang Ko ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Drug-induced acneiform eruption is characterized by occurring on non-seborrheic location and spontaneous resolution after discontinuation of offending drug. Valproate, oxcarbazepine and topiramate are well-known antiepileptic drugs (AEDs) and various skin diseases including acneiform eruption have been reported as their adverse skin reaction. A 16-year-old boy presented with multiple erythematous monomorphic papules and pustules on trunk and both extremities. The lesion was first recognized several weeks after he was prescribed valproate to treat epilepsy 4 months ago. After one month, AED was changed to oxcarbazepine and then, eruption aggravated. His medication was additionally changed to topiramate, but the skin lesion became even worse. Skin biopsy performed from erythematous papule on trunk was consistent with acneiform eruption. In adverse skin reactions due to AED, AED with different chemical structure is usually recommended as an alternative therapy, since cross reactivity between aromatic AEDs (oxcarbazepine) and non-aromatic AEDs (valproate and topiramate) is extremely rare. This case could be informative for physicians to prescribe alternative drugs in case of hypersensitivity reaction to AEDs. They should keep in mind the possibility of cross reactivity among structurally different AEDs like aromatic and non-aromatic drugs.