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RISS 인기검색어
- 검색키워드
- 저자 : ( Derrick Chen Wee Aw ) (검색결과 2 건)
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Kanokvalai Kulthanan,Supinda Chusakul,Marysia Tiongco Recto,Ma. Teresita Gabriel,Derrick Chen-Wee Aw,Narayanan Prepageran,Alson Wong,Jern Lin Leong,Henry Foong,Vo Thanh Quang,Torsten Zuberbier 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.4
Purpose: Across Hong Kong, Malaysia, the Philippines, Singapore, Thailand and Vietnam, (referred to as Asia) approximately 30-53 million individuals of the 151 million employed suffer from allergic rhinitis (AR) and urticaria. It is estimated that approximately 90% of patients with these allergic conditions are insufficiently treated, impacting the socioeconomic burden in terms of absence from work and decreased productivity. This study aims to estimate the socioeconomic burden of allergies in Asia and the cost savings that their adequate management can provide. Due to the limited availability of regional data, this study focused AR and urticaria in selected countries. Methods: Published literature, information from statistical bureaus, clinician surveys and extrapolation of selected data from the European Union were used to determine the socioeconomic costs of AR and urticaria. Results: Many patients in Asia suffer from perennial allergies and experience symptoms of AR and urticaria for up to 298 days per year. An estimate of the indirect costs of patients insufficiently treated for AR and urticaria amounts to USD 105.4 billion a year, which equates to USD 1,137-2,195 per patient due to absenteeism and presenteeism. Adherence to guideline-approved treatment can lead to estimated savings of up to USD 104 billion. Conclusions: The current study suggests that within Asia, the socioeconomic impact of AR and urticaria is similar to that seen in the European Union in spite of the lower wages in Asia. This is due to the mainly perennial allergens prevailing in Asia, whereas the sensitization patterns observed in the European Union are dominated by seasonal exposure to pollen. These results underline the need for governmental initiatives to increase public awareness on the prevention and treatment of these and other allergic diseases as well as greater research funding and large-scale studies to reduce their growing socioeconomic burden in coming years.
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( Tsen Fang Tsai ),( Yu Huei Huang ),( Joo-heung Lee ),( Seung-chul Lee ),( Tae-gyun Kim ),( Derrick Chen Wee Aw ),( Weibin Bao ),( Michelle Dee ),( Adriana Guana ),( Min-geol Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Although secukinumab demonstrated superior efficacy to ustekinumab in patients with moderate-tosevere plaque psoriasis at 16 and 52 weeks in the global CLEAR study, subgroup analysis among Asian population has not been investigated so far. Objectives: We aimed to describe the efficacy and safety of secukinumab versus ustekinumab over 52 weeks in Asian patients with moderate-to-severe plaque psoriasis in the CLEAR study. Methods: Patients with moderate-to-severe psoriasis received either secukinumab 300mg or ustekinumab 45 or 90mg. Logistic regression analysis of PASI 75, PASI 90 and PASI 100 at week 16 and 52 using nonresponder imputation was conducted, P<0.05 was considered significant. Results: Sixty-two Asian patients were included in the subanalysis (23 secukinumab vs 39 ustekinumab). Secukinumab was superior to ustekinumab in achieving PASI 90 response at week 16. Superior efficacy was also observed for secukinumab vs ustekinumab with respect to PASI 75 and PASI 90 at week 52. Secukinumab exhibited a favorable safety profile similar to ustekinumab in an Asian population, and also consistent with the main trial results. Conclusion: Secukinumab provided superior efficacy over ustekinumab in clearing skin of Asian patients with moderate-to-severe plaque psoriasis. These results are consistent with the core study results (NCT02074982).
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