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A New Fine-grain SMS Corpus and Its Corresponding Classifier Using Probabilistic Topic Model
( Jialin Ma ),( Yongjun Zhang ),( Zhijian Wang ),( Bolun Chen ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.2
Nowadays, SMS spam has been overflowing in many countries. In fact, the standards of filtering SMS spam are different from country to country. However, the current technologies and researches about SMS spam filtering all focus on dividing SMS message into two classes: legitimate and illegitimate. It does not conform to the actual situation and need. Furthermore, they are facing several difficulties, such as: (1) High quality and large-scale SMS spam corpus is very scarce, fine categorized SMS spam corpus is even none at all. This seriously handicaps the researchers’ studies. (2) The limited length of SMS messages lead to lack of enough features. These factors seriously degrade the performance of the traditional classifiers (such as SVM, K-NN, and Bayes). In this paper, we present a new fine categorized SMS spam corpus which is unique and the largest one as far as we know. In addition, we propose a classifier, which is based on the probability topic model. The classifier can alleviate feature sparse problem in the task of SMS spam filtering. Moreover, we compare the approach with three typical classifiers on the new SMS spam corpus. The experimental results show that the proposed approach is more effective for the task of SMS spam filtering.
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Gao Ran,Guo Wenjun,Fan Tianfei,Pang Junling,Hou Yangfeng,Feng Xiaohang,Li Bolun,Ge Weipeng,Fan Tianhui,Zhang Tiantian,Lu Jiakai,Jing He,Jin Mu,Yan Chen,Wang Jing 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Abdominal aortic aneurysm (AAA) is a permanent expansion of the abdominal aorta that has a high mortality but limited treatment options. Phosphodiesterase (PDE) 4 family members are cAMP-specific hydrolyzing enzymes and have four isoforms (PDE4A-PDE4D). Several pan-PDE4 inhibitors are used clinically. However, the regulation and function of PDE4 in AAA remain largely unknown. Herein, we showed that PDE4D expression is upregulated in human and angiotensin II-induced mouse AAA tissues using RT-PCR, western blotting, and immunohistochemical staining. Furthermore, smooth muscle cell (SMC)-specific Pde4d knockout mice showed significantly reduced vascular destabilization and AAA development in an experimental AAA model. The PDE4 inhibitor rolipram also suppressed vascular pathogenesis and AAA formation in mice. In addition, PDE4D deficiency inhibited caspase 3 cleavage and SMC apoptosis in vivo and in vitro, as shown by bulk RNA-seq, western blotting, flow cytometry and TUNEL staining. Mechanistic studies revealed that PDE4D promotes apoptosis by suppressing the activation of cAMP-activated protein kinase A (PKA) instead of the exchange protein directly activated by cAMP (Epac). Additionally, the phosphorylation of BCL2-antagonist of cell death (Bad) was reversed by PDE4D siRNA in vitro, which indicates that PDE4D regulates SMC apoptosis via the cAMP-PKA-pBad axis. Overall, these findings indicate that PDE4D upregulation in SMCs plays a causative role in AAA development and suggest that pharmacological inhibition of PDE4 may represent a potential therapeutic strategy.
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