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RISS 인기검색어
- 검색키워드
- 저자 : Gow-Chin (검색결과 3 건)
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Hsu, Chien-Chen,Hsu, Chin-Lin,Tsai, Shao-En,Fu, Timothy Yu-Chi,Yen, Gow-Chin The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.4
The effects of the water extracts of Millettia reticulata Benth (WEMRB) and its active compound (protocatechuic acid [PCA]) on acute hepatic injury and inflammation in $CCl_4$-induced Sprague-Dawley rats were investigated. Sprague-Dawley rats were orally treated with WEMRB or PCA for 28 consecutive days, and then the rats were given an intraperitoneal injection with $CCl_4$. Pretreatment with WEMRB or PCA significantly lowered the $CCl_4$-induced serum levels of hepatic enzyme markers (aspartate and alanine aminotransferases). Liver histopathology showed that WEMRB reduced the incidence of cytoplasmic vacuolization and necrosis induced by $CCl_4$ in rats. Pretreatment with WEMRB also showed anti-inflammation on the expression of cyclooxygenase-2, inducible nitric oxide synthase, and myeloperoxidase, as well as nitrite and nitrate levels in the $CCl_4$-induced Sprague-Dawley rats. The results suggest that oral administration of WEMRB decreases the hepatotoxic effects by increasing glutathione-dependent antioxidant enzyme activity, thereby reducing oxidative stress and inflammation in $CCl_4$-induced Sprague-Dawley rats.
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Chien-Chen Hsu,Chin-Lin Hsu,Shao-En Tsai,Timothy Yu-Chi Fu,Gow-Chin Yen 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.4
The effects of the water extracts of Millettia reticulata Benth (WEMRB) and its active compound (protocatechuic acid [PCA]) on acute hepatic injury and inflammation in CCl4-induced Sprague-Dawley rats were investigated. Sprague-Dawley rats were orally treated with WEMRB or PCA for 28 consecutive days, and then the rats were given an intraperitoneal injection with CCl4. Pretreatment with WEMRB or PCA significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (aspartate and alanine aminotransferases). Liver histopathology showed that WEMRB reduced the incidence of cytoplasmic vacuolization and necrosis induced by CCl4 in rats. Pretreatment with WEMRB also showed anti-inflammation on the expression of cyclooxygenase-2, inducible nitric oxide synthase, and myeloperoxidase, as well as nitrite and nitrate levels in the CCl4-induced Sprague-Dawley rats. The results suggest that oral administration of WEMRB decreases the hepatotoxic effects by increasing glutathione-dependent antioxidant enzyme activity, thereby reducing oxidative stress and inflammation in CCl4-induced Sprague-Dawley rats.
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FEM ANALYSIS AND EXPERIMENT VALIDATION ON MULTI-PASS FORGING OF TORX ROUND FLANGE BOLT
Shih-Hsien Lin,Dyi-Cheng Chen,Un-Chin Chai,Gow-Yi Tzou 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.5
This study aims at exploring the multi-pass forging of Torx Round Flange Bolt (automotive fastener) to simulate each pass forging process using FEM simulation. The software is used to carry out the simulation analysis. Constant shear friction is always assumed at the interface between die and workpiece to explore the effective stress, the effective strain, the velocity filed, and the forging force for each pass. Through the pass schedule plan and design based on FEM analysis, the four-pass forging process is designed to form the Torx Round Flange Bolt compared the five-pass forging. It is noted that the total forging force is 1204kN, so the 200 tons machinery in the factory can be chosen to manufacture this automotive fastener. The die stress analysis for each pass has been explored to realize whether the dies are damaged or not. The forming feasibility of Torx Round Flange Bolt can be performed by FEM simulation. All dies designs and forming results can be proposed to the dies manufacture so as to perform the realistic experiments. Comparisons between FEM and experiment for final product dimensions can be carried out. The maximum dimension error is just around 3.32% to show a good agreement with the experiment. The research results can provide to the industries as the references of establishment of multi-pass forging technology.
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