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- 저자 : 한충섭 ( Chung Sub Han ) (검색결과 2 건)
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한상미 ( Sang Mi Han ),한충섭 ( Chung Sub Han ) 한국미용학회 2012 한국미용학회지 Vol.18 No.2
Propionibacterium acnes is a key therapeutic target in acne. We investigated whether the purified bee venom (PBV, Apis mellifera L.) is a potential candidate for anti-acne cosmetics. To determine whether the PBV kills P. acnes, we tested the activity of PBV against P. acnes using the CFU assay and transmission electron microscopic observation. PBV exhibited against antimicrobial activity in a concentration dependent manner, reducing the number of P acnes CFU by approximately 4 logs (to less than 5% maximum growth) at a concentration of 10 ng/mL. TEM observation of P. acnes treated with bacteriocin revealed cell lysis, indicating the cell membrane appears to be the primary site of action. Clinical tests were recruited with 12 subjects who were suffering from acne were selected and evaluate acne for two weeks. Based on the korean type acne severity scoring system were measured 2 times; before the test and two weeks after the test. There was a significant improvement in acne skin in both objective and subjective parameter(total microbial number in face) after the treatment with cosmetics containing PBV compared with control group (placebo). The results of this study showed that PBV had an anti-acne effects by reducing the microbial number in face through the antibacterial acivities. Taken all together, we concluded that the PBV would be an useful ingredient for the development of anti-acne cosmetics.
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한상미 ( Sang Mi Han ),홍인표 ( In Phyo Hong ),우순옥 ( Soon Ok Woo ),천성남 ( Sung Nam Chun ),한충섭 ( Chung Sub Han ) 한국미용학회 2015 한국미용학회지 Vol.21 No.2
In the last few decades, there has been a substantial increase in the population of aged people. Aging skin is a common concern for many people theses days. The purpose of this study was to evaluate the efficacy of serum containing purified bee venom in reducing wrinkles. Bee venom serum was applied to the face after toner of 22 subjects twice a day for 12 weeks The changes of the skin wrinkles were analyzed with the visual grade of wrinkle and the image of the skin replica. Compared to before and after treatment, the visual grade of wrinkle was improved 11.83% after 12 weeks. The wrinkle squares and depths were significantly reduced after 12 weeks(p<0.05). Also, the wrinkle counts were significantly reduced after 12 weeks(p<0.5). Adverse reactions of subjects were not observed during the course of the study. These observations indicate that the treatment of purified bee venom seems to be effective in improving wrinkles and can be usefully tho the anti-aging cosmetic industry.
KCI
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