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RISS 인기검색어
- 검색키워드
- 저자 : ( Azadeh Ebrahim Habibi ) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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( Azadeh Ebrahim Habibi ),( Khosro Khajeh ),( Mohsen Nemat Gorgani ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.6
The lysine residues of Bacillus licheniformis α-amylase (BLA) were chemically modified using citraconic anhydride or succinic anhydride. Modification caused fundamental changes in the enzymes specificity, as indicated by a dramatic increase in maltosidase and a reduction in amylase activity. These changes in substrate specificity were found to coincide with a change in the cleavage pattern of the substrates and with a conversion of the native endo- form of the enzyme to a modified exo- form. Progressive increases in the productions of p-nitrophenol or glucose, when para nitrophenyl-maltoheptaoside or soluble starch, respectively, was used as substrate, were observed upon modification. The described changes were affected by the size of incorporated modified reagent: citraconic anhydride was more effective than succinic anhydride. Reasons for the observed changes are discussed and reasons for the effectivenesses of chemical modifications for tailoring enzyme specificities are suggested.
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Habibi, Azadeh Ebrahim,Khajeh, Khosro,Nemat-Gorgani, Mohsen Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.6
The lysine residues of Bacillus licheniformis $\alpha$-amylase (BLA) were chemically modified using citraconic anhydride or succinic anhydride. Modification caused fundamental changes in the enzymes specificity, as indicated by a dramatic increase in maltosidase and a reduction in amylase activity. These changes in substrate specificity were found to coincide with a change in the cleavage pattern of the substrates and with a conversion of the native endo- form of the enzyme to a modified exo- form. Progressive increases in the productions of $\rho$-nitrophenol or glucose, when para nitrophenyl-maltoheptaoside or soluble starch, respectively, was used as substrate, were observed upon modification. The described changes were affected by the size of incorporated modified reagent: citraconic anhydride was more effective than succinic anhydride. Reasons for the observed changes are discussed and reasons for the effectivenesses of chemical modifications for tailoring enzyme specificities are suggested.
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Targeting Acetate Kinase: Inhibitors as Potential Bacteriostatics
( Saeme Asgari ),( Parvin Shariati ),( Azadeh Ebrahim Habibi ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.11
Despite the importance of acetate kinase in the metabolism of bacteria, limited structural studies have been carried out on this enzyme. In this study, a three-dimensional structure of the Escherichia coli acetate kinase was constructed by use of molecular modeling methods. In the next stage, by considering the structure of the catalytic intermediate, trifluoroethanol (TFE) and trifluoroethyl butyrate were proposed as potential inhibitors of the enzyme. The putative binding mode of these compounds was studied with the use of a docking program, which revealed that they can fit well into the enzyme. To study the role of these potential enzyme inhibitors in the metabolic pathway of E. coli, their effects on the growth of this bacterium were studied. The results showed that growth was considerably reduced in the presence of these inhibitors. Changes in the profile of the metabolic products were studied by proton nuclear magnetic resonance spectroscopy. Remarkable changes were observed in the quantity of acetate, but other products were less altered. In this study, inhibition of growth by the two inhibitors as reflected by a change in the metabolism of E. coli suggests the potential use of these compounds (particularly TFE) as bacteriostatic agents.
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Indole-based derivatives effect on rats with polycystic ovary syndrome
Parichehreh Yaghmaei,Babak Dehestani,Samira Ghorbani,Farzaneh Abbasi,Azadeh Ebrahim‑Habibi 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.5
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, for which efficient therapies are needed. In this study, PCOS was induced in rats by intraperitoneal administration of testosterone propionate (0.2 mg/kg). Indole-based compounds 5-hydroxy indole-2-carboxylic acid, N-acetyl-tryptophan, Tryptamine, l-Tryptophan and Tryptophol were administered for 8 weeks in the PCOS model, after what histopathological assessment of ovaries was performed. The number of primary follicles, corpus luteum, growing follicles and graafian follicles increased and the number and diameter of ovarian cysts decreased in all treated rats in comparison with untreated group. In conclusion, l-Tryptophan and Tryptophol were most efficient as potential therapeutic molecules.
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