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Mohanraj Palanisamy,Jasmina Khanam 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.3
To study the influence of temperature and pHon solubility and dissolution behavior of indomethacinsolid dispersions were prepared using several classes ofhydrophilic carriers. Investigations on dissolution of indomethacinin binary system are reported earlier. Howeverthe phase solubility and dissolution behavior at differentpH and temperature left void. The present investigationincludes: phase solubility study at various pH; preparationof solid dispersion by solvent evaporation, melting andkneading method; characterization of various blends bydissolution study, and solid state studies to ensure interactionof drug with carrier. The binding between drug andcarriers (PVP K30, bCD and PEG) was explained bythermodynamic parameters as calculated from phase solubilitystudy. Indomethacin in association with PVP K30showed very high apparent binding constant (Ka) andGibb’s free energy change (DG) in comparison to otherblends. The ternary system (drug:bCD:PVP K30, 1:5:1)showed better dissolution of about 80.97 and 99 % at pH7.2 after 5 and 30 min respectively. At higher proportion ofcarrier (1:9) in binary solid dispersion of drug and PVPK30, drug dissolution was 96.23 and 97.85 % after 5 and30 min respectively. This raised solubility of indomethacinwould be helpful in designing a dosage form.