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Celecoxib 유도체인 PCX-계열 화합물의 항염증 및 혈관신생 억제 작용
소지현,안은경,전혜진,임은주,박은희 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-
This study aimed to evaluate the pharmacological efficacies of PCX-series compounds, which were synthesized as prodrugs of celecoxib, a COX-2 selective inhibitor. Celecoxib, PCX-1, PCX-2, PCX-3, PCX-7, PCX-15 and PCX-16 provide potent anti-angiogenic activity in chorioallantoic membrane (CAM) assay. In addition, celecoxib, PCX-2, and PCX-16 showed anti-angiogenic activity in a dose-dependent manner. PCX-2 inhibited swelling in the carrageenan-induced rat paw edema test 24 hours after the administration. In the acetic acid-induced writhing test, PCX-7 and PCX-15 were verified to provide more potent analgesic effect than celecoxib 12 hours after the administration, and PCX-2 showed potent analgesic effect 24 hours after the administration. In the carrageenan-induced rat air pouch model, PCX-2 significantly decreased exudate volume, number of leukocyte and NO level. In the ulcerogenic activity test, PCX-2, PCX-7, PCX-15, and PCX-16 showed significantly less ulcer formation than indomethacin. Especially, PCX-7 showed the highest safety in the GI safety test. These findings provide novel pharmacological knowledge on pharmacological actions of celecoxib and its PCX-series compouds.
백종현,소창배,이은영,이지숙,신은경,박은호,서정아,양재홍,송준영,박선자,박요한,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2
Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome, typically characterized by multiple colorectal adenomas and increased incidence of colorectal carcinomas if it is not treated. Moreover, a variety of extracolonic manifestation are seen. The prevalence of thyroid tumors developing in patients with FAP is about 1∼2%. Generally, papillary thyroid cancer indicates low mortality but ,however, as people get older, the cancer becomes more aggressive. So, the operation is required. Recently we experienced a case of FAP, presenting with papillary thyroid carcinoma, and reported with a brief review of literatures.
송은지 남서울대학교 2007 남서울대학교 논문집 Vol.13 No.3
That is necessary to constitute the circuit withhigh quality for hesurface of silicon wafer, which comes tobe base to make the direct circuitof the semiconductor, Flatness, therefore, is the most important factor toguarantee the wafer with high quality. The process of polishing is one ofthe most crucial production line among 10 processing stagesto changethe rough surface into the flatness with best quality. Currently at thisprocess, it is general for an engineerin charge to observe, judge andcontrol the model of wafer from the monitor of measuring equipmentwith his/her own eyesto enhance the degree of flatness. This, however,is quite atroublesome job for someone has to check every process byone's physical experience.
A Study on the Exact Confidence Bounds for All Contrasts of Three or More Regression Lines
지은숙 광운대학교 기초과학연구소 2001 기초과학연구소논문집 Vol.30 No.-
It is desired to compare k≥3 treatments. Under the assumption of iid normal errors, it is well known that the Scheffe's method produces exact simultaneous confidence bounds for all contrasts of the treatment means. Furthermore, it is known that the Scheffe's method is conservative when one desires confidence bounds than the Scheffe's method for specific subsets of contrasts of means. In this article, multiple comparisons of the k treatments are done not in terms of their means, but rather in terms of a parametric function. The parametric function of interest is the simple linear regression model, E(Y│x). It is desired to find simultaneous confidence bounds for all contrasts of the k simple linear regression models. Although the Scheffe's method can be used to find such bounds, this is extremely conservative.
송은지 남서울대학교 2009 남서울대학교 논문집 Vol.15 No.2
In this paper we search the problems in adapt to information-oriented societies for a deaf person and handicapped women. We propose the solutions of this problems for adapt themselves to information-oriented societies. Key Words: Information-oriented societies, A deaf person, Handicapped women
김지은,박형진,송근호 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1
A 11-year-old castrated mongrel dog with the hypoadrenocorticism was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Hypoadrenocorticism was diagnosed by the clinical signs, the physical examination, laboratory examinations(complete blood count, serum chemistry), ACTH stimulation test and radiography. Clinical signs were improved after fludrocortisone treatment on the basis of ACTH stiluation test.
사회인지론에 근거한 낮병원 정신질환 입원환자 대상비만 예방 및 관리를 위한 영양교육 효과평가
한민지,이지연,이해연,한은경,최경순,김희선 순천향대학교 기초과학연구소 2021 순천향자연과학연구 논문집 Vol.27 No.1.2
Mental illness such as schizophrenia, bipolar disorder and depression have shown high prevalence of obesity. According to the previous studies, nutrition education has therapeutic effects on patients, however mentally ill patients rarely have opportunities of long term nutrition education. In this study, nutrition education based on the social cognitive theory was conducted. Patients with mental illness received education program once a month during 18 months in a day hospital. Fifteen patients were included and divided into two groups according to the attendance rate. Results showed that the group attended the education more than 10 times showed weight loss, while the group less than 10 times showed weight gain. Five long-term hospitalized patients gained weight during one year prior to the nutrition education, but showed weight loss during one year with the nutrition education. Regardless of the number of attendance, the group of BMI≥30kg/m2 showed weight loss. Although this study has several limitations and did not obtain a statistically significant results, it confirmed the necessity of providing clinical nutrition services including nutrition education for mentally ill patients.
송은지 남서울대학교 2010 남서울대학교 논문집 Vol.16 No.1-1
In this paper we research the effective web site system for the Disabled that service the more correct and faster information and that is more convenient for them. We proposed the web site system have some merits. The system was built with design that makes brighten mind of the disabled and service the information of employment for the disabled to not only the employee to but also the employer. Disabled people are another part of the population that benefit from using speech recognition programs. So we built a simple speech recognition in this system for the disabled. Key Words: Disabled , Web site, Speech- recognition
송은지 남서울대학교 2012 남서울대학교 논문집 Vol.18 No.2
Recently big data(SNS, blog etc) can be collected and monitored by buzz system. In this paper , we investigate and analysis big data about customer satisfaction feedback collected by buzz system. Key Words: Big Data, SNS, Buzz System , CRM(Customer Relationship Management), Customer Satisfaction Feedback