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Does Inhaled Peppermint Essential Oil Affect Blood Pressure?
Park, Sah-Hoon,Kim, Kun-Hee,Park, Jong-Seong The Basic Science Institute Chosun University 2021 조선자연과학논문집 Vol.14 No.3
By far, studies on the effect of oral administration of peppermint essential oil on blood pressure are not consistent, increasing or decreasing. And the effect of inhalation of peppermint essential oil on blood pressure was not reported. This study was designed to clarify the effect of peppermint essential oil inhalation on the blood pressure and autonomic nervous system. Blood pressure and heart rate variability (HRV) as an indicator of autonomic nervous system activity were measured. The systolic and diastolic blood pressure was not changed significantly by inhalation of peppermint essential oil. Standard deviation of normal to normal (SDNN), a parameter of total activity of autonomic nervous system also was not changed significantly. High frequency (HF) power level, an indicator of parasympathetic nervous system activity was not changed by peppermint. These results indicate that action mechanism of peppermint essential oil on blood pressure is different by the method of administration, oral or inhalation.
Functional Changes of Spinal Sensory Neurons Following Gray Matter Degeneration
Park, Sah-Hoon,Park, Jong-Seong,Jeong, Han-Seong The Korean Physiological Society 1996 대한생리학회지 Vol.30 No.2
Excitatory amino acids (EAA) are thought to play an important role in producing cell death associated with ischemic and traumatic spinal cord injury. The present study was carried out to determine if the response characteristics of spinal sensory neurons in segments adjacent to degeneration sites induced by EAA are altered following these morphological changes. Intraspinal injections of quisqualic acid (QA) produced neuronal degeneration and spinal cavitation of gray matter. The severity of lesions was significantly attenuated by pretreatment with a non-NMDA antagonist NBQX. In extracellular single unit recordings, dorsal horn neurons in QA injected animal showed the increased mechanosensitivity, which included a shift to the left in the stimulus-response relationship, an increased background activity and an increase in the duration of after-discharge responses. Neuronal responses, especially the C-fiber response, to suprathreshold electrical stimulation of sciatic nerve also increased in most cases. These results suggest that altered functional states of neurons may be responsible for sensory abnormalities, e.g. allodynia and hyperalgesia, associated with syringomyolia and spinal cord injury.
Functional Characteristics of Lumbar Spinal Neurons Projecting to Midbrain Area in Rats
Park, Sah-Hoon,Kim, Geon The Korean Physiological Society 1994 대한생리학회지 Vol.28 No.2
The present study was carried out to characterize the functional properties of spinomesencephalic tract (SMT) neurons in the lumbar spinal cord of urethane anesthetized rats. Extracellular single unit recordings were made from neurons antidromically activated by stimulation of the midbrain area, including the deep layers of superior colliculus, periaqueductal gray and midbrain reticular formation. Recording sites were located in laminae I-VII of spinal cord segments of L2-L5. Receptive field properties and responses to calibrated mechanical stimulation were studied in 78 SMT cells. Mean conduction velocity of SMT neurons was $19.1{\pm}1.04\;m/sec$. SMT units were classified according to their response profiles into four groups: wide dynamic range (58%), deep/tap (23%), high threshold (9%) and low threshold (3%). A simple excitatory receptive field was found for most SMT neurons recorded in superficial dorsal horn (SDH). Large complex inhibitory and/or excitatory receptive fields were found for cells in lateral reticulated area which usually showed long after-discharge. Most of SMT cells received inputs from $A{\delta}$ and C afferent fiber types. These results suggest that sensory neurons in the rat SMT may have different functional roles according to their location in the spinal cord in integrating and processing sensory inputs including noxious mechanical stimuli.
