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Hiroshi Matsuno,Natsumi Mitou,Shin-Ichi T. Inouye 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
Mammalian circadian clock is composed of two feedback loops, a Per-Cry and Clock-Bmal1-Rev-erb loops, which are interlocked each other. This paper examines the effect of the interlocked loops from an aspect of robustness by means of simulations with hybrid functional Petri net technique, showing that Ror gene plays an important role for keeping robust oscillation in the interlocked loops of mammalian circadian clock.