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골반종양 환자에서 수술 전 혈청 CA-125와 TPA 농도의 의의
심재호,김민관,배동한,선우재근,안금성,장경택 대한부인종양 콜포스코피학회 1997 Journal of Gynecologic Oncology Vol.8 No.2
We measured serum levels of CA-125 and Tissue polypeptide antigen(TPA) in 135 patients with pelvic tumors(129 benign pelvic tumors and 6 malignant ovarian tumors) preoperatively. Each tumor marker was measured by immunoradiometric assay. Serum CA-125 levels of 35.0U/ml, 65.0U/ml and TPA levels of 80.0U/ml, 100.0U/ml were determined as cut-off values. The results were evaluated by each tumor marker and two tumor markers coincidently. The results were as follows : 1. The mean value of serum CA-125 was 33.4U/ml in the benign pelvic tumors and 167.8U/ml in malignant ovarian tumors. The mean value of serum TPA was 24.6U/ml in the benign polvic tumors and 156.4U/ml in malignant ovarian tumors. 2. The highest value of serum CA-125 was 72.9U/ml in adenomyosis in benign pelvic tumors. The highest value of serum TPA was 38.7U/ml in adenomyosis and myoma uteeri in benign pelvic turmors, but not specific. 3. The highest value of serum CA-125 was 351U/ml in malignant ovarian tumors. The highest value of serum TPA was 502.6U/ml in malignant tumors. 4. In cut0off 35U/ml, the sensitivity of preoperative CA-125 was 100%, the specificity 75.1%, the positive value 15.8%, the negative predictive value 100%. In cut-off value 65U/ml, the sensitivity of preperative TPA was 83.3%, the specificity 86.8%, the positive predictive value 55.6%, the negative predictive value 99.2%. 5. In cut-off 80U/ml, the sensitivity of preoperative value 100%, In cut-off value 100U/ml, the sensitivity of preoperative CA-125 was 66.7%, the specificity 98.4%, the positive predictive value 66.7%, the negative predictive value 98.4%. 6. The sensitivity of preoperative CA-125 and TPA coincidently was 100%, the specificity 98.4%, the positive predictive value 75.0%, the negative predictive value 100% in cut-off level 35U/ml(CA-125) and 80U/ml(TPA). The sensitivity of preoperative CA-125 and TPA coincidently was 100%, the specificity 99.2%, the positive predictive value 85.7%, the negative predictive value 100% in cut-off level 35U/ml(CA-125) and 100U/ml(TPA). The sensitivity of preoperative CA-125 and TPA coinsidently was 100%, the specificity 90.2%, the positive predictive calue 85.7%, the negative predictive value 100% in cut-off level 65U/ml(CA-125) and 80U/ml(TPA). The sensitivity of preoperative CA-125 and TPA coincidently was 83.3%, the specificity 100%, the positive predictive value 66.7%, the negative predictive value 98.4% in cut-off level 65U/ml(CA-125) and and 100U/ml(TPA). 7. No significant correlation was observed between serum level of each tumor marker, clinical stage and pathologic diagnosis.