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      • Bullous fixed drug eruption due to topiramate

        ( Su-hyuk Yim ),( Jin-hyup Lee ),( Kyung-duck Park ),( Chong Won ),( Choi Young Lee ),( 3young-joon Seo ),( Jeung-hoon Lee ),( Dong-kyun Hong ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

        Fixed drug eruption is a well-demarcated, erythematous, patchy or blistering skin lesion that occurs repeatedly at the same site. The lesion occurs when exposed to the causative agent, leaving hyperpigmentation after healing. A 32-year-old young woman visited our clinic with a wrinkled blister-like lesion on her wrist 3-4 days earlier. She had a similar lesion occurred in the same site and the scar was left. She had no specific illness but was taking acetaminophen, alginic acid, caffeine and topiramate for the purpose of weight loss. Based on the fact that the lesion recurred mainly in similar locations, patch tests were performed on the normal skin of the patient for the four suspected drugs. Patch test showed positive finding for topiramate. In the case of a fixed drug eruption showing a blister lesion observed on the wrist, it may be necessary to distinguish between friction blister and other bullous diseases. In recent years, the use of weight-loss drugs has been increasing, so it is necessary to recognize the drug eruption of these drugs. Therefore, we report a rare case of bullous fixed drug eruption caused by topiramate for the weight loss.

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