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Huang, Yue-Han,Chen, Zhen-Kun,Huang, Ka-Te,Li, Peng,He, Bin,Guo, Xu,Zhong, Jun-Qiao,Zhang, Qi-Yu,Shi, Hong-Qi,Song, Qi-Tong,Yu, Zheng-Ping,Shan, Yun-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Aim: To study any correlation of LKB1 expression with prognosis in hepatocellular carcinoma (HCC) cases. Methods: A total of 70 HCC patients and 20 primary intrahepatic stone patients in the first affiliated hospital of Wenzhou Medical College were enrolled in this study. LKB1 expression was detected by immunohistochemistry. Patients were followed-up and prognostic factors were evaluated. Result: LKB1 expression was decreased in the HCC samples. Loss of LKB1 expression in HCC was significantly related to histologic grade (P=0.010), vascular invasion (P=0.025) and TMN stage (P=0.011). Patients showing negative LKB1 expression had a significantly shorter disease-free and overall survival than those with positive expression (P = 0.001, P=0.000, respectively). Multivariate Cox regression analysis indicated that LKB1 expression level was an independent factor of survival (P = 0.033). Conclusion: HCC patients with decreased expression LKB1 have a poor prognosis. The loss of LKB1 expression is correlated with a lower survival rate.
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동영상을 활용한 심리자극이 검도 선수들의 자율신경과 기분상태 및 무산소성 파워에 미치는 영향
박영진 ( Young Jin Park ),한승훈 ( Sung Whoon Han ),김동제 ( Dong Jae Kim ),최동제 ( Dong Jae Choi ),가경환 ( Kung Hwan Ka ),김병태 ( Byung Te Kim ),김영훈 ( Young Hun Kim ) 대한무도학회 2014 대한무도학회지 Vol.16 No.3
본 연구는 검도선수를 대상으로 동영상 심리자극 유·무에 따른 자율신경 반응과 기분상태검사 그리고 최대무산소를 파워 검증을 통해 동영상 자극의 심리자극의 효과를 검증하고자 하였다. 대학 검도 선수 15명을 대상으로 유튜브(You Tube) 보디빌딩 동영상 자극 후 HRV(Heart rate variability)를 측정을 통한 자율신검사와 정서 상태 프로파일(POMS)을 이용하여 기분 상태를 설문 조사하였으며, LODE사(Denmark)의 자전거 에르고미터인 Corival을 사용 무산소성 최대 운동 검사를 실시하였다. 그 결과 동영상 자극 후 부교감신경의 비율이 유의하게 낮아졌으며, 교감신경과 부교감신경의 균형비율도 교감신경의 비율을 유의하게 높였다. 기분상태 변화는 분노, 피로, 혼란은 유의하게 낮추었으며, 활력은 유의하게 높였다. 무산소성최대운동의 평균파워를 유의하게 높였다. 이와 같은 결론을 종합하면 동영상 자극은 부교감신경의 비율을 줄임으로서 활력 높은 기분 상태를 만들고 운동능력에 도움을 주는 것으로 나타나 경기 전 심신조절법으로 사용할 가치가 높다고 할 수 있다. The objective of this study is to investigate the autonomic nerve response and condition according to presences of psychological stimulations using videos for Kendo players and to verify the effect of such stimulations through monitoring the maximum anaerobic power. A questionnaire on conditions is performed using autonomous nerve tests and profile of mood states(POMS) for 15 university student Kendo players through measuring HRV(Heart Rate Variability) after applying stimulations using bodybuilding videos presented in You Tube. Then, anaerobic maximum exercise tests for the players are implemented using Corrival which is a cycle ergometer by LODE(Denmark). In the results, the rate of parasympathetic nerves is significantly decreased after the video stimulations and the rate of sympathetic nerves is significantly increased regarding the balance between sympathetic and parasympathetic nerves. In changes of conditions, it decreases angers, fatigues, and disorders significantly and increases vitalities significantly. Also, it increases average power of the anaerobic maximum exercise. In conclusion, the video stimulations bring high vital conditions by decreasing the rate of parasympathetic nerves and help to exercise capabilities. Thus, it is valuable to apply it for controlling mentality before playing a game.
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Jun-Mo Kim,Jong-Eun Park,Inkyu Yoo,Jisoo Han,Namshin Kim,Won-Jun Lim,Eun-Seok Cho,Bonghwan Choi,Sunho Choi,Tae-Hun Kim,Marinus F. W. te Pas,Hakhyun Ka,Kyung-Tai Lee 한국동물생명공학회(구 한국동물번식학회) 2018 발생공학 국제심포지엄 및 학술대회 Vol.2018 No.06
Female fertility is a highly regulated process involving the synchronized activities of multiple tissues. The underlying genomic regulation of the tissue synchronization is poorly understood. To understand this better we investigated the transcriptomes of the porcine ovary, endometrium, and oviduct at days 0, 3, 6, 9, 12, 15, or 18 of the oestrous cycle. We analysed the transcriptome profiles of the individual tissues and focus on the bridging genes shared by two or more tissues. The three tissue-networks were connected forming a triangular shape. We identified 65 bridging genes with a high level of connectivity to all other genes in the network. The expression levels showed negative correlations between the ovary and the other two tissues, and low correlations between endometrium and oviduct. The main functional annotations involved biosynthesis of steroid hormones, cell-to-cell adhesion, and cell apoptosis, suggesting that regulation of steroid hormone synthesis and tissue viability are major regulatory mechanisms.
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