http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Hanjoon Jo ) (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
( Yoomi Yeo ),( Ji Tak Rhu ),( Hanjoon Jo ),( Sung-ho Jang ),( Joonho Choi ),( Dong Woo Park ),( Tae-hyung Kim ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose Cognitive dysfunction and mood disorder are well- known comorbidities in COPD. However, the mechanism is not well under stood including change of brain function in COPD. We compared the hippocampal functional connectivity (FC) of COPD patients to normal controls. Method A total of 50 patients with COPD and 30 matched healthy controls were participated. We obtained clinical data including demographics, pulmonary functions, cognitive function and mood status. Both groups of patients underwent brain magnetic resonance imaging (MRI) procedures for acquisition of T1 anatomy and restingstate (rs) functional MRI (rsfMRI) data at 3T. All data were processed by FreeSurfer and AFNI packages. The FC maps of hippoca mpus (HP) were obtained for each individual subject, and a Welch’s t test were applied to get group difference. And, to find the relationship between various clinical scores and the degree of FC changes which showing significant group differences in C OPD patients, Pearson correlation coefficients (r) were calculated. Results Compared to normal control, COPD patients showed lower BMI, more comorbidity more cognitive dysfunction without difference in risk factors for stroke. In addition, COPD patients showed significantly decreased FC between HP and middle cingulate cortex (MCC) (pFWEcorrected < 0.05) compared to normal control. And, the degrees of HP-MCC FC were correlated with decreased forced expiratory volume in one second (FEV1) and higher Charlson Comorbidity Index at the significance level of p < 0.05. Even participant s in COPD group had more depression, higher smoking history and more dyspnea, those factors were not related with FC. Furt hermore, neither cognitive function nor mood scores were not correlated in HP-MCC FC. Conclusion The mechanism of decreased cognitive function or changed mood status in COPD patients is not fully discovered. However, our study showed that alterations in FC of hippocampal lesions might be related with the clinical course of COPD.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
