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Shaban, Nadia Z,Salem, Halima H,Elsadany, Mohamed A,Ali, Bahy A,Hassona, Ehab M,Mogahed, Fayed AK Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: Infection with hepatitis B virus (HBV) is a major global public health problem, with a wide spectrum of clinical manifestations. Human cytosolic glutathione-S-transferases (GSTs) include several classes such as alpha (A), mu (M), pi (P), sigma (S), zeta (Z), omega (O) and theta (T). The present study aimed to investigate the role of GST omega genes (GSTO1 and GSTO2) in different groups of patients infected with HBV. Materials and Methods: HBV groups were classified according to clinical history, serological tests and histological analysis into normal carriers (N), acute (A), chronic (CH), cirrhosis (CI) and hepatocellular carcinoma (HCC) cases. The study focused on determination of the genotypes of GST omega genes (GSTO1 and GSTO2) and GST activity and liver function tests. Results: The results showed that GSTO1 (A/A) was decreased in N, A, CH, CI and HCC groups compared to the C-group, while, GSTO1 (C/A) and GSTO1(C/C) genotypes were increased significantly in N, A, CH, CI and HCC groups. GSTO2 (A/A) was decreased in all studied groups as compared to the C-group but GSTO2(A/G) and GSTO2(G/G) genotypes were increased significantly. In addition, GST activities, albumin and TP levels were decreased in all studied groups compared to the C-group, while the activities of transaminases were increased to differing degrees. Conclusions: The results indicate that GSTO genetic polymorphisms may be considered as biomarkers for determining and predicting the progression of HBV infection.
A Bioinformatics Approach for In Vivo Imaging of Endogenous MicroRNA Targets During Neurogenesis
( Mi Hee Jo ),( Chang Hyun Lee ),( Bahy A Ali ),( Saud A Alarifi ),( Abdulaziz A Al-khedhairy ),( Soon Hag Kim ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.3
MicroRNAs (miRNAs), a class of small non-coding RNAs, have been reported to be functionally involved with cellular metabolism and a variety of diseases. The importance of miRNA expression and functional targeting has recently become a focus of intense research. However, their endogenous molecular targets have not been clearly identified despite multiple attempts in prior studies using bioinformatics. Our bioinformatics strategy and in vitro validation by the PCR, identified 16 out of 337 miR124a-predicted targets and 5 out of 299 miR9*-predicted targets were significantly and directly down-regulated by each of the miRNAs during neurogenesis. In vitro and in vivo bioluminescent imaging system was used and successfully monitored the miR9*-mediated repression of SOX2 during neuronal differentiation of the P19 cells. The results of this study demonstrate that our bioinformatics approach offers a powerful and precise method for the identification of novel miR124a and miR9* endogenous targets during neuronal differentiation. This bioinformatics approach, using microarray data available from public DBs, provides a practical means for identifying the endogenous targets of other miRNAs.
Ko, Hae Young,Lee, Jonghwan,Lee, Yong Seung,Gu, Ha-Na,Ali, Bahy A.,Al-Khedhairy, Abdulaziz A.,Heo, Hyejung,Cho, Sujeong,Kim, Soonhag The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.11
<P>A dual fluorophore-based color-tunable molecular beacon visualized the microRNA-294 expression-dependent color change in cells.</P> <P>Graphic Abstract</P><P>A dual fluorophore-based color-tunable molecular beacon visualized the microRNA-294 expression-dependent color change in cells. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc08898k'> </P>
Sperm DNA-mediated reduction of nonspecific fluorescence during cellular imaging with quantum dots
Lee, Jonghwan,Choi, Kyung-ju,Choi, Youngsok,Ali, Bahy A.,Al-Khedhairy, Abdulaziz A.,Kim, Soonhag The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.58
<P>Salmon sperm DNA was used as a blocking agent to reduce background fluorescence signals from gelatin-coated cell culture dishes.</P> <P>Graphic Abstract</P><P>Salmon sperm DNA was used as a blocking agent to reduce background fluorescence signals from gelatin-coated cell culture dishes. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5cc04503g'> </P>
( Shams Tabrez Khan ),( Rizwan Wahab ),( Javed Ahmad ),( Abdulaziz A. Al-khedhairy ),( Maqsood A. Siddiqui ),( Quaiser Saquib ),( Bahy A. Ali ),( Javed Musarrat ) 한국화학공학회 2015 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.53 No.5
Envisaging the role of Co in theranautics and biomedicine it is immensely important to evaluate its antimicrobial activity. Hence in this study CoO thin nanosheets (CoO-TNs) were synthesized using wet chemical solution method at a very low refluxing temperature (90 oC) and short time (60 min). Scanning electron microscopy of the grown structure revealed microflowers (2~3 μm) composed of thin sheets petals (60~80 nm). The thickness of each individual grown sheet varies from 10~20 nm. Antimicrobial activities of CoO-TNs against two Gram positive bacteria (Micrococcus luteus, and Staphylococcus aureus), and two Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa) were determined. A 98% and 65% growth inhibition of M. luteus and S. aureus respectively, was observed with 500 μg/ml of CoO-TNs compared to 39 and 34% growth inhibition of E. coli and P. aeruginosa, respectively with the same concentration of CoO-TNs. Hence, synthesized CoO-TNs exhibited antimicrobial activity against Gram negative bacteria and an invariably higher activity against tested Gram positive bacteria. Therefore, synthesized CoO-TNs are less prone to microbial infections.