http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jae-Whie (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
수부 구축성 화상반흔 환자에서 술후 관절운동범위의 개선에 관한 임상적 고찰
오재욱,강양주,정용휘 大韓成形外科 學會 1988 Archives of Plastic Surgery Vol.15 No.1
Burns of the hand are common in patients with thermal injury. But, because the treatment of burn is usually directed toward the life saving and due to the shortage of the knowledge about the postburn deformities, many patients with hand burn are found after development of severe functional impairment, In department of plastic surgery of Inje College, Baik Hospital, 59 cases of burn scar contractured hands were treated with free skin graft and aggressive physiotherapy from January of 1984 to December of 1986. The results are follow; 1) Among the 59 cases of burn contracted hands, 48 cases (81%) were excellent in results. 2) The other 11 cases of fair or poor end results were mainly due to the third degree burn and inadequate splinting after split thickness skin grafting. 3) Age of the patient had close relation to the postoperative functional recovery, the younger the better. 4) The postoperative end results in contracture after electric or flame burn were worse than in contracture after the others. 5) The results of full thickness skin graft were better than that of split thickness skin graft. 6) The time duration from burn injury to skin grafting has an important effect on postoperative end results, the longer the worse. 7) The degree of preoperative limitation of motion has close relationship with postoperative end results, the severer limitation of motion, the worse end results.
-
윤홍주,오재욱,정용휘 大韓成形外科學會 1986 Archives of Plastic Surgery Vol.13 No.1
It was not until the presentation by Illouz and Fournier at the ASPRS annual meeting in Hawaii in October 1982, that many plastic surgeons began to consider suction lipectomy as a real possibility. The idea of subcutaneous fat resection has changed by the new tools over the years. However, purchasing the foreign professional equipment accompanies with much economical burden and inhibits the development of domestic devices. From this point of view, we examined the domestic machinery on the adequacy of utilizing in suction lipectomy and operated one case without a complication. The advantages of utilizing the domestic machinery as compared with the foreign professional equipment are (1) The least economical burden and (2) A sufficient pressure for operation. On the other hand, the disadvantages of utilizing the domestic machinery as compared with the foreign professional equipment are (1) Time loss to reach a sufficient pressure, that makes and operation prolonged and (2) short length of the cannula. We wish further comparison and assessment of the domestic machinery should be made on the basis of many cases operated by it.
-
Genetic alterations of the <i>KLF6</i> gene in colorectal cancers
CHO, YONG GU,CHOI, BYUNG JUN,KIM, CHANG JAE,SONG, JAE WHIE,KIM, SU YOUNG,NAM, SUK WOO,LEE, SUG HYUNG,YOO, NAM JIN,LEE, JUNG YOUNG,PARK, WON SANG Blackwell Publishing Ltd 2006 APMIS Vol.114 No.6
<P>To investigate whether the <I>KLF6</I> gene plays an important role in the development and/or progression of colorectal cancers, we searched for mutations and allelic loss of the <I>KLF6</I> gene in 123 colorectal adenocarcinomas by performing PCR-SSCP sequencing. We found five somatic missense mutations: S155N, G163S, G163D, P183L and G195S. Three of them affected the activation domain of <I>KLF6</I> and four mutations were predicted to disrupt the putative phosphorylation sites. On LOH analysis, 63 cases were heterozygous for at least one marker and 27 cases (42.9%) showed allelic loss at these markers. These data further support that the <I>KLF6</I> gene may be one of the candidate tumor suppressor genes in colorectal cancers and that genetic alteration of the <I>KLF6</I> gene might play a role in the development of colorectal carcinomas.</P>
-
현미부수체 불안정성을 동반한 위암에서 Chk1 유전자의 돌연변이
이종흔,조용구,송재휘,박조현,김수영,남석우,이석형,유남진,이정용,박원상,Lee, Jong-Heun,Cho, Young-Gu,Song, Jae-Whie,Park, Cho-Hyun,Kim, Su-Yeong,Nam, Suk-Woo,Lee, Sug-Hyung,Yoo, Nam-Jin,Lee, Jung-Young,Park, Won-Sang 대한위암학회 2005 대한위암학회지 Vol.5 No.4
목적: Chk1 kinase는 세포 내 DNA 손상에 따른 세포주기의 저지에 관여하며 G2/M checkpoint에서 중요한 역할을 한다. 연구자들은 위암에서 현미부수체 불안정성과 Chk1 유전자의 격자이동 돌연변이와의 연관성을 알아보고자 하였다. 대상 및 방법: 95예의 위암조직에서 레이저를 이용하여 정상과 암세포를 미세절제한 다음 6개의 현미부수체 표식자를 이용하여 현미부수체 불안정성을 조사하였다. 현미부수체 불안정이 있는 예에서 single strand conformational polymorphism과 염기서열 분석으로 Chk1 유전자의 격자이동 돌연변이를 조사하였다. 결과: 현미부수체 불안정성은 95예의 위암 중 19예 (20%)에서 발견되었는데 고빈도와 저빈도의 현미부수체 불안정성은 각각 13예와 6예였다. 고빈도의 현미부수체 불안정성이 있는 13예 중 2예에서 Chk1 유전자의 격자이동 돌연변이가 발견되었는데 이는 아미노산의 격자이동으로 truncated 단백을 형성하였다. 결론 : 이러한 결과는 현미부수체 불안정성은 Chk1 유전자의 격자이동 돌연변이를 유도하여 세포주기 조절 기능을 상실하게 함으로써 위암의 발생에 관여한다는 것을 의미한다. Purpose: The protein kinase Chk1 is required for cell cycle arrest in response to DNA damage and is shown to play an important role in the G2/M checkpoint. The aim of this study was to investigate the relationship between microsatellite instability and frameshift mutation of the Chk1 gene in gastric cancers. Materials and Methods: The microsatellite instability was analyzed in 95 primary gastric carcinomas by using microdissection and 6 microsatellite markers. We also peformed single strand conformational polymorphism and sequencing to detect frameshift mutation of the Chk1 gene. Results: We found positive microsatellite instability in 19 (20%) of the 95 gastric cancers, 13 high- and 6 low-frequency microsatellite instability cases. The frameshift mutation of Chk1, which resulted in a truncated Chk1 protein, was detected in two high-frequency microsatellite instability cases. Conclusion: These data suggest that the microsatellite instability may contribute to the development of gastric carcinomas through inactivation of Chk1.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
