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Review : Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies
( Gi Su Oh ),( Hyung Jin Kim ),( Ai Hua Shen ),( Su Bin Lee ),( Dipendra Khadka ),( Arpana Pandit ),( Hong Seob So ) 대한전해질학회 2014 Electrolytes & Blood Pressure Vol.12 No.2
Cisplatin is one of the most widely used and highly effective drug for the treatment of various solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and nerves. Nephrotoxicity is the most well-known and clinically important toxicity. Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage, and inflammatory res-ponses, are closely associated with cisplatin-induced nephrotoxicity. Even though the establishment of cisplatin-induced nephrotoxicity can be alleviated by diuretics and pre-hydration of patients, the prevalence of cisplatin nephrotoxi- city is still high, occurring in approximately one-third of patients who have under- gone cisplatin therapy. Therefore it is imperative to develop treatments that will ameliorate cisplatin-nephrotoxicity. In this review, we discuss the mechanisms of cisplatin-induced renal toxicity and the new strategies for protecting the kidneys from the toxic effects without lowering the tumoricidal activity.