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Seismic assessment and finite element modelling of glazed curtain walls
Nicola Caterino,Marta Del Zoppo,Giuseppe Maddaloni,Antonio Bonati,Giovanni Cavanna,Antonio Occhiuzzi 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.61 No.1
Glazed curtain walls are façade systems frequently chosen in modern architecture for mid and high-rise buildings. From recent earthquakes surveys it is observed the large occurrence of non-structural components failure, such as storefronts and curtain walls, which causes sensitive economic losses and represents an hazard for occupants and pedestrians safety. In the present study, the behavior of curtain wall stick systems under seismic actions has been investigated through experimental in-plane racking tests conducted at the laboratory of the Construction Technologies Institute (ITC) of the Italian National Research Council (CNR) on two full-scale aluminium/glass curtain wall test units. A finite element model has been calibrated according to experimental results in order to simulate the behavior of such components under seismic excitation. The numerical model investigates the influence of the interaction between glass panels and aluminium frame, the gasket friction and the stiffness degradation of aluminium-to-glass connections due to the high deformation level on the curtain walls behavior. This study aims to give a practical support to researchers and/or professionals who intend to numerically predict the lateral behavior of similar façade systems, so as to avoid or reduce the need of performing expensive experimental tests.
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Regulatory T-cell vaccination independent of auto-antigen
David W Pascual,Xinghong Yang,Kathryn Holderness,전상무,Massimo Maddaloni,Irina Kochetkova 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-
To date, efforts to treat autoimmune diseases have primarily focused on the disease symptoms rather than on the cause of the disease. In large part, this is attributed to not knowing the responsible auto-antigens (auto-Ags) for driving the self-reactivity coupled with the poor success of treating autoimmune diseases using oral tolerance methods. Nonetheless, if tolerogenic approaches or methods that stimulate regulatory T (Treg) cells can be devised, these could subdue autoimmune diseases. To forward such efforts, our approach with colonization factor antigen I (CFA/I) fimbriae is to establish bystander immunity to ultimately drive the development of auto-Ag-specific Treg cells. Using an attenuated Salmonella vaccine expressing CFA/I fimbriae, fimbriae-specific Treg cells were induced without compromising the vaccine’s capacity to protect against travelers’diarrhea or salmonellosis. By adapting the vaccine’s anti-inflammatory properties, it was found that it could also dampen experimental inflammatory diseases resembling multiple sclerosis (MS) and rheumatoid arthritis. Because of this bystandereffect, disease-specific Treg cells are eventually induced to resolve disease. Interestingly, this same vaccine could elicit the required Treg cell subset for each disease. For MS-like disease, conventional CD25þ Treg cells are stimulated, but for arthritisCD39þ Treg cells are induced instead. This review article will examine the potential of treating autoimmune diseases without having previous knowledge of the auto-Ag using an innocuous antigen to stimulate Treg cells via the production of transforming growth factor-b and interleukin-10.
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