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Magdalena Hofman-Bieniek,Robert Pietrzak,Katarzyna Jasiewicz 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.2
Preparation of polymeric membranes based on polyethersulfone (PES) modified by adding different amountsof a pore-forming agent (PVP) is presented, and potential application of the membranes obtained for removal of phenolfrom the liquid phase is examined. The addition of various amounts of PVP has been shown to bring about changesin the content of the surface oxygen groups, but has no significant effect on the chemical character of the groups andacidic groups dominate. Filtration by phenol solution leads to significant changes in the total content of surface oxides;however, the acidic groups remain dominant. Membranes characterized by higher porosity exhibited more stable andhigher rejection ratio for phenol removal. Although all the membranes were characterized by similar rejection ratiosfor phenol removal, the cake resistance (Rc) and pore resistance (Rp) values were found to depend significantly onthe structure and porosity of the membrane applied for filtration.
Marcin R. Lener,Aniruddh Kashyap,Wojciech Kluzniak,Cezary Cybulski,Agnieszka Soluch,Sandra Pietrzak,Tomasz Huzarski,Jacek Gronwald,Jan Lubinski 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2
Purpose Familial pancreatic cancer describes families with at least two first-degree relatives with pancreatic cancer that do not fulfil the criteria of other inherited tumor syndromes with increased risks of pancreatic cancer. Although much has been learned regarding the aggregation of pancreatic cancer in some families, the genetic basis for this familial aggregation is poorly understood. This study evaluated the prevalence of 10 Polish founder mutations in four genes among individuals from families with diagnosed familial pancreatic cancer syndrome and assessed their possible association with the familial pancreatic cancer (FPC) risk in Poland. Materials and Methods In this study, 400 FPC individuals and 4,000 control subjects were genotyped for founder mutations in BRCA1 (5382insC, 4153delA, C61G), CHEK2 (1100delC, IVS2+1G>A, del5395, I157T), NBS1 (657del5), and PALB2 (509_510delGA, 172_175delTTGT) genes. Results A statistically significant association was observed between the 172_175delTTGT mutation of the PALB2 gene and an increased risk of FPC syndrome (odds ratio [OR], 10.05; p=0.048). In addition, an increased risk of cancer was observed in the FPC family members with a BRCA1 mutation (OR, 6.72; p=0.006). Novel associations were found between the FPC family members with cancer and CHEK2mutations (OR, 2.26; p=0.008) with a noticeable contribution of the missense variant, I157T of CHEK2 (OR, 2.17; p=0.026). Conclusion The founder mutations in the genes, BRCA1, PALB2, and CHEK2, cause a small percentage of familial pancreatic cancer syndrome in the Polish population. Following confirmation in larger studies, these mutations can be added to the panel of genes to be tested in families with a diagnosis of FPC syndrome.