Effects of Chamaecyparis Obtusa Essential Oil on the Autonomic Nervous System
Park, Sah-Hoon,Jeong, Han-Seong,Jang, Sujeong,Kim, Seong Jin,Park, Jong-Seong The Basic Science Institute Chosun University 2019 조선자연과학논문집 Vol.12 No.3
The purpose of this study is to explore the effects of Chamaecyparis obtusa essential oil on the activity of autonomic nervous system. Heart rate variability (HRV), as an indicator of autonomic nervous system activity and blood pressure were measured before and after inhalation of Chamaecyparis obtusa essential oil. The systolic blood pressure was decreased by inhalation of Chamaecyparis obtusa essential oil (p<0.05). The diastolic blood pressure was not changed significantly by Chamaecyparis obtusa. High frequency (HF) power level was not changed but High frequency/Low frequency (HF/LF) ratio was decreased by Chamaecyparis obtusa essential oil (p<0.05), meaning that parasympathetic nervous system activity was not affected but sympathetic nervous system activity was decreased. These results indicate that Chamaecyparis obtusa essential oil has a modulatory effect on the autonomic nervous system activity.
Responses of Inferior Olive Neurons to Stimulation of Semicircular Canals
Park, Sah-Hoon,Park, Jong-Seong,Lee, Min-Su,Shin, Jung-Woo The Korean Society of Pharmacology 2002 The Korean Journal of Physiology & Pharmacology Vol.6 No.4
In spite of abundant anatomical evidences for the fiber connection between vestibular nuclei and inferior olivary (IO) complex, the transmission of vestibular information through the vestibulo- olivo-cerebellar climbing fiber pathway has not been physiologically established. The aims of the present study were to investigate whether there are IO neurons specifically responding to horizontal rotation and also in which subregions of IO complex these vestibularly-activated neurons are located. The extracellular recording was made in 68 IO neurons and responses of 46 vestibularly-activated cells were analyzed. Most of the vestibularly-activated IO neurons responded to signals of vertical rotation (roll), while a small number (13/46) of recorded cells were activated by horizontal canal signal (yaw). Regardless of yaw-sensitive or roll-sensitive, vestibular IO neurons were excited, when the animal was rotated to the side contralateral to the recording side. The gain and excitation phase were very similar to otolithic or vertical-canal responses. Histologic identification of recording sites showed that most of vestibular IO neurons were located in ${\beta}$ subnucleus. Electrical stimulation of a HSC evoked an inhibitory effect on the excitability of the ipsilateral IO neurons. These results suggest that IO neurons mainly in the ${\beta}$ subnucleus receive vestibular signals from semicircular canals and otolithic organs, encode them, and transmit vestibular information to the cerebellum.
Park, Sah-Hoon,Park, Jong-Seong,Park, Jin-Soon The Korean Society of Pharmacology 2003 The Korean Journal of Physiology & Pharmacology Vol.7 No.4
In the present study, the vestibularly evoked activity of inferior olive (IO) neurons was examined to investigate the vertical vestibular information transmitted through the vestibulo-olivo-cerebellar climbing fiber pathway. The extracellular recording was made in 74 neurons of the IO of cats, while animals were sinusoidally rotated. Most of vestibularly activated IO neurons responded to the vertical rotation (roll) test and were found in or near the ${\beta}$ subnuclei $(IO{\beta})$. The vestibular IO neurons were activated, when the animal was rotated to the side contralateral to the recording site. In contrast to the observation that the gain of responses of yaw sensitive cells (YSC) was not changed by the rotation frequency, that of the roll-sensitive cells (RSC) decreased as the rotation frequency was increased. Regardless of RSC or HSC, IO neurons showed the tendency of phase-lag in their responses. The alternating excitatory and inhibitory phases of responses of RSC were dependent on the direction of head orientation, the characteristics of which are the null response plane (NRP) and the optimal response plane (ORP). The analysis based on the NRP of RSC showed that vestibular inputs from the ipsilateral anterior semicircular canal induced the NRP of the RSC response at about 45 degree counterclockwise to the longitudinal axis of the animal, and that those inputs were distributed to RSC in the rostral part of $IO{\beta}$. On the other hand, those from the posterior semicircular canal were related with the NRP at about 45 degree clockwise and with the caudal part of the $IO{\beta}$. These results suggest that IO neurons receive and encode the vestibular information, the priority of which seems to be the vertical component of the body movement rather than the horizontal ones.