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        Synthesis and Evaluation of Antimicrobial Activity of 1, 3, 4-Thiadiazole Analogues for Potential Scaffold

        Sahu, Sagar,Sahu, Tanesh,Kalyani, Gunjan,Gidwani, Bina KOREAN PHARMACOPUNCTURE INSTITUTE 2021 Journal of pharmacopuncture Vol.24 No.1

        Objectives: Pathogenic microbes are causal agents for various types of severe and even lethal infectious diseases. Despite of development in medication, bacterial and fungal infections still persist to be a vital problem in health care. Bacteria and several fungal species have shown resistance to antibiotics used in treatment to current medications. Therefore, it is a considerable field of interest in the design and development of novel compounds with antimicrobial activity. Methods: The compounds bearing a heterocyclic ring play an imperative role among other organic compounds with pharmacological activity used as drugs in human for control and cure of various infections. Thiadiazoles containing nitrogen-sulfur atom as part of their cyclic structure which shown wide-ranging application as structural units of biologically active molecules and are very useful intermediates in Medicinal Chemistry. Results: The effectiveness of the thiadiazole nucleus was established by the drugs currently used for the treatment of various infections. 1,3,4-Thiadiazoles and some of their derivatives are widely studied because of their broad spectrum of pharmacological activities. Conclusion: In the present work, a series of 1,3,4-Thiadiazole derivatives were synthesized by cyclization of a group of various benzaldehyde with thiosemicarbazide in the presence of various reagent like FeCl3, HCHO by losing a molecule of water. These derivatives were found to possess prominent antimicrobial activity.

      • FPGA Based Low Power DES Algorithm Design and Implementation using HTML Technology

        Vandana Thind,Bishwajeet Pandey,Kartik Kalia,D M Akbar Hussain,Teerath Das,Tanesh Kumar 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.6

        In this particular work, we have done power analysis of DES algorithm implemented on 28nm FPGA using HTML (H-HSUL, T-TTL, M-MOBILE_DDR, L-LVCMOS) technology. In this research, we have used high performance software Xilinx ISE where we have selected four different IO Standards i.e. MOBILE_DDR, HSUL_12, LVTTL and LVCMOS (LVCMOS_15, LVCMOS_18, LVCMOS_25 and LVCMOS_33). We have done power analysis of on-chip power like clock power, signals power, IO power, leakage power and supply power. We notified our analysis at five different voltages like 0.5V, 0.8V, 1.0V, 1.2V and 1.5V.

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