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원성수(Sung-Soo Won) 한국정책분석평가학회 2006 政策分析評價學會報 Vol.16 No.4
The purpose of this case study is to offer informations on citizen recognition and desire for sustainable development in the historic city of Gongju. To complete the purpose of study this paper utilizes literature review in depth for the conceptualization of sustainable development and direct survey for data collection. As results, this paper finds that citizens of Gonju city exceedingly want sustainable development based on historic and cultural sightseeing in strongly relation to economic development. However, most of citizens are quite unsatisfying the current social conditions of economy, safety, cultural facilities, health, education, etc. and the quality of life. These negative factors directly effect to population decrease. Thus, to protect population decrease and to increase the degrees of citizen satisfaction local government should more try to achieve sustainable development through the broad participation of local governance.
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권경득(Kwon. Kyung Duk),김용철(Kim. Yong Chul),원성수(Won. Sung Soo),안혁근(Ahn. Hyug Keun) 한국지역개발학회 2004 韓國地域開發學會誌 Vol.16 No.3
In the process of new urban development, from the literature, ìt ìs clear that citizen participation is not an avoidable assignment any more because it already becomes one of the most important factors for the success of urban development. Under the circumstance, the purpose of thìs paper is to provide some normative altematives through lìterature review which promote effective and active citizen particìpation in the processes of new urban development. In this study, authors fìnd that citizens ’ opinions that must be reflected ìn the development process ìs more ìmportant to justify the development’s democracy and objectìvity than any other factors. Thus, to promote the justìfìcatìon, tools for cìtizen partìcipation should be systematìzed ìn the process of policy making. In additìon, the citizens' awareness of partìcìpatìon ìn the polìcy making processes should be changed actìvely by revealing theìr opinions. In sum, the combìnation between citizens' conscìousness and publìc officìals ’ democratìc attitude would maxìmìze the effect of citìzen partìcìpatìon.
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간염바이러스 X단백질 유전자를 핵산전달감염시킨 간암세포주에서 17-DMAG의 항종양효과 상승 효과
이철승 ( Chul-seung Lee ),김옥희 ( Ok-hee Kim ),홍하은 ( Ha-eun Hong ),전상진 ( Sang-jin Jeon ),원성수 ( Seong-soo Won ),김세준 ( Say-june Kim ) 대한간암학회 2017 대한간암학회지 Vol.17 No.2
Background/Aims: Hepatitis B viral protein X (HBx) is implicated in the pathogenesis of hepatocellular carcinoma (HCC) as well as the elevation of heat shock proteins (HSPs) after hepatitis B virus (HBV) infection. We thus investigated the anticancer effects of an HSP90 inhibitor 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in HBx- transfected hepatocellular carcinoma cells. Methods: pcDNA-HBx was made by inserting the HBx gene derived from the HBV-infected patient into pcDNA3.1 using the restriction enzymes (XbaI/HindIII). HBx-expressing HepG2 cells were then generated by transfecting HepG2 cells with pcDNA containing HBx gene. To compare the anticancer effects of 17-DMAG between pcDNA-HBx transfected HepG2 cells and the control cells (pcDNA-transfected HepG2 cells), we performed various molecular studies, including Ez-cytox proliferation assay, Western blot analysis, and flow cytometry. Results: 17-DMAG inhibited the proliferation of pcDNA-HBx transfected HepG2 cells better than control cells (P<0.05). After treating with a various concentration of 17-DMAG (50-1,000 nM), pcDNA-HBx transfected HepG2 cells exhibited higher expression of pro-apoptotic proteins (c-caspase-3, c-caspase-8, and c-caspase-9) than did control cells (P<0.05). pcDNA-HBx transfected HepG2 cells showed higher activities of caspase-3, caspase-8, and caspase-9 than did control cells (P<0.05). Finally, we found that the expression of pro-apoptotic proteins (PARP and c-caspase-3) was considerably decreased by the use of a caspase inhibitor suggesting that 17-DMAG induces the cell death of HepG2 cells caspase-dependently. Conclusions: Our study strongly suggests that 17-DMAG has antiviral effects against HBV as well as anticancer effects against HepG2 cells. Thus, the application of 17-DMAG appears to be particularly advantageous to the HCC patients related with HBV infection. (J Liver Cancer 2017;17:126-135)
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도시의 인구규모와 행정업무의 생산성 평가연구 : 미국의 사례
원성수 한국지역개발학회 1999 韓國地域開發學會誌 Vol.11 No.2
The public sector at the local level in the United States, has been experiencing serious fiscal difficulty since the early 1980s. As a result, public sector managers have had growing interest in productivity improvements to counter fiscal stress. However, few studies have been made about cross-jurisdictional productivity assessment for public sector due to the difficulty of its measurement. Thus, through the empirical study on the sizes of city population and administrative productivity, this study is intended to help local managers learn and use the concept of productivity improvement for the efficient and effective management of local government. In relation to the sizes of city population, this study expects that there would be somewhat significant mean differences of administrative productivity among different city sizes. That is, the planning-related function is more productive in smaller sized cities than in larger cities. And the result of the study supports the hypothesis.
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