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Effect of file size in measuring electronic working length of teeth with open apex
Ryeon Jin,Ju-Hee Jeong,A-Ra Cho,Hyoung-Hoon Jo 조선대학교 치의학연구원 2022 Oral Biology Research (Oral Biol Res) Vol.46 No.1
This study aimed to evaluate the effect of file size in measuring the electronic working length of teeth with open apex. Twenty teeth were prepared to make the open apex models. A bur was used to cut a 2-mm apical end; the point where #10K file’s tip was reflected on the cut root surface was set to the actual root canal length (AL). A divergent open apex was prepared by retrograde apical preparation. The teeth that were covered with a gauze soaked with saline were inserted in a plastic mold, and an electronic apex locator was connected with it. In each tooth, #10, #20, #30, #40, #50, #60, #70, and #80 files were inserted into the root canal, and the electronic working length (EL) was measured at the “Apex” signal. Then, the mean difference (ΔL) between the AL and EL was evaluated for each file size. EL measurements with all file sizes were short of the apical foramen, and there was a significant difference when the file size increased from #10 to #20 and #40 to #50. Within this study’s limitations, the file size showed an impact in measuring the teeth’s EL with open apex. When the size of the apical foramen is 1.14 mm, it is more accurate to use a file of #50 size or larger when measuring the working length with an electronic apex locator.
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Effect of Slit/Robo signaling on regeneration in lung emphysema
Park Jin-Soo,Cho RyeonJin,Kang Eun-Young,Oh Yeon-Mok 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Emphysema, a pathological component of chronic obstructive pulmonary disease, causes irreversible damage to the lung. Previous studies have shown that Slit plays essential roles in cell proliferation, angiogenesis, and organ development. In this study, we evaluated the effect of Slit2 on the proliferation and migration of mouse lung epithelial cells and its role in regeneration in an emphysema lung mouse model. Here, we have shown that Slit2/Robo signaling contributes to the regeneration of lungs damaged by emphysema. Mouse epithelial lung cells treated with Slit2 exhibited increased proliferation and migration in vitro. Our results also showed that Slit2 administration improved alveolar regeneration in the emphysema mouse model in vivo. Furthermore, Slit2/Robo signaling increased the phosphorylation of ERK and Akt, which was mediated by Ras activity. These Slit2-mediated cellular signaling processes may be involved in the proliferation and migration of mouse lung epithelial cells and are also associated with the potential mechanism of lung regeneration. Our findings suggest that Slit2 administration may be beneficial for alveolar regeneration in lungs damaged by emphysema.
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Park, Jin-Soo,Kim, Hyun Kuk,Kang, Eun-Young,Cho, RyeonJin,Oh, Yeon-Mok The Korean Academy of Tuberculosis and Respiratory 2019 Tuberculosis and Respiratory Diseases Vol.82 No.2
Background: A recent study reported that mesenchymal stem cells possess potential cellular therapeutic properties for treating patients with chronic obstructive pulmonary disease, which is characterized by emphysema. We examined the potential therapeutic effect of Wharton's Jelly-derived mesenchymal stem cells (WJMSCs), following pretreatment with pioglitazone, in lung regeneration mouse emphysema models. Methods: We used two mouse emphysema models, an elastase-induced model and a cigarette smoke-induced model. We intravenously injected WJMSCs ($1{\times}10^4/mouse$) to mice, pretreated or not, with pioglitazone for 7 days. We measured the emphysema severity by mean linear intercepts (MLI) analysis using lung histology. Results: Pioglitazone pretreated WJMSCs (pioWJMSCs) were associated with greater lung regeneration than non-augmented WJMSCs in the two mouse emphysema models. In the elastase-induced emphysema model, the MLIs were $59.02{\pm}2.42{\mu}m$ (n=6), $72.80{\pm}2.87{\mu}m$ (n=6), for pioWJMSCs injected mice, and non-augmented WJMSCs injected mice, respectively (p<0.01). Both pioWJMSCs and non-augmented WJMSCs showed regenerative effects in the cigarette smoke emphysema model (MLIs were $41.25{\pm}0.98$ [n=6] for WJMSCs and $38.97{\pm}0.61{\mu}m$ [n=6] for pioWJMSCs) compared to smoking control mice ($51.65{\pm}1.36{\mu}m$, n=6). The mean improvement of MLI appeared numerically better in pioWJMSCs than in non-augmented WJMSCs injected mice, but the difference did not reach the level of statistical significance (p=0.071). Conclusion: PioWJMSCs may produce greater lung regeneration, compared to non-augmented WJMSCs, in a mouse emphysema model.
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( Jin-soo Park ),( Hyun Kuk Kim ),( Eun-young Kang ),( Ryeonjin Cho ),( Yeon-mok Oh ) 대한결핵 및 호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.2
Background: A recent study reported that mesenchymal stem cells possess potential cellular therapeutic properties for treating patients with chronic obstructive pulmonary disease, which is characterized by emphysema. We examined the potential therapeutic effect of Wharton's Jelly-derived mesenchymal stem cells (WJMSCs), following pretreatment with pioglitazone, in lung regeneration mouse emphysema models. Methods: We used two mouse emphysema models, an elastase-induced model and a cigarette smoke-induced model. We intravenously injected WJMSCs (1.104/mouse) to mice, pretreated or not, with pioglitazone for 7 days. We measured the emphysema severity by mean linear intercepts (MLI) analysis using lung histology. Results: Pioglitazone pretreated WJMSCs (pioWJMSCs) were associated with greater lung regeneration than nonaugmented WJMSCs in the two mouse emphysema models. In the elastase-induced emphysema model, the MLIs were 59.02±2.42 μm (n=6), 72.80±2.87 μm (n=6), for pioWJMSCs injected mice, and non-augmented WJMSCs injected mice, respectively (p<0.01). Both pioWJMSCs and non-augmented WJMSCs showed regenerative effects in the cigarette smoke emphysema model (MLIs were 41.25±0.98 [n=6] for WJMSCs and38.97±0.61 μm [n=6] for pioWJMSCs) compared to smoking control mice (51.65±1.36 μm, n=6). The mean improvement of MLI appeared numerically better in pioWJMSCs than in non-augmented WJMSCs injected mice, but the difference did not reach the level of statistical significance (p=0.071). Conclusion: PioWJMSCs may produce greater lung regeneration, compared to non-augmented WJMSCs, in a mouse emphysema model.
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