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- 저자 : 박언섭(Eon Sub P) (검색결과 1 건)
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송형준(Hyung Jun Song),김종원(Jong Won Kim),박준석(Jun Seok Park),김용석(Yong Seok Kim),최유신(Yoo Shin Choi),김범규(Beom Gyu Kim),차성재(Sung Jae Cha),박성준(Sung Jun Park),장인택(In Taik Chang),박성일(Sung Il Park),박언섭(Eon Sub P 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.1
Purpose: Postsurgical adhesion formation is a significant clinical problem within every surgical specialty. Several adhesion barriers have been developed in the form of solution, membrane or film in an attempt to solve these problems. The purpose of the present study is to compare the efficacy of antiadhesive agents in the prevention of postsurgical adhesion formation in a standardized rat adhesion model. Methods: We examined forty Sprague-Dawley rats, which is a cecal abrasion with partial peritonectomy model. Three treatment groups (Group Ⅰ: Film-type Surgiwrap<SUP>ⓡ</SUP>, Group Ⅱ: Solution-type Guardix-sol<SUP>ⓡ</SUP>, Group Ⅲ: Membrane-type Interceed<SUP>ⓡ</SUP>), each consists of 10 rats, and a control group of 10 rats were used by saline. Ten days after surgery, the rats were killed, and the levels of adhesion were graded. Immunohistochemical staining for microvessel density (CD34, MVD) and macrophage (ED1) were performed in adhesion tissue. Results: The peritoneum adhesion mean scores are as follows: control group: 2.2±0.78, Group Ⅰ: 1.0±1.06, Group Ⅱ: 0.9±0.99, Group Ⅲ: 0.6±0.84. All treatment groups showed significantly less peritoneum adhesion (P=0.006), while there was no significant difference in each group. The intraperitoneal organs adhesion mean scores are as follows: control group: 2.8±0.91, Group I: 2.6±1.06, Group Ⅱ: 1.4±0.84, Group Ⅲ: 1.0±0.81. Group Ⅰ had no significant difference about intraperitoneal organs adhesion with control group, but Group Ⅱ and Group Ⅲ showed less intraperitoneal organs adhesion. The mean numbers of microvessel density are as follows: control group: 42.5±4.83, Group Ⅰ: 40.8±6.53, Group Ⅱ: 30.9±6.15, Group Ⅲ: 15.60±4.37, from which there was a significant difference between Group Ⅱ and Group Ⅲ with control group (P<0.001). The mean numbers of macrophage are as follows: control group: 223.3±33.12, Group I: 211.25±10.96, Group Ⅱ: 171.60±23.96, Group Ⅲ: 147.0±12.22, from which there was a significant difference between Group Ⅱ and Group Ⅲ with control group (P<0.001). Conclusion: In our animal model, three different types of antiadhesive agents (Surgiwrap<SUP>ⓡ</SUP>, Guardix-sol<SUP>ⓡ</SUP>, Interceed<SUP>ⓡ</SUP>) were effective in adhesion prevention, but Surgiwrap<SUP>ⓡ</SUP> had less antiadhesive effect for intraperitoneal organs adhesion. Membrane-type Interceed<SUP>ⓡ</SUP> had a better effect for microvessel density (MVD) and macrophage than solution-type Guardix-sol<SUP>ⓡ</SUP>.
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