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Vaishali Vajpayee,Young Ho Song,Jeong Soo Ahn,지기환 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.8
One-pot homo- and cross-coupling reactions of arenediazonium tosylate salts bearing a halogen group have been exploited for the synthesis of biaryls and polyaryls under mild conditions. Pd(OAc)_2 has proven to be an efficient catalyst for the successful dual transformation of diazonium salts into p-quaterphenyl (3).
Smart Bioreso rbable Polymers for Pharmaceuticals and Medical Devices
Vaishali Tawde,Sundeep Chaurasia,Saurabh Gupta,Rohan Rastogi,Ajay Kumar Dantuluri,Walter Liu,Sean Mcmahon,Dong-Won Seo 대한약학회 2022 약학회지 Vol.66 No.1
Smart bioresorbable polymers play a crucial role in pharmaceutical drug delivery and medical device applications. Among several bioresorbable polymers, poly lactic-co-glycolic acid and poly lactic acid are two common synthetic polymers used for various applications. Owing to their stimuli-sensitive behavior, they are called ‘smart polymers.’ Numerous commercial applications have demonstrated the effective use of bioresorbable polymer-based drug delivery systems for the treatment and diagnosis of several diseases and disorders. This review provides an overview of bioresorbable polymers as well as the associated commercial technologies and applications in the United States Food and Drug Administration-approved products and in drug delivery and medical devices.
Vaishali Murade,Keshav Deshmukh,Rupali Murade,Dipak Raut,Machindra Chavan,Dinesh Hase 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.4
The antinociceptive effect of chloroform extract (RCLC), semi-purified fraction (RC2) and isolated pentacyclic triterpenoid β-amyrin (BA) from the leaves of Ricinus communis in acetic acid-induced abdominal writhing, formalin-induced paw licking and hot-plate test was conducted in mice. The GC-MS study revealed that the RC2 showed the dominance of diterpenes, triterpenes, fatty acids, sterol and higher alkanes. No obvious behavioral changes, allergic reactions and mortality were observed in acute toxicity studies. Acute administration of the diazepam (1 mg/kg), RC2 (50 mg/kg) and BA (10 mg/kg) displayed mild sedation in open field test while RCLC (100 mg/kg) showed potent sedative properties. No motor incoordination and neurotoxicity was observed in rota-rod test. RCLC (100 mg/kg), RC2 (25 and 50 mg/kg) and BA (5 and 10 mg/kg) significantly inhibited the number of abdominal writhing induced by acetic acid and formalin-induced paw licking response. The central and peripheral antinociceptive effects for RCLC and RC2 in hot-plate were comparable to morphine. The administration of naloxone reversed the antinociceptive effect of morphine, RCLC and RC2 indicating the involvement of opioid receptors while BA principally showed peripheral antinociceptive effects which may be modulated via peripheral opioid receptors or protein kinase.
Vajpayee, Vaishali,Kim, Hyunuk,Mishra, Anurag,Mukherjee, Partha Sarathi,Stang, Peter J.,Lee, Min Hyung,Kim, Hwan Kyu,Chi, Ki-Whan Royal Society of Chemistry 2011 Dalton Transactions Vol.40 No.13
<P>Self-assemblies between a linear Pt-based donor and ferrocene- chelated metallic acceptors produced novel heterometallic squares 4 and 5, which show fluorescence quenching upon the addition of nitro-aromatics.</P> <P>Graphic Abstract</P><P>Heterometallic discrete squares were self-assembled by the combination of metal-based donor with <I>cis</I>-blocked metal acceptors and these squares showed selective sensing for nitroaromatics with high sensitivity for picric acid. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0dt01481h'> </P>
Tarte, Vaishali N,Seok, Hye-Yeon,Woo, Dong-Hyuk,Le, Dinh Huan,Tran, Huong T,Baik, Ji-Won,Kang, In Soon,Lee, Sun-Young,Chung, Taijoon,Moon, Yong-Hwan Springer 2015 Plant cell reports Vol.34 No.7
<P>AtSFT12, an Arabidopsis Qc-SNARE protein, is localized to Golgi organelles and is involved in salt and osmotic stress responses via accumulation of Na (+) in vacuoles. To reduce the detrimental effects of environmental stresses, plants have evolved many defense mechanisms. Here, we identified an Arabidopsis Qc-SNARE gene, AtSFT12, involved in salt and osmotic stress responses using an activation-tagging method. Both activation-tagged plants and overexpressing transgenic plants (OXs) of the AtSFT12 gene were tolerant to high concentrations of NaCl, LiCl, and mannitol, whereas loss-of-function mutants were sensitive to NaCl, LiCl, and mannitol. AtSFT12 transcription increased under NaCl, ABA, cold, and mannitol stresses but not MV treatment. GFP-fusion AtSFT12 protein was juxtaposed with Golgi marker, implying that its function is associated with Golgi-mediated transport. Quantitative measurement of Na(+) using induced coupled plasma atomic emission spectroscopy revealed that AtSFT12 OXs accumulated significantly more Na(+) than WT plants. In addition, Na(+)-dependent fluorescence analysis of Sodium Green showed comparatively higher Na(+) accumulation in vacuoles of AtSFT12 OX cells than in those of WT plant cells after salt treatments. Taken together, our findings suggest that AtSTF12, a Golgi Qc-SNARE protein, plays an important role in salt and osmotic stress responses and functions in the salt stress response via sequestration of Na(+) in vacuoles.</P>