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Junbo Zhang,Shuanghong Yin,Fei Guo,Ren Meng,Chuangfu Chen,Hui Zhang,Zhi-qiang Li,Qiang Fu,Huijun Shi,Shengwei Hu,Wei Ni,Tiansen Li,Ke Zhang 한국미생물학회 2014 The journal of microbiology Vol.52 No.8
Brucellosis is a globally distributed zoonotic disease that causes animal and human diseases. However, the current Brucella abortus vaccines (S19 and RB51) are deficient; they can cause abortion in pregnant animals. Moreover, when the vaccine S19 is used, tests cannot differentiate natural from vaccinated infection. Therefore, a safer and more potent vaccine is needed. A Brucella abortus 2308 ery promoter mutant (Δery) was constructed to overcome these drawbacks. The growth of the Δery mutant was significantly attenuated in macrophages and mice and induced high protective immunity in mice. Moreover, Δery induced an anti-Brucellaspecific IgG (immunoglobulin G) response and stimulated the expression of interferon-gamma (INF-γ) and interleukin-4 (IL-4). Furthermore, the expression of EryA antigen allowed for the serological differentiation between natural and vaccinated infection in mice. These results indicate that the Δery mutant is a potential attenuated live vaccine candidate against virulent Brucella abortus 2308 (S2308) infection.
Jian Xue,Zefei Jiang,Fan Qi,Shuanghong Lv,Shaohua Zhang,Tao Wang,Xiaozhong Zhang 한국유방암학회 2014 Journal of breast cancer Vol.17 No.4
Purpose: In the present study, we investigated the incidence ofcardiotoxicity within 5 years of trastuzumab treatment and evaluatedpotential risk factors in clinical practice. Methods: The studycohort included 415 patients diagnosed with early breast cancer(EBC). Cardiotoxicity incidence was evaluated in patients receivingtrastuzumab and those who did not. Multivariate Cox proportionalhazards regression models were used to estimate hazardratios and 95% confidence intervals of potential risk factorsfor trastuzumab-related cardiotoxicity after appropriate adjustments. Results: Incidence of cardiotoxicity in patients treatedwith trastuzumab was significantly higher than that in controls(23.7% vs. 10.8%, p<0.001). This result was adjusted for factorsthat might increase the risk of cardiotoxicity, such as historyof coronary artery diseases or the use of anthracyclines for morethan four cycles. Conclusion: Our findings indicated that treatmentwith trastuzumab was strongly associated with cardiotoxicityin EBC patients.
Xiao Huang,Xi Zheng,Caixia Yi,Shuanghong Yin 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.5
Amphipathic polymer coated magnetic nanoparticles which are loaded with docetaxel as photoresponsive multifunctional drug delivery systems for safer cancer therapy have been fabricated. Such kind of drug delivery system not only possesses favorable magnetic response property, but also could realize docetaxel-release and EGF-adsorption simultaneously simulated by UV and dark control, which can significantly boost the effectiveness of chemotherapy.