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Prasad G. Jamkhande,Balaji R. Ajgunde,Dhanraj R. Jadge 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.3
Annona cherimola Mill., commonly known as Custard apple has recently gained attention of researchers because of copious anticancer bioactive chemicals and nutrients. Plants of the Annonaceae family have a long history of medicinal use in the treatment of several disease conditions such as epilepsy, cardiac diseases, pathogenic infections, hemorrhage, ulcer, cancer, liver disorders and other ailments. Annona cherimola Mill. (Custard apple) is widely used in the traditional and folkloric systems of medicine. It contains numerous bioactive chemicals like annonaceous acetogenins, annocherine A, cherianoine, annocherine B, cherimoline, annomolin, romucosine H, anonaine etc. The fruit of Annona cherimola Mill. is nutritionally important as it contains high amount of carbohydrates and is a rich source of diverse vitamins such as vitamin C, vitamin B6, thiamine, riboflavin and folate. Several phytopharmacological studies have proved and explored medicinal properties of Annona cherimola Mill. Annonaceous acetogenins isolated from the seeds were found to posses potent cytotoxicity against different cancer cell lines. The crude extracts as well as isolated compounds from different plant parts exhibited pharmacological activities such as antidiabetic, antimicrobial, antidepressant, anxiolytic, antiviral, antitumor and cytoprotective. The present review focuses in detail the plant profile, nutritional and traditional uses, phytochemistry, and pharmacological properties of different parts of Annona cherimola Mill. plant.
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Prasad Govindrao Jamkhande,Mahavir H. Ghante,Sonal Ramrao Barde,Balaji R. Ajgunde 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.4
Indian cherry (Cordia dichotoma Forst.) is a medicinally important plant widely consumed as an indigenous remedy for several ailments in the India. Although it is widely used plant by the population, there are no studies on root proving these medicinal claims. The present study was designed to investigate antimicrobial, antimycobacterial and antioxidant activities of Cordia dichotoma Forst. roots and in silico biological activities prediction using PASS. Methanolic extract was prepared and further fractions were obtained by liquid–liquid partitioning. Agar well difusion assay and disc difusion method were selected for antimicrobial activity. Antimycobacterial activity was estimated against Mycobacterium tuberculosis. For antioxidant activity, DPPH and hydrogen peroxide (H2O2) radical scavenging assay were employed. All the tested samples exhibited diverse pattern of sensitivity for tested strains. The value of MIC, MMC and MIC index showed that P. vulgaris and K. pneumonia were the most sensitive for ME and CF, whereas A. fumigates and V. myditis were sensitive to CF and AF. Microorganism susceptible index was 100 for P. vulgaris and K. pneumonia bacteria, and A. fumigates and V. myditis fungi. CF exhibited best activity against M. tuberculosis with lowest MIC of 30 mg/ml and highest activity index of 0.85. Dose dependent antioxidant activity was observed in both the assay. This data provides evidence that Cordia dichotoma Forst. roots have potent antibacterial, antimycobacterial, antioxidant, and moderate antifungal activity and a potential cure for infectious diseases like tuberculosis.
